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A 5-year follow-up after cartilage repair in the knee using a platelet-rich plasma-immersed polymer-based implant.

Siclari A, Mascaro G, Kaps C, Boux E - Open Orthop J (2014)

Bottom Line: The KOOS showed clinically meaningful and significant (p < 0.05) improvement in all subcategories compared to baseline.Cartilage repair was complete in 20 out of 21 patients at 4-year follow-up as shown by magnetic resonance observation of cartilage repair tissue (MOCART) scoring.Covering of focal cartilage defects with the PGA-HA implant and PRP after bone marrow stimulation leads to a lasting improvement of the patients' situation.

View Article: PubMed Central - PubMed

Affiliation: Struttura Complessa di Ortopedia e Traumatologia, Ospedale degli Infermi di Biella ASLBI, Biella, Italy.

ABSTRACT
The aim of our study was to analyze the clinical outcome after repair of cartilage defects of the knee with subchondral drilling and resorbable polymer-based implants immersed with autologous platelet-rich plasma (PRP). Fifty-two patients with focal chondral defects were treated with subchondral drilling, followed by covering with a polyglycolic acid - hyaluronan (PGA-HA) implant (chondrotissue®) immersed with autologous PRP. At 5-year follow-up, patients' situation was assessed using the Knee Injury and Osteoarthritis Outcome Score (KOOS) and compared to the pre-operative situation. The KOOS showed clinically meaningful and significant (p < 0.05) improvement in all subcategories compared to baseline. Subgroup analysis showed that there were no differences in the clinical outcome regarding defect size and localization as well as degenerative condition of the knee. Cartilage repair was complete in 20 out of 21 patients at 4-year follow-up as shown by magnetic resonance observation of cartilage repair tissue (MOCART) scoring. Covering of focal cartilage defects with the PGA-HA implant and PRP after bone marrow stimulation leads to a lasting improvement of the patients' situation.

No MeSH data available.


Related in: MedlinePlus

Clinical outcome after five years as assessed by the Knee injury and Osteoarthritis Outcome Score (KOOS). The KOOS profilesprior to and 1 year, 2 years and 5 years after implantation of the PGA-HA implant are presented (n=52). The columns show the mean anderror bars define standard deviation (SD). spt, symptoms; ADL, activities of daily living; sport&recr, sports and recreation; QoL, quality oflife. Pre-operative KOOS raw data, the 1-year follow-up and the 2-year follow-up data were taken from previous reports [24, 25].
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Figure 1: Clinical outcome after five years as assessed by the Knee injury and Osteoarthritis Outcome Score (KOOS). The KOOS profilesprior to and 1 year, 2 years and 5 years after implantation of the PGA-HA implant are presented (n=52). The columns show the mean anderror bars define standard deviation (SD). spt, symptoms; ADL, activities of daily living; sport&recr, sports and recreation; QoL, quality oflife. Pre-operative KOOS raw data, the 1-year follow-up and the 2-year follow-up data were taken from previous reports [24, 25].

Mentions: Clinical scoring and analysis of KOOS values showed a clinically meaningful (ΔKOOS > 10) and significant (p< 0.001) improvement in all KOOS sub-categories at 1-year, 2-year and 5-year follow-up, compared to the pre-operative situation (Fig. 1). Pain improved from a mean of 54.1 pre-operatively to a mean of 93.5 at 5-year follow-up, symptoms from 56.3 to 91.3, activities of daily living from 68.1 to 89.5, sport&recreation from 35.5 to 74.5, and the subcategory quality of live improved from 37.2 to 76.4. The overall KOOS showed a mean of 50.3 at baseline and increased to a mean of 85.0 at 5 years follow-up, leading to an average ΔKOOS of 34.7. Differences in KOOS values between the 1-year and 2-year follow-up as well as between 1-year or 2-year and the 5-year follow-up values were less than 10 KOOS points and have been considered to be clinically not relevant.


A 5-year follow-up after cartilage repair in the knee using a platelet-rich plasma-immersed polymer-based implant.

Siclari A, Mascaro G, Kaps C, Boux E - Open Orthop J (2014)

Clinical outcome after five years as assessed by the Knee injury and Osteoarthritis Outcome Score (KOOS). The KOOS profilesprior to and 1 year, 2 years and 5 years after implantation of the PGA-HA implant are presented (n=52). The columns show the mean anderror bars define standard deviation (SD). spt, symptoms; ADL, activities of daily living; sport&recr, sports and recreation; QoL, quality oflife. Pre-operative KOOS raw data, the 1-year follow-up and the 2-year follow-up data were taken from previous reports [24, 25].
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4209503&req=5

Figure 1: Clinical outcome after five years as assessed by the Knee injury and Osteoarthritis Outcome Score (KOOS). The KOOS profilesprior to and 1 year, 2 years and 5 years after implantation of the PGA-HA implant are presented (n=52). The columns show the mean anderror bars define standard deviation (SD). spt, symptoms; ADL, activities of daily living; sport&recr, sports and recreation; QoL, quality oflife. Pre-operative KOOS raw data, the 1-year follow-up and the 2-year follow-up data were taken from previous reports [24, 25].
Mentions: Clinical scoring and analysis of KOOS values showed a clinically meaningful (ΔKOOS > 10) and significant (p< 0.001) improvement in all KOOS sub-categories at 1-year, 2-year and 5-year follow-up, compared to the pre-operative situation (Fig. 1). Pain improved from a mean of 54.1 pre-operatively to a mean of 93.5 at 5-year follow-up, symptoms from 56.3 to 91.3, activities of daily living from 68.1 to 89.5, sport&recreation from 35.5 to 74.5, and the subcategory quality of live improved from 37.2 to 76.4. The overall KOOS showed a mean of 50.3 at baseline and increased to a mean of 85.0 at 5 years follow-up, leading to an average ΔKOOS of 34.7. Differences in KOOS values between the 1-year and 2-year follow-up as well as between 1-year or 2-year and the 5-year follow-up values were less than 10 KOOS points and have been considered to be clinically not relevant.

Bottom Line: The KOOS showed clinically meaningful and significant (p < 0.05) improvement in all subcategories compared to baseline.Cartilage repair was complete in 20 out of 21 patients at 4-year follow-up as shown by magnetic resonance observation of cartilage repair tissue (MOCART) scoring.Covering of focal cartilage defects with the PGA-HA implant and PRP after bone marrow stimulation leads to a lasting improvement of the patients' situation.

View Article: PubMed Central - PubMed

Affiliation: Struttura Complessa di Ortopedia e Traumatologia, Ospedale degli Infermi di Biella ASLBI, Biella, Italy.

ABSTRACT
The aim of our study was to analyze the clinical outcome after repair of cartilage defects of the knee with subchondral drilling and resorbable polymer-based implants immersed with autologous platelet-rich plasma (PRP). Fifty-two patients with focal chondral defects were treated with subchondral drilling, followed by covering with a polyglycolic acid - hyaluronan (PGA-HA) implant (chondrotissue®) immersed with autologous PRP. At 5-year follow-up, patients' situation was assessed using the Knee Injury and Osteoarthritis Outcome Score (KOOS) and compared to the pre-operative situation. The KOOS showed clinically meaningful and significant (p < 0.05) improvement in all subcategories compared to baseline. Subgroup analysis showed that there were no differences in the clinical outcome regarding defect size and localization as well as degenerative condition of the knee. Cartilage repair was complete in 20 out of 21 patients at 4-year follow-up as shown by magnetic resonance observation of cartilage repair tissue (MOCART) scoring. Covering of focal cartilage defects with the PGA-HA implant and PRP after bone marrow stimulation leads to a lasting improvement of the patients' situation.

No MeSH data available.


Related in: MedlinePlus