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A patient with localized scleroderma successfully treated with etretinate.

Shima T, Yamamoto Y, Ikeda T, Furukawa F - Case Rep Dermatol (2014)

Bottom Line: There are several treatment methods for localized scleroderma, but treatment is difficult when the lesion is widely distributed.We encountered a case who was treated successfully with etretinate, a vitamin A derivative.The usefulness of this agent is discussed.

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology, Wakayama Medical University, Wakayama, Japan.

ABSTRACT
There are several treatment methods for localized scleroderma, but treatment is difficult when the lesion is widely distributed. We encountered a case who was treated successfully with etretinate, a vitamin A derivative. The usefulness of this agent is discussed.

No MeSH data available.


Related in: MedlinePlus

Clinical findings 15 months after the discontinuation of etretinate treatment.
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Figure 3: Clinical findings 15 months after the discontinuation of etretinate treatment.

Mentions: Based on clinical and histopathological findings, the patient was diagnosed with localized scleroderma. Oral treatment with etretinate 20 mg/day was initiated. The reasons for etretinate selection were that she did not want more children and that acitretin or isotretinoin are not approved in Japan. The skin sclerosis started to improve 28 days after treatment initiation. Oral treatment was continued for about 5 months, and the skin sclerosis and pigmentation improved. Topical corticosteroids were not administered during this period, and no adverse events, such as pruritus, skin thinning, gastroenteritis, paronychia or angular cheilitis, developed. 15 months after the discontinuation of etretinate treatment, although the brown pigmentation remained, improvements in skin eruption were maintained compared to those upon first examination (fig. 3).


A patient with localized scleroderma successfully treated with etretinate.

Shima T, Yamamoto Y, Ikeda T, Furukawa F - Case Rep Dermatol (2014)

Clinical findings 15 months after the discontinuation of etretinate treatment.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4209276&req=5

Figure 3: Clinical findings 15 months after the discontinuation of etretinate treatment.
Mentions: Based on clinical and histopathological findings, the patient was diagnosed with localized scleroderma. Oral treatment with etretinate 20 mg/day was initiated. The reasons for etretinate selection were that she did not want more children and that acitretin or isotretinoin are not approved in Japan. The skin sclerosis started to improve 28 days after treatment initiation. Oral treatment was continued for about 5 months, and the skin sclerosis and pigmentation improved. Topical corticosteroids were not administered during this period, and no adverse events, such as pruritus, skin thinning, gastroenteritis, paronychia or angular cheilitis, developed. 15 months after the discontinuation of etretinate treatment, although the brown pigmentation remained, improvements in skin eruption were maintained compared to those upon first examination (fig. 3).

Bottom Line: There are several treatment methods for localized scleroderma, but treatment is difficult when the lesion is widely distributed.We encountered a case who was treated successfully with etretinate, a vitamin A derivative.The usefulness of this agent is discussed.

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology, Wakayama Medical University, Wakayama, Japan.

ABSTRACT
There are several treatment methods for localized scleroderma, but treatment is difficult when the lesion is widely distributed. We encountered a case who was treated successfully with etretinate, a vitamin A derivative. The usefulness of this agent is discussed.

No MeSH data available.


Related in: MedlinePlus