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The expression of melanoma inhibitory activity on mast cells in child patients with cutaneous mastocytosis.

Ehara Y, Yoshida Y, Tahira M, Yamamoto O - Yonago Acta Med (2014)

Bottom Line: MIA was positive for infiltrating mast cells in all patients.Serum level of MIA was elevated in 1 patient.Although it was difficult to assess the significance of elevated serum levels of MIA in child patients, MIA was expressed on infiltrating mast cells in our study.

View Article: PubMed Central - PubMed

Affiliation: Division of Dermatology, Department of Medicine of Sensory and Motor Organs, School of Medicine, Tottori University Faculty of Medicine, Yonago 683-8504, Japan.

ABSTRACT

Background: Cutaneous mastocytosis is a disorder characterized by the proliferation of mast cells in the skin. Melanoma inhibitory activity (MIA) is a serum marker for malignant melanoma. However, it has not been known on MIA expression of cutaneous mastocytosis.

Methods: We investigated the expression of MIA in 4 child patients with cutaneous mastocytosis immunohistochemically and serum MIA level in 1 patient by enzyme-linked immunosorbent assay.

Results: Histopathological examination revealed diffuse mast cell infiltration in the dermis. MIA was positive for infiltrating mast cells in all patients. Serum level of MIA was elevated in 1 patient.

Conclusion: Although it was difficult to assess the significance of elevated serum levels of MIA in child patients, MIA was expressed on infiltrating mast cells in our study. Based on our findings, mast cell-derived MIA might be related to the formation of pigmented regions in cutaneous mastocytosis.

No MeSH data available.


Related in: MedlinePlus

Clinical features in Patients 1, 3 and 4.a: Multiple reddish-brown macules on the back in Patient 1.b: A brown nodule on the right side of abdomen in Patient 3.c: Multiple brown macules on the extremities in Patient 4.
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fig_001: Clinical features in Patients 1, 3 and 4.a: Multiple reddish-brown macules on the back in Patient 1.b: A brown nodule on the right side of abdomen in Patient 3.c: Multiple brown macules on the extremities in Patient 4.

Mentions: Patient 1: A 1-year-old boy presented with multiple brown macules on the trunk(Fig. 1a). His mother had noticed pigmented macules 8 monthsbefore presentation. Since the number of the region had increased, he was referred to our department.On physical examination, Darier’s sign was positive on the macule. Family histories were unremarkable.Based on clinical and histopathological examinations, a diagnosis of urticaria pigmentosa was made.


The expression of melanoma inhibitory activity on mast cells in child patients with cutaneous mastocytosis.

Ehara Y, Yoshida Y, Tahira M, Yamamoto O - Yonago Acta Med (2014)

Clinical features in Patients 1, 3 and 4.a: Multiple reddish-brown macules on the back in Patient 1.b: A brown nodule on the right side of abdomen in Patient 3.c: Multiple brown macules on the extremities in Patient 4.
© Copyright Policy
Related In: Results  -  Collection

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getmorefigures.php?uid=PMC4209339&req=5

fig_001: Clinical features in Patients 1, 3 and 4.a: Multiple reddish-brown macules on the back in Patient 1.b: A brown nodule on the right side of abdomen in Patient 3.c: Multiple brown macules on the extremities in Patient 4.
Mentions: Patient 1: A 1-year-old boy presented with multiple brown macules on the trunk(Fig. 1a). His mother had noticed pigmented macules 8 monthsbefore presentation. Since the number of the region had increased, he was referred to our department.On physical examination, Darier’s sign was positive on the macule. Family histories were unremarkable.Based on clinical and histopathological examinations, a diagnosis of urticaria pigmentosa was made.

Bottom Line: MIA was positive for infiltrating mast cells in all patients.Serum level of MIA was elevated in 1 patient.Although it was difficult to assess the significance of elevated serum levels of MIA in child patients, MIA was expressed on infiltrating mast cells in our study.

View Article: PubMed Central - PubMed

Affiliation: Division of Dermatology, Department of Medicine of Sensory and Motor Organs, School of Medicine, Tottori University Faculty of Medicine, Yonago 683-8504, Japan.

ABSTRACT

Background: Cutaneous mastocytosis is a disorder characterized by the proliferation of mast cells in the skin. Melanoma inhibitory activity (MIA) is a serum marker for malignant melanoma. However, it has not been known on MIA expression of cutaneous mastocytosis.

Methods: We investigated the expression of MIA in 4 child patients with cutaneous mastocytosis immunohistochemically and serum MIA level in 1 patient by enzyme-linked immunosorbent assay.

Results: Histopathological examination revealed diffuse mast cell infiltration in the dermis. MIA was positive for infiltrating mast cells in all patients. Serum level of MIA was elevated in 1 patient.

Conclusion: Although it was difficult to assess the significance of elevated serum levels of MIA in child patients, MIA was expressed on infiltrating mast cells in our study. Based on our findings, mast cell-derived MIA might be related to the formation of pigmented regions in cutaneous mastocytosis.

No MeSH data available.


Related in: MedlinePlus