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A Porous TiAl6V4 Implant Material for Medical Application.

Deing A, Luthringer B, Laipple D, Ebel T, Willumeit R - Int J Biomater (2014)

Bottom Line: These tests revealed an increasing Young's modulus with decreasing porosity; that is, "Large" and "Mix" exhibit mechanical properties closer to bone than to bulk material.By applying X-ray tomography (3D volume) and optical metallographic methods (2D volume and dimensions) the pores were dissected.The pore analysis of the "Mix" and "Large" samples showed pore volumes between 29% and 34%, respectively, with pore diameters ranging up to 175 μm and even above 200 μm for "Large." Material cytotoxicity on bone cell lines (SaOs-2 and MG-63) and primary cells (human bone-derived cells, HBDC) was studied by MTT assays and highlighted an increasing viability with higher porosity.

View Article: PubMed Central - PubMed

Affiliation: Institute of Materials Research, Helmholtz-Zentrum Geesthacht, Max-Planck-Straße 1, 21502 Geesthacht, Germany.

ABSTRACT
Increased durability of permanent TiAl6V4 implants still remains a requirement for the patient's well-being. One way to achieve a better bone-material connection is to enable bone "ingrowth" into the implant. Therefore, a new porous TiAl6V4 material was produced via metal injection moulding (MIM). Specimens with four different porosities were produced using gas-atomised spherical TiAl6V4 with different powder particle diameters, namely, "Small" (<45 μm), "Medium" (45-63 μm), "Mix" (90% 125-180 μm + 10% <45 μm), and "Large" (125-180 μm). Tensile tests, compression tests, and resonant ultrasound spectroscopy (RUS) were used to analyse mechanical properties. These tests revealed an increasing Young's modulus with decreasing porosity; that is, "Large" and "Mix" exhibit mechanical properties closer to bone than to bulk material. By applying X-ray tomography (3D volume) and optical metallographic methods (2D volume and dimensions) the pores were dissected. The pore analysis of the "Mix" and "Large" samples showed pore volumes between 29% and 34%, respectively, with pore diameters ranging up to 175 μm and even above 200 μm for "Large." Material cytotoxicity on bone cell lines (SaOs-2 and MG-63) and primary cells (human bone-derived cells, HBDC) was studied by MTT assays and highlighted an increasing viability with higher porosity.

No MeSH data available.


Microtomography. 3D image reconstruction of the pore volume of the specimen “Large” after measurement with X-ray microtomography. The dark areas represent the powder spheres while the pore volume is shown in green.
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fig2: Microtomography. 3D image reconstruction of the pore volume of the specimen “Large” after measurement with X-ray microtomography. The dark areas represent the powder spheres while the pore volume is shown in green.

Mentions: The 3D pore volume of “Mix” and “Large” (Figure 2) obtained via X-ray tomography was found to be 29.2 ± 0.6% and 34.1 ± 0.5% of the complete material volume for “Mix” and “Large,” respectively. In both materials this pore volume is formed by one interconnected pore. “Large” pore volume is 5% higher compared to “Mix.”


A Porous TiAl6V4 Implant Material for Medical Application.

Deing A, Luthringer B, Laipple D, Ebel T, Willumeit R - Int J Biomater (2014)

Microtomography. 3D image reconstruction of the pore volume of the specimen “Large” after measurement with X-ray microtomography. The dark areas represent the powder spheres while the pore volume is shown in green.
© Copyright Policy - open-access
Related In: Results  -  Collection

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getmorefigures.php?uid=PMC4214099&req=5

fig2: Microtomography. 3D image reconstruction of the pore volume of the specimen “Large” after measurement with X-ray microtomography. The dark areas represent the powder spheres while the pore volume is shown in green.
Mentions: The 3D pore volume of “Mix” and “Large” (Figure 2) obtained via X-ray tomography was found to be 29.2 ± 0.6% and 34.1 ± 0.5% of the complete material volume for “Mix” and “Large,” respectively. In both materials this pore volume is formed by one interconnected pore. “Large” pore volume is 5% higher compared to “Mix.”

Bottom Line: These tests revealed an increasing Young's modulus with decreasing porosity; that is, "Large" and "Mix" exhibit mechanical properties closer to bone than to bulk material.By applying X-ray tomography (3D volume) and optical metallographic methods (2D volume and dimensions) the pores were dissected.The pore analysis of the "Mix" and "Large" samples showed pore volumes between 29% and 34%, respectively, with pore diameters ranging up to 175 μm and even above 200 μm for "Large." Material cytotoxicity on bone cell lines (SaOs-2 and MG-63) and primary cells (human bone-derived cells, HBDC) was studied by MTT assays and highlighted an increasing viability with higher porosity.

View Article: PubMed Central - PubMed

Affiliation: Institute of Materials Research, Helmholtz-Zentrum Geesthacht, Max-Planck-Straße 1, 21502 Geesthacht, Germany.

ABSTRACT
Increased durability of permanent TiAl6V4 implants still remains a requirement for the patient's well-being. One way to achieve a better bone-material connection is to enable bone "ingrowth" into the implant. Therefore, a new porous TiAl6V4 material was produced via metal injection moulding (MIM). Specimens with four different porosities were produced using gas-atomised spherical TiAl6V4 with different powder particle diameters, namely, "Small" (<45 μm), "Medium" (45-63 μm), "Mix" (90% 125-180 μm + 10% <45 μm), and "Large" (125-180 μm). Tensile tests, compression tests, and resonant ultrasound spectroscopy (RUS) were used to analyse mechanical properties. These tests revealed an increasing Young's modulus with decreasing porosity; that is, "Large" and "Mix" exhibit mechanical properties closer to bone than to bulk material. By applying X-ray tomography (3D volume) and optical metallographic methods (2D volume and dimensions) the pores were dissected. The pore analysis of the "Mix" and "Large" samples showed pore volumes between 29% and 34%, respectively, with pore diameters ranging up to 175 μm and even above 200 μm for "Large." Material cytotoxicity on bone cell lines (SaOs-2 and MG-63) and primary cells (human bone-derived cells, HBDC) was studied by MTT assays and highlighted an increasing viability with higher porosity.

No MeSH data available.