Limits...
A Porous TiAl6V4 Implant Material for Medical Application.

Deing A, Luthringer B, Laipple D, Ebel T, Willumeit R - Int J Biomater (2014)

Bottom Line: These tests revealed an increasing Young's modulus with decreasing porosity; that is, "Large" and "Mix" exhibit mechanical properties closer to bone than to bulk material.By applying X-ray tomography (3D volume) and optical metallographic methods (2D volume and dimensions) the pores were dissected.The pore analysis of the "Mix" and "Large" samples showed pore volumes between 29% and 34%, respectively, with pore diameters ranging up to 175 μm and even above 200 μm for "Large." Material cytotoxicity on bone cell lines (SaOs-2 and MG-63) and primary cells (human bone-derived cells, HBDC) was studied by MTT assays and highlighted an increasing viability with higher porosity.

View Article: PubMed Central - PubMed

Affiliation: Institute of Materials Research, Helmholtz-Zentrum Geesthacht, Max-Planck-Straße 1, 21502 Geesthacht, Germany.

ABSTRACT
Increased durability of permanent TiAl6V4 implants still remains a requirement for the patient's well-being. One way to achieve a better bone-material connection is to enable bone "ingrowth" into the implant. Therefore, a new porous TiAl6V4 material was produced via metal injection moulding (MIM). Specimens with four different porosities were produced using gas-atomised spherical TiAl6V4 with different powder particle diameters, namely, "Small" (<45 μm), "Medium" (45-63 μm), "Mix" (90% 125-180 μm + 10% <45 μm), and "Large" (125-180 μm). Tensile tests, compression tests, and resonant ultrasound spectroscopy (RUS) were used to analyse mechanical properties. These tests revealed an increasing Young's modulus with decreasing porosity; that is, "Large" and "Mix" exhibit mechanical properties closer to bone than to bulk material. By applying X-ray tomography (3D volume) and optical metallographic methods (2D volume and dimensions) the pores were dissected. The pore analysis of the "Mix" and "Large" samples showed pore volumes between 29% and 34%, respectively, with pore diameters ranging up to 175 μm and even above 200 μm for "Large." Material cytotoxicity on bone cell lines (SaOs-2 and MG-63) and primary cells (human bone-derived cells, HBDC) was studied by MTT assays and highlighted an increasing viability with higher porosity.

No MeSH data available.


Related in: MedlinePlus

Microtomography. 3D image reconstruction of the pore volume of the specimen “Large” after measurement with X-ray microtomography. The dark areas represent the powder spheres while the pore volume is shown in green.
© Copyright Policy - open-access
Related In: Results  -  Collection


getmorefigures.php?uid=PMC4214099&req=5

fig2: Microtomography. 3D image reconstruction of the pore volume of the specimen “Large” after measurement with X-ray microtomography. The dark areas represent the powder spheres while the pore volume is shown in green.

Mentions: The 3D pore volume of “Mix” and “Large” (Figure 2) obtained via X-ray tomography was found to be 29.2 ± 0.6% and 34.1 ± 0.5% of the complete material volume for “Mix” and “Large,” respectively. In both materials this pore volume is formed by one interconnected pore. “Large” pore volume is 5% higher compared to “Mix.”


A Porous TiAl6V4 Implant Material for Medical Application.

Deing A, Luthringer B, Laipple D, Ebel T, Willumeit R - Int J Biomater (2014)

Microtomography. 3D image reconstruction of the pore volume of the specimen “Large” after measurement with X-ray microtomography. The dark areas represent the powder spheres while the pore volume is shown in green.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4214099&req=5

fig2: Microtomography. 3D image reconstruction of the pore volume of the specimen “Large” after measurement with X-ray microtomography. The dark areas represent the powder spheres while the pore volume is shown in green.
Mentions: The 3D pore volume of “Mix” and “Large” (Figure 2) obtained via X-ray tomography was found to be 29.2 ± 0.6% and 34.1 ± 0.5% of the complete material volume for “Mix” and “Large,” respectively. In both materials this pore volume is formed by one interconnected pore. “Large” pore volume is 5% higher compared to “Mix.”

Bottom Line: These tests revealed an increasing Young's modulus with decreasing porosity; that is, "Large" and "Mix" exhibit mechanical properties closer to bone than to bulk material.By applying X-ray tomography (3D volume) and optical metallographic methods (2D volume and dimensions) the pores were dissected.The pore analysis of the "Mix" and "Large" samples showed pore volumes between 29% and 34%, respectively, with pore diameters ranging up to 175 μm and even above 200 μm for "Large." Material cytotoxicity on bone cell lines (SaOs-2 and MG-63) and primary cells (human bone-derived cells, HBDC) was studied by MTT assays and highlighted an increasing viability with higher porosity.

View Article: PubMed Central - PubMed

Affiliation: Institute of Materials Research, Helmholtz-Zentrum Geesthacht, Max-Planck-Straße 1, 21502 Geesthacht, Germany.

ABSTRACT
Increased durability of permanent TiAl6V4 implants still remains a requirement for the patient's well-being. One way to achieve a better bone-material connection is to enable bone "ingrowth" into the implant. Therefore, a new porous TiAl6V4 material was produced via metal injection moulding (MIM). Specimens with four different porosities were produced using gas-atomised spherical TiAl6V4 with different powder particle diameters, namely, "Small" (<45 μm), "Medium" (45-63 μm), "Mix" (90% 125-180 μm + 10% <45 μm), and "Large" (125-180 μm). Tensile tests, compression tests, and resonant ultrasound spectroscopy (RUS) were used to analyse mechanical properties. These tests revealed an increasing Young's modulus with decreasing porosity; that is, "Large" and "Mix" exhibit mechanical properties closer to bone than to bulk material. By applying X-ray tomography (3D volume) and optical metallographic methods (2D volume and dimensions) the pores were dissected. The pore analysis of the "Mix" and "Large" samples showed pore volumes between 29% and 34%, respectively, with pore diameters ranging up to 175 μm and even above 200 μm for "Large." Material cytotoxicity on bone cell lines (SaOs-2 and MG-63) and primary cells (human bone-derived cells, HBDC) was studied by MTT assays and highlighted an increasing viability with higher porosity.

No MeSH data available.


Related in: MedlinePlus