Limits...
Preservation of neurocognitive function and local control of 1 to 3 brain metastases treated with surgery and carmustine wafers.

Brem S, Meyers CA, Palmer G, Booth-Jones M, Jain S, Ewend MG - Cancer (2013)

Bottom Line: The chemowafers were well tolerated, and serious adverse events were reversible.There was local recurrence in 28% of the patients at 1-year follow-up.Patients with brain metastases had improvements in their cognitive trajectory, especially memory and executive function, after treatment with resection plus CW.

View Article: PubMed Central - PubMed

Affiliation: Department of Neuro-Oncology, Moffitt Cancer Center, Tampa, Florida; Department of Neurosurgery, Perelman School of Medicine, University of Pennsylvania and the Abramson Cancer Center, Philadelphia, Pennsylvania.

Show MeSH

Related in: MedlinePlus

Improvement in neurocognitive function was measured after surgical resection and carmustine wafer placement for brain metastasis using average, standardized Z-scores (indicated as the mean change with 95% confidence interval [CI]). Statistically significant changes were noted in (A) memory (a, P = .001; b, P = .029) and (B) executive function (a, P = .001; b, P = .0007; c [left], P = .041; c [right], P = .018). (C) Fine motor skills.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4209121&req=5

fig03: Improvement in neurocognitive function was measured after surgical resection and carmustine wafer placement for brain metastasis using average, standardized Z-scores (indicated as the mean change with 95% confidence interval [CI]). Statistically significant changes were noted in (A) memory (a, P = .001; b, P = .029) and (B) executive function (a, P = .001; b, P = .0007; c [left], P = .041; c [right], P = .018). (C) Fine motor skills.

Mentions: For the individual domains, the cumulative rates of preservation and worsening of NCF were determined. In the memory domain, 37 of 54 patients (69%) had preservation of NCF (including 26 of 54 patients [48%] who had improvement), 8 of 54 patients (15%) had worsening NCF, and 9 patients were not assessed. In the executive function domain, 39 of 54 patients (72%) had preservation of NCF (including 23 of 54 patients [43%] who had improvement), 4 of 54 patients (7%) had worsening NCF, and 11 patients were not assessed. In the fine motor coordination domain, 34 of 54 patients (63%) had preservation of NCF (including 27 of 54 patients [50%] who had improvement), 11 of 54 patients (20%) had worsening NCF, and 9 patients were not assessed. Mean changes in Z-scores are provided in Figure 3.


Preservation of neurocognitive function and local control of 1 to 3 brain metastases treated with surgery and carmustine wafers.

Brem S, Meyers CA, Palmer G, Booth-Jones M, Jain S, Ewend MG - Cancer (2013)

Improvement in neurocognitive function was measured after surgical resection and carmustine wafer placement for brain metastasis using average, standardized Z-scores (indicated as the mean change with 95% confidence interval [CI]). Statistically significant changes were noted in (A) memory (a, P = .001; b, P = .029) and (B) executive function (a, P = .001; b, P = .0007; c [left], P = .041; c [right], P = .018). (C) Fine motor skills.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4209121&req=5

fig03: Improvement in neurocognitive function was measured after surgical resection and carmustine wafer placement for brain metastasis using average, standardized Z-scores (indicated as the mean change with 95% confidence interval [CI]). Statistically significant changes were noted in (A) memory (a, P = .001; b, P = .029) and (B) executive function (a, P = .001; b, P = .0007; c [left], P = .041; c [right], P = .018). (C) Fine motor skills.
Mentions: For the individual domains, the cumulative rates of preservation and worsening of NCF were determined. In the memory domain, 37 of 54 patients (69%) had preservation of NCF (including 26 of 54 patients [48%] who had improvement), 8 of 54 patients (15%) had worsening NCF, and 9 patients were not assessed. In the executive function domain, 39 of 54 patients (72%) had preservation of NCF (including 23 of 54 patients [43%] who had improvement), 4 of 54 patients (7%) had worsening NCF, and 11 patients were not assessed. In the fine motor coordination domain, 34 of 54 patients (63%) had preservation of NCF (including 27 of 54 patients [50%] who had improvement), 11 of 54 patients (20%) had worsening NCF, and 9 patients were not assessed. Mean changes in Z-scores are provided in Figure 3.

Bottom Line: The chemowafers were well tolerated, and serious adverse events were reversible.There was local recurrence in 28% of the patients at 1-year follow-up.Patients with brain metastases had improvements in their cognitive trajectory, especially memory and executive function, after treatment with resection plus CW.

View Article: PubMed Central - PubMed

Affiliation: Department of Neuro-Oncology, Moffitt Cancer Center, Tampa, Florida; Department of Neurosurgery, Perelman School of Medicine, University of Pennsylvania and the Abramson Cancer Center, Philadelphia, Pennsylvania.

Show MeSH
Related in: MedlinePlus