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Successful Treatment of Two Cases of Squamous Cell Carcinoma on the Ear with Intra-Arterial Administration of Peplomycin through a Superficial Temporal Artery.

Haga T, Fujimura T, Takeuchi I, Deguchi M, Aiba S - Case Rep Dermatol (2014)

Bottom Line: Cutaneous squamous cell carcinoma (SCC) is the second most common non-melanoma skin cancer and tends to develop in sun-exposed cosmetic areas, including the ear.In this report, we describe two cases of SCC on the ear successfully treated with intra-arterial administration of peplomycin through a superficial temporal artery.These findings suggest that intra-arterial administration of peplomycin with tegafur is one of the optimal therapies for the treatment of SCC developing on the ear.

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan.

ABSTRACT
Cutaneous squamous cell carcinoma (SCC) is the second most common non-melanoma skin cancer and tends to develop in sun-exposed cosmetic areas, including the ear. In this report, we describe two cases of SCC on the ear successfully treated with intra-arterial administration of peplomycin through a superficial temporal artery. In addition to this selective chemotherapy, we administered oral tegafur, which achieved complete remission of the tumor. These findings suggest that intra-arterial administration of peplomycin with tegafur is one of the optimal therapies for the treatment of SCC developing on the ear.

No MeSH data available.


Related in: MedlinePlus

a A red, dome-shaped nodule with crust on the left ear. b Three weeks after the intra-arterial administration of peplomycin, the tumor had regressed, leaving a scar.
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Figure 3: a A red, dome-shaped nodule with crust on the left ear. b Three weeks after the intra-arterial administration of peplomycin, the tumor had regressed, leaving a scar.

Mentions: A 70-year-old Japanese man visited our outpatient clinic with a 1-month history of a red nodule on his ear. On his initial visit, physical examination revealed a red, dome-shaped nodule with crust on his left ear (fig. 3a). The size was approximately 10 × 10 mm in diameter. A biopsy specimen revealed dermal infiltration of the tumor, which was composed of atypical keratinocytes with dyskeratotic cytoplasm (fig. 4a). The serum SCC Ag was within normal range. We screened for possible internal malignancy with a CT scan but found none. From the above findings, we diagnosed this patient as well-differentiated SCC, and for functional and cosmetic reasons, we selected intra-arterial administration of peplomycin through a superficial temporal artery using an intravascular indwelling catheter. We continuously administered 5 mg peplomycin per day intra-arterially for 9 days. Three weeks after we finished the administration of peplomycin, the tumor mass had rapidly regressed, leaving a scar (fig. 3b). A biopsy specimen revealed that no tumor cells remained at this time point (fig. 4b, c). We added oral administration of 100 mg tegafur for 2 months, and there has been no sign of local recurrence or systemic lesions for 12 months.


Successful Treatment of Two Cases of Squamous Cell Carcinoma on the Ear with Intra-Arterial Administration of Peplomycin through a Superficial Temporal Artery.

Haga T, Fujimura T, Takeuchi I, Deguchi M, Aiba S - Case Rep Dermatol (2014)

a A red, dome-shaped nodule with crust on the left ear. b Three weeks after the intra-arterial administration of peplomycin, the tumor had regressed, leaving a scar.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4209265&req=5

Figure 3: a A red, dome-shaped nodule with crust on the left ear. b Three weeks after the intra-arterial administration of peplomycin, the tumor had regressed, leaving a scar.
Mentions: A 70-year-old Japanese man visited our outpatient clinic with a 1-month history of a red nodule on his ear. On his initial visit, physical examination revealed a red, dome-shaped nodule with crust on his left ear (fig. 3a). The size was approximately 10 × 10 mm in diameter. A biopsy specimen revealed dermal infiltration of the tumor, which was composed of atypical keratinocytes with dyskeratotic cytoplasm (fig. 4a). The serum SCC Ag was within normal range. We screened for possible internal malignancy with a CT scan but found none. From the above findings, we diagnosed this patient as well-differentiated SCC, and for functional and cosmetic reasons, we selected intra-arterial administration of peplomycin through a superficial temporal artery using an intravascular indwelling catheter. We continuously administered 5 mg peplomycin per day intra-arterially for 9 days. Three weeks after we finished the administration of peplomycin, the tumor mass had rapidly regressed, leaving a scar (fig. 3b). A biopsy specimen revealed that no tumor cells remained at this time point (fig. 4b, c). We added oral administration of 100 mg tegafur for 2 months, and there has been no sign of local recurrence or systemic lesions for 12 months.

Bottom Line: Cutaneous squamous cell carcinoma (SCC) is the second most common non-melanoma skin cancer and tends to develop in sun-exposed cosmetic areas, including the ear.In this report, we describe two cases of SCC on the ear successfully treated with intra-arterial administration of peplomycin through a superficial temporal artery.These findings suggest that intra-arterial administration of peplomycin with tegafur is one of the optimal therapies for the treatment of SCC developing on the ear.

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan.

ABSTRACT
Cutaneous squamous cell carcinoma (SCC) is the second most common non-melanoma skin cancer and tends to develop in sun-exposed cosmetic areas, including the ear. In this report, we describe two cases of SCC on the ear successfully treated with intra-arterial administration of peplomycin through a superficial temporal artery. In addition to this selective chemotherapy, we administered oral tegafur, which achieved complete remission of the tumor. These findings suggest that intra-arterial administration of peplomycin with tegafur is one of the optimal therapies for the treatment of SCC developing on the ear.

No MeSH data available.


Related in: MedlinePlus