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Multiparametric monitoring of early response to antiangiogenic therapy: a sequential perfusion CT and PET/CT study in a rabbit VX2 tumor model.

Kim JI, Lee HJ, Kim YJ, Kim KG, Lee KW, Lee JH, Lee HJ, Lee WW - ScientificWorldJournal (2014)

Bottom Line: On day 14, BF and BV in the treatment group were significantly lower than in the control group.There were no significant differences in all FDG-PET-derived parameters between both groups.In the treatment group, FMR prominently decreased after therapy and was positively correlated with MVD.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology and Institute of Radiation Medicine, Seoul National University College of Medicine & Clinical Research Institute, Seoul National University Hospital, 101 Daehangno, Jongno-gu, Seoul 110-744, Republic of Korea ; Department of Radiology, Kyung Hee University Hospital at Gangdong, Kyung Hee University College of Medicine, 892 Dongnam-ro, Gangdong-gu, Seoul 134- 727, Republic of Korea.

ABSTRACT

Objectives: To perform dual analysis of tumor perfusion and glucose metabolism using perfusion CT and FDG-PET/CT for the purpose of monitoring the early response to bevacizumab therapy in rabbit VX2 tumor models and to assess added value of FDG-PET to perfusion CT.

Methods: Twenty-four VX2 carcinoma tumors implanted in bilateral back muscles of 12 rabbits were evaluated. Serial concurrent perfusion CT and FDG-PET/CT were performed before and 3, 7, and 14 days after bevacizumab therapy (treatment group) or saline infusion (control group). Perfusion CT was analyzed to calculate blood flow (BF), blood volume (BV), and permeability surface area product (PS); FDG-PET was analyzed to calculate SUVmax, SUVmean, total lesion glycolysis (TLG), entropy, and homogeneity. The flow-metabolic ratio (FMR) was also calculated and immunohistochemical analysis of microvessel density (MVD) was performed.

Results: On day 14, BF and BV in the treatment group were significantly lower than in the control group. There were no significant differences in all FDG-PET-derived parameters between both groups. In the treatment group, FMR prominently decreased after therapy and was positively correlated with MVD.

Conclusions: In VX2 tumors, FMR could provide further insight into the early antiangiogenic effect reflecting a mismatch in intratumor blood flow and metabolism.

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Related in: MedlinePlus

Averaged (a) SUVmax, (b) SUVmean, (c) TLG, (d) entropy, and (e) homogeneity before and at different time points after bevacizumab therapy. SUVmax, SUVmean, TLG, and entropy showed an increasing trend in both groups. ∗ is significant change compared to the baseline, SUV is standardized uptake value, TLG is total lesion glycolysis, and FMR is flow-metabolic ratio.
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fig3: Averaged (a) SUVmax, (b) SUVmean, (c) TLG, (d) entropy, and (e) homogeneity before and at different time points after bevacizumab therapy. SUVmax, SUVmean, TLG, and entropy showed an increasing trend in both groups. ∗ is significant change compared to the baseline, SUV is standardized uptake value, TLG is total lesion glycolysis, and FMR is flow-metabolic ratio.

Mentions: Changes in the mean values of SUVmax, SUVmean, TLG, local entropy, local homogeneity, and FMR over time with averaging of the parameters of the entire tumor in each group are shown in Figure 3 and in Table 1. All parameters obtained from FDG-PET/CT except homogeneity showed a significant increase over time in both groups (P < 0.01 ~ 0.001) (Figure 3). Particularly on day 14, a marked increase in SUVmax, SUVmean, TLG, and entropy was observed in both groups (P < 0.001). In contrast, changes in local homogeneity were minimal over time in both groups (Figure 3).


Multiparametric monitoring of early response to antiangiogenic therapy: a sequential perfusion CT and PET/CT study in a rabbit VX2 tumor model.

Kim JI, Lee HJ, Kim YJ, Kim KG, Lee KW, Lee JH, Lee HJ, Lee WW - ScientificWorldJournal (2014)

Averaged (a) SUVmax, (b) SUVmean, (c) TLG, (d) entropy, and (e) homogeneity before and at different time points after bevacizumab therapy. SUVmax, SUVmean, TLG, and entropy showed an increasing trend in both groups. ∗ is significant change compared to the baseline, SUV is standardized uptake value, TLG is total lesion glycolysis, and FMR is flow-metabolic ratio.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4213998&req=5

fig3: Averaged (a) SUVmax, (b) SUVmean, (c) TLG, (d) entropy, and (e) homogeneity before and at different time points after bevacizumab therapy. SUVmax, SUVmean, TLG, and entropy showed an increasing trend in both groups. ∗ is significant change compared to the baseline, SUV is standardized uptake value, TLG is total lesion glycolysis, and FMR is flow-metabolic ratio.
Mentions: Changes in the mean values of SUVmax, SUVmean, TLG, local entropy, local homogeneity, and FMR over time with averaging of the parameters of the entire tumor in each group are shown in Figure 3 and in Table 1. All parameters obtained from FDG-PET/CT except homogeneity showed a significant increase over time in both groups (P < 0.01 ~ 0.001) (Figure 3). Particularly on day 14, a marked increase in SUVmax, SUVmean, TLG, and entropy was observed in both groups (P < 0.001). In contrast, changes in local homogeneity were minimal over time in both groups (Figure 3).

Bottom Line: On day 14, BF and BV in the treatment group were significantly lower than in the control group.There were no significant differences in all FDG-PET-derived parameters between both groups.In the treatment group, FMR prominently decreased after therapy and was positively correlated with MVD.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology and Institute of Radiation Medicine, Seoul National University College of Medicine & Clinical Research Institute, Seoul National University Hospital, 101 Daehangno, Jongno-gu, Seoul 110-744, Republic of Korea ; Department of Radiology, Kyung Hee University Hospital at Gangdong, Kyung Hee University College of Medicine, 892 Dongnam-ro, Gangdong-gu, Seoul 134- 727, Republic of Korea.

ABSTRACT

Objectives: To perform dual analysis of tumor perfusion and glucose metabolism using perfusion CT and FDG-PET/CT for the purpose of monitoring the early response to bevacizumab therapy in rabbit VX2 tumor models and to assess added value of FDG-PET to perfusion CT.

Methods: Twenty-four VX2 carcinoma tumors implanted in bilateral back muscles of 12 rabbits were evaluated. Serial concurrent perfusion CT and FDG-PET/CT were performed before and 3, 7, and 14 days after bevacizumab therapy (treatment group) or saline infusion (control group). Perfusion CT was analyzed to calculate blood flow (BF), blood volume (BV), and permeability surface area product (PS); FDG-PET was analyzed to calculate SUVmax, SUVmean, total lesion glycolysis (TLG), entropy, and homogeneity. The flow-metabolic ratio (FMR) was also calculated and immunohistochemical analysis of microvessel density (MVD) was performed.

Results: On day 14, BF and BV in the treatment group were significantly lower than in the control group. There were no significant differences in all FDG-PET-derived parameters between both groups. In the treatment group, FMR prominently decreased after therapy and was positively correlated with MVD.

Conclusions: In VX2 tumors, FMR could provide further insight into the early antiangiogenic effect reflecting a mismatch in intratumor blood flow and metabolism.

Show MeSH
Related in: MedlinePlus