Agreement between allergen-specific IgE assays and ensuing immunotherapy recommendations from four commercial laboratories in the USA.
Bottom Line: The overall chance-corrected agreement of the positive/negative test results for ungrouped and grouped allergens was slight (κ = 0.14 and 0.13, respectively).Subset analysis of the laboratory pair with the highest level of diagnostic agreement (κ = 0.36) found slight agreement (κ = 0.13) for ungrouped plants and fungi, but substantial agreement (κ = 0.71) for ungrouped mites.Altogether, 85.1% of ungrouped allergen treatment recommendations were unique to one laboratory or another.
Affiliation: SkinVet Clinic, 15800 SW Upper Boones Ferry Road, Suite 120, Lake Oswego, OR, 97035, USA.Show MeSH
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Mentions: The best chance-corrected agreement was found between Labs C and D (κ = 0.36, fair). Nine of the 12 positive agreements between Labs C and D across the 10 dogs were for mites. Subset analysis of Labs C and D found 86% agreement (κ = 0.13, slight) for ungrouped plants and fungi, and 87% agreement (κ = 0.71, substantial) for ungrouped mites (Figure3). The κ values can be characterized as slight or fair for all other between-laboratory comparisons of diagnostics on ungrouped antigens limited to either plants and fungi or mites (Figure3).
Affiliation: SkinVet Clinic, 15800 SW Upper Boones Ferry Road, Suite 120, Lake Oswego, OR, 97035, USA.