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Epithelial Stem Cells of the Skin Contribute to the Histopathologic Umbrella-like Appearance in Actinic Keratosis.

Mihara M - Yonago Acta Med (2014)

Bottom Line: Although the histopathologic umbrella-like appearance of the epidermis in actinic keratosis (AK) is well known, its histopathogenesis has remained unknown.The author suggests that the penetration depth of ultraviolet B (UVB) radiation can account for such a histopathologic feature by affecting specific epidermal stem cell pools, as the stem cells in the epidermis and the bulge stem cells and sebocyte stem cells in the mid-dermis reside at different depths.

View Article: PubMed Central - PubMed

Affiliation: Mihara Dermatology Clinic, Tottori University, 1933-1 Takao, Niimi 718-0003, Japan.

ABSTRACT
Although the histopathologic umbrella-like appearance of the epidermis in actinic keratosis (AK) is well known, its histopathogenesis has remained unknown. The author suggests that the penetration depth of ultraviolet B (UVB) radiation can account for such a histopathologic feature by affecting specific epidermal stem cell pools, as the stem cells in the epidermis and the bulge stem cells and sebocyte stem cells in the mid-dermis reside at different depths.

No MeSH data available.


Related in: MedlinePlus

Umbrella-like appearance in actinic keratosis (AK). The border between acrotrichial cells(at) and dysplastic epithelial cells of actinic keratosis (ak) is sharplydefined (hematoxylin and eosin stain). Bar = 50 µm.
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fig_001: Umbrella-like appearance in actinic keratosis (AK). The border between acrotrichial cells(at) and dysplastic epithelial cells of actinic keratosis (ak) is sharplydefined (hematoxylin and eosin stain). Bar = 50 µm.

Mentions: The epithelial component of the epidermis consists of epidermal cells and appendageal cells,including acrotrichial cells and acrosyringeal cells. Pinkus and Mehregan2 proposed a theory termed epidermal symbiosis. According to the theory, the epidermal cellsand the appendageal cells maintain homeostasis by mitotic division of their own germinal cells,and they may independently act and react under pathologic conditions. Thus, AK may be considered to bea pathologic condition in which the interrelationship between the epidermal cells and the appendageal cells isdisorganised. As described previously,2 the acrotrichial cellsare essentially indistinguishable from the surrounding epidermal cells under normal conditions,while their border is sharply defined in AK (Fig. 1 ),resulting in the characteristic umbrella-like appearance.


Epithelial Stem Cells of the Skin Contribute to the Histopathologic Umbrella-like Appearance in Actinic Keratosis.

Mihara M - Yonago Acta Med (2014)

Umbrella-like appearance in actinic keratosis (AK). The border between acrotrichial cells(at) and dysplastic epithelial cells of actinic keratosis (ak) is sharplydefined (hematoxylin and eosin stain). Bar = 50 µm.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4209342&req=5

fig_001: Umbrella-like appearance in actinic keratosis (AK). The border between acrotrichial cells(at) and dysplastic epithelial cells of actinic keratosis (ak) is sharplydefined (hematoxylin and eosin stain). Bar = 50 µm.
Mentions: The epithelial component of the epidermis consists of epidermal cells and appendageal cells,including acrotrichial cells and acrosyringeal cells. Pinkus and Mehregan2 proposed a theory termed epidermal symbiosis. According to the theory, the epidermal cellsand the appendageal cells maintain homeostasis by mitotic division of their own germinal cells,and they may independently act and react under pathologic conditions. Thus, AK may be considered to bea pathologic condition in which the interrelationship between the epidermal cells and the appendageal cells isdisorganised. As described previously,2 the acrotrichial cellsare essentially indistinguishable from the surrounding epidermal cells under normal conditions,while their border is sharply defined in AK (Fig. 1 ),resulting in the characteristic umbrella-like appearance.

Bottom Line: Although the histopathologic umbrella-like appearance of the epidermis in actinic keratosis (AK) is well known, its histopathogenesis has remained unknown.The author suggests that the penetration depth of ultraviolet B (UVB) radiation can account for such a histopathologic feature by affecting specific epidermal stem cell pools, as the stem cells in the epidermis and the bulge stem cells and sebocyte stem cells in the mid-dermis reside at different depths.

View Article: PubMed Central - PubMed

Affiliation: Mihara Dermatology Clinic, Tottori University, 1933-1 Takao, Niimi 718-0003, Japan.

ABSTRACT
Although the histopathologic umbrella-like appearance of the epidermis in actinic keratosis (AK) is well known, its histopathogenesis has remained unknown. The author suggests that the penetration depth of ultraviolet B (UVB) radiation can account for such a histopathologic feature by affecting specific epidermal stem cell pools, as the stem cells in the epidermis and the bulge stem cells and sebocyte stem cells in the mid-dermis reside at different depths.

No MeSH data available.


Related in: MedlinePlus