Limits...
The Tumor Necrosis Factor-α-308 and -238 Polymorphisms and Risk of Hepatocellular Carcinoma for Asian Populations: A Meta-Analysis.

Hu Q, Lou GG, Liu YC, Qian L, Lv BD - Curr Ther Res Clin Exp (2014)

Bottom Line: Overall, the frequency of the A allele was higher in patients with HCC than in the healthy controls (10.2% vs 7.5%), and the A allele and allele carrier were significantly associated with increased risk of HCC in a random effects model (A vs G: OR = 1.57; 95% CI, 1.22-2.01; P = 0.0004; AA + AG vs GG: OR = 1.62; 95% CI, 1.18-2.22; P = 0.003).Our meta-analysis proved that the TNF-α-308 G/A polymorphism is associated with increased susceptibility to HCC.However, the TNF-α-238 G/A polymorphism is not significantly associated with risk of HCC in Asian populations.

View Article: PubMed Central - PubMed

Affiliation: The Second Affiliated Hospital, Zhejiang Traditional Chinese Medical University , Hangzhou, China.

ABSTRACT

Background: Tumor necrosis factor-α (TNF-α) has been suggested to play a very important role in the development and progression of hepatocellular carcinoma (HCC). Many studies have identified the associations of TNF-α-308 and -238 polymorphisms with HCC risk, but the results remain controversial.

Aim: We conducted this meta-analysis to evaluate the associations between TNF-α-308 and -238 polymorphisms and HCC susceptibility.

Methods: PubMed, Embase, and China National Knowledge Infrastructure electronic databases were searched for all articles on associations between TNF-α-308 and -238 polymorphisms and HCC risk in Asians through September 30, 2013. Odds ratios (ORs) and their 95% CIs were calculated to assess the strength of this association.

Results: A total of 17 case-control studies were identified in our meta-analysis. For the TNF-α-308 G/A polymorphism, 14 studies containing 3154 cases and 3767 controls were included. Overall, the frequency of the A allele was higher in patients with HCC than in the healthy controls (10.2% vs 7.5%), and the A allele and allele carrier were significantly associated with increased risk of HCC in a random effects model (A vs G: OR = 1.57; 95% CI, 1.22-2.01; P = 0.0004; AA + AG vs GG: OR = 1.62; 95% CI, 1.18-2.22; P = 0.003). For the TNF-α-238 polymorphism, 10 research articles were identified. No association was found between the TNF-α-238 G/A polymorphism and risk of HCC in any genetic models (P > 0.05). The sensitivity analysis further strengthened the overall correlations.

Conclusions: Our meta-analysis proved that the TNF-α-308 G/A polymorphism is associated with increased susceptibility to HCC. However, the TNF-α-238 G/A polymorphism is not significantly associated with risk of HCC in Asian populations. Further studies with large sample sizes are needed to confirm these associations among other populations.

No MeSH data available.


Related in: MedlinePlus

Odds ratios and 95% CIs of hepatocellular carcinoma according to tumor necrosis factor-α-238 polymorphism in 10 studies using a random-effect model. AA + GA, AA, and GA genotypes of tumor necrosis factor-α-238 polymorphism and GG, GG genotype of tumor necrosis factor-α-238 polymorphism. M-H = xxxxxxxx.
© Copyright Policy - CC BY-NC-ND
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4209508&req=5

f0025: Odds ratios and 95% CIs of hepatocellular carcinoma according to tumor necrosis factor-α-238 polymorphism in 10 studies using a random-effect model. AA + GA, AA, and GA genotypes of tumor necrosis factor-α-238 polymorphism and GG, GG genotype of tumor necrosis factor-α-238 polymorphism. M-H = xxxxxxxx.

Mentions: Table II shows the OR for HCC of TNF-α-238 G/A polymorphism with the variant genotypes. The heterogeneity between studies was significant and a random-effects model was employed. As shown in Figures 4 and 5, no significant associations were found in any genotypes (A vs G: OR = 1.06; 95% CI, 0.59–1.92; P = 0.85; AA vs GG: OR = 0.40; 95% CI, 0.05–2.92; P = 0.36; AA + AG vs GG: OR = 1.13; 95% CI, 0.68–1.89; P = 0.64; AA vs AG + GG: OR = 0.39; 95% CI, 0.05–3.02; P = 0.37). This demonstrated that this polymorphism was not associated with HCC risk.


The Tumor Necrosis Factor-α-308 and -238 Polymorphisms and Risk of Hepatocellular Carcinoma for Asian Populations: A Meta-Analysis.

Hu Q, Lou GG, Liu YC, Qian L, Lv BD - Curr Ther Res Clin Exp (2014)

Odds ratios and 95% CIs of hepatocellular carcinoma according to tumor necrosis factor-α-238 polymorphism in 10 studies using a random-effect model. AA + GA, AA, and GA genotypes of tumor necrosis factor-α-238 polymorphism and GG, GG genotype of tumor necrosis factor-α-238 polymorphism. M-H = xxxxxxxx.
© Copyright Policy - CC BY-NC-ND
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4209508&req=5

f0025: Odds ratios and 95% CIs of hepatocellular carcinoma according to tumor necrosis factor-α-238 polymorphism in 10 studies using a random-effect model. AA + GA, AA, and GA genotypes of tumor necrosis factor-α-238 polymorphism and GG, GG genotype of tumor necrosis factor-α-238 polymorphism. M-H = xxxxxxxx.
Mentions: Table II shows the OR for HCC of TNF-α-238 G/A polymorphism with the variant genotypes. The heterogeneity between studies was significant and a random-effects model was employed. As shown in Figures 4 and 5, no significant associations were found in any genotypes (A vs G: OR = 1.06; 95% CI, 0.59–1.92; P = 0.85; AA vs GG: OR = 0.40; 95% CI, 0.05–2.92; P = 0.36; AA + AG vs GG: OR = 1.13; 95% CI, 0.68–1.89; P = 0.64; AA vs AG + GG: OR = 0.39; 95% CI, 0.05–3.02; P = 0.37). This demonstrated that this polymorphism was not associated with HCC risk.

Bottom Line: Overall, the frequency of the A allele was higher in patients with HCC than in the healthy controls (10.2% vs 7.5%), and the A allele and allele carrier were significantly associated with increased risk of HCC in a random effects model (A vs G: OR = 1.57; 95% CI, 1.22-2.01; P = 0.0004; AA + AG vs GG: OR = 1.62; 95% CI, 1.18-2.22; P = 0.003).Our meta-analysis proved that the TNF-α-308 G/A polymorphism is associated with increased susceptibility to HCC.However, the TNF-α-238 G/A polymorphism is not significantly associated with risk of HCC in Asian populations.

View Article: PubMed Central - PubMed

Affiliation: The Second Affiliated Hospital, Zhejiang Traditional Chinese Medical University , Hangzhou, China.

ABSTRACT

Background: Tumor necrosis factor-α (TNF-α) has been suggested to play a very important role in the development and progression of hepatocellular carcinoma (HCC). Many studies have identified the associations of TNF-α-308 and -238 polymorphisms with HCC risk, but the results remain controversial.

Aim: We conducted this meta-analysis to evaluate the associations between TNF-α-308 and -238 polymorphisms and HCC susceptibility.

Methods: PubMed, Embase, and China National Knowledge Infrastructure electronic databases were searched for all articles on associations between TNF-α-308 and -238 polymorphisms and HCC risk in Asians through September 30, 2013. Odds ratios (ORs) and their 95% CIs were calculated to assess the strength of this association.

Results: A total of 17 case-control studies were identified in our meta-analysis. For the TNF-α-308 G/A polymorphism, 14 studies containing 3154 cases and 3767 controls were included. Overall, the frequency of the A allele was higher in patients with HCC than in the healthy controls (10.2% vs 7.5%), and the A allele and allele carrier were significantly associated with increased risk of HCC in a random effects model (A vs G: OR = 1.57; 95% CI, 1.22-2.01; P = 0.0004; AA + AG vs GG: OR = 1.62; 95% CI, 1.18-2.22; P = 0.003). For the TNF-α-238 polymorphism, 10 research articles were identified. No association was found between the TNF-α-238 G/A polymorphism and risk of HCC in any genetic models (P > 0.05). The sensitivity analysis further strengthened the overall correlations.

Conclusions: Our meta-analysis proved that the TNF-α-308 G/A polymorphism is associated with increased susceptibility to HCC. However, the TNF-α-238 G/A polymorphism is not significantly associated with risk of HCC in Asian populations. Further studies with large sample sizes are needed to confirm these associations among other populations.

No MeSH data available.


Related in: MedlinePlus