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The Tumor Necrosis Factor-α-308 and -238 Polymorphisms and Risk of Hepatocellular Carcinoma for Asian Populations: A Meta-Analysis.

Hu Q, Lou GG, Liu YC, Qian L, Lv BD - Curr Ther Res Clin Exp (2014)

Bottom Line: No association was found between the TNF-α-238 G/A polymorphism and risk of HCC in any genetic models (P > 0.05).Our meta-analysis proved that the TNF-α-308 G/A polymorphism is associated with increased susceptibility to HCC.However, the TNF-α-238 G/A polymorphism is not significantly associated with risk of HCC in Asian populations.

View Article: PubMed Central - PubMed

Affiliation: The Second Affiliated Hospital, Zhejiang Traditional Chinese Medical University , Hangzhou, China.

ABSTRACT

Background: Tumor necrosis factor-α (TNF-α) has been suggested to play a very important role in the development and progression of hepatocellular carcinoma (HCC). Many studies have identified the associations of TNF-α-308 and -238 polymorphisms with HCC risk, but the results remain controversial.

Aim: We conducted this meta-analysis to evaluate the associations between TNF-α-308 and -238 polymorphisms and HCC susceptibility.

Methods: PubMed, Embase, and China National Knowledge Infrastructure electronic databases were searched for all articles on associations between TNF-α-308 and -238 polymorphisms and HCC risk in Asians through September 30, 2013. Odds ratios (ORs) and their 95% CIs were calculated to assess the strength of this association.

Results: A total of 17 case-control studies were identified in our meta-analysis. For the TNF-α-308 G/A polymorphism, 14 studies containing 3154 cases and 3767 controls were included. Overall, the frequency of the A allele was higher in patients with HCC than in the healthy controls (10.2% vs 7.5%), and the A allele and allele carrier were significantly associated with increased risk of HCC in a random effects model (A vs G: OR = 1.57; 95% CI, 1.22-2.01; P = 0.0004; AA + AG vs GG: OR = 1.62; 95% CI, 1.18-2.22; P = 0.003). For the TNF-α-238 polymorphism, 10 research articles were identified. No association was found between the TNF-α-238 G/A polymorphism and risk of HCC in any genetic models (P > 0.05). The sensitivity analysis further strengthened the overall correlations.

Conclusions: Our meta-analysis proved that the TNF-α-308 G/A polymorphism is associated with increased susceptibility to HCC. However, the TNF-α-238 G/A polymorphism is not significantly associated with risk of HCC in Asian populations. Further studies with large sample sizes are needed to confirm these associations among other populations.

No MeSH data available.


Related in: MedlinePlus

Forest plot of the association between A allele and hepatocellular carcinoma according to tumor necrosis factor-α-308 polymorphism in an Asian population. M-H = xxxxxxxx.
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f0010: Forest plot of the association between A allele and hepatocellular carcinoma according to tumor necrosis factor-α-308 polymorphism in an Asian population. M-H = xxxxxxxx.

Mentions: The main results of meta-analysis of the association between the TNF-α-308 G/A polymorphism and HCC risk are shown in Table II. Overall, the frequency of the A allele is higher in patients with HCC than in healthy controls (10.2% vs 7.5%). As shown in Figures 2 and 3, our results showed that there was a significant association between the TNF-α-308 G/A polymorphism and increased risk of HCC under allelic and dominant effects (A vs G: OR = 1.57; 95% CI, 1.22–2.01; P = 0.0004; AA + AG vs GG: OR = 1.62; 95% CI, 1.18–2.22; P = 0.003) in a random-effects model, indicating that being an A carrier may be a risk factor for developing HCC among Asians. However, under codominant effects and recessive effects, no significant associations were found (AA vs GG: OR = 1.15; 95% CI, 0.70–1.89; P = 0.57; AA vs AG + GG: OR = 1.12; 95% CI, 0.68–1.84; P = 0.65) in a fixed model.


The Tumor Necrosis Factor-α-308 and -238 Polymorphisms and Risk of Hepatocellular Carcinoma for Asian Populations: A Meta-Analysis.

Hu Q, Lou GG, Liu YC, Qian L, Lv BD - Curr Ther Res Clin Exp (2014)

Forest plot of the association between A allele and hepatocellular carcinoma according to tumor necrosis factor-α-308 polymorphism in an Asian population. M-H = xxxxxxxx.
© Copyright Policy - CC BY-NC-ND
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4209508&req=5

f0010: Forest plot of the association between A allele and hepatocellular carcinoma according to tumor necrosis factor-α-308 polymorphism in an Asian population. M-H = xxxxxxxx.
Mentions: The main results of meta-analysis of the association between the TNF-α-308 G/A polymorphism and HCC risk are shown in Table II. Overall, the frequency of the A allele is higher in patients with HCC than in healthy controls (10.2% vs 7.5%). As shown in Figures 2 and 3, our results showed that there was a significant association between the TNF-α-308 G/A polymorphism and increased risk of HCC under allelic and dominant effects (A vs G: OR = 1.57; 95% CI, 1.22–2.01; P = 0.0004; AA + AG vs GG: OR = 1.62; 95% CI, 1.18–2.22; P = 0.003) in a random-effects model, indicating that being an A carrier may be a risk factor for developing HCC among Asians. However, under codominant effects and recessive effects, no significant associations were found (AA vs GG: OR = 1.15; 95% CI, 0.70–1.89; P = 0.57; AA vs AG + GG: OR = 1.12; 95% CI, 0.68–1.84; P = 0.65) in a fixed model.

Bottom Line: No association was found between the TNF-α-238 G/A polymorphism and risk of HCC in any genetic models (P > 0.05).Our meta-analysis proved that the TNF-α-308 G/A polymorphism is associated with increased susceptibility to HCC.However, the TNF-α-238 G/A polymorphism is not significantly associated with risk of HCC in Asian populations.

View Article: PubMed Central - PubMed

Affiliation: The Second Affiliated Hospital, Zhejiang Traditional Chinese Medical University , Hangzhou, China.

ABSTRACT

Background: Tumor necrosis factor-α (TNF-α) has been suggested to play a very important role in the development and progression of hepatocellular carcinoma (HCC). Many studies have identified the associations of TNF-α-308 and -238 polymorphisms with HCC risk, but the results remain controversial.

Aim: We conducted this meta-analysis to evaluate the associations between TNF-α-308 and -238 polymorphisms and HCC susceptibility.

Methods: PubMed, Embase, and China National Knowledge Infrastructure electronic databases were searched for all articles on associations between TNF-α-308 and -238 polymorphisms and HCC risk in Asians through September 30, 2013. Odds ratios (ORs) and their 95% CIs were calculated to assess the strength of this association.

Results: A total of 17 case-control studies were identified in our meta-analysis. For the TNF-α-308 G/A polymorphism, 14 studies containing 3154 cases and 3767 controls were included. Overall, the frequency of the A allele was higher in patients with HCC than in the healthy controls (10.2% vs 7.5%), and the A allele and allele carrier were significantly associated with increased risk of HCC in a random effects model (A vs G: OR = 1.57; 95% CI, 1.22-2.01; P = 0.0004; AA + AG vs GG: OR = 1.62; 95% CI, 1.18-2.22; P = 0.003). For the TNF-α-238 polymorphism, 10 research articles were identified. No association was found between the TNF-α-238 G/A polymorphism and risk of HCC in any genetic models (P > 0.05). The sensitivity analysis further strengthened the overall correlations.

Conclusions: Our meta-analysis proved that the TNF-α-308 G/A polymorphism is associated with increased susceptibility to HCC. However, the TNF-α-238 G/A polymorphism is not significantly associated with risk of HCC in Asian populations. Further studies with large sample sizes are needed to confirm these associations among other populations.

No MeSH data available.


Related in: MedlinePlus