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Target antigens for perinuclear antineutrophil cytoplasmic antibodies in Iranian patients with ulcerative colitis.

Bahari A, Aarabi M, Hedayati M, Jarollahi A, Firouzi F, Aghazadeh R, Zali MR, Bari Z, Hashemi M, Esmaeilzadeh A, Mokhtarifar A, Ganji A - Middle East J Dig Dis (2014)

Bottom Line: RESULTS 59.2% of the patients were positive for at least one antigen and p-ANCA directed against lactoferrin, elastase, lysozyme, cathepsin G, Bactericidal permeability increasing protein, and myeloproxidase in 31.5%, 25.9%, 8.3%, 7.4%, 5.6%, and 0% of the patients, respectively.CONCLUSION The highest prevalence of p-ANCA was observed against lactoferrin and elastase.Also, myeloproxidase was not an antigen for p-ANCA among our patients.

View Article: PubMed Central - HTML - PubMed

Affiliation: Endoscopic & Minimally Invasive Surgery Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

ABSTRACT

Unlabelled: BACKGROUND Patients with ulcerative colitis (UC) carry autoantibodies such as perinuclear antineutrophil cytoplasmic antibodies (p-ANCA).

Objective: The aim of the present study was to evaluate the target antigens for p-ANCA in Iranian patients with UC. METHODS p-ANCA target antigens including elastase, lactoferrin, cathepsin G, myeloproxidase, lysozyme, and bactericidal permeability increasing protein (BPI) were determined in 113 patients with UC using enzyme-linked immunosorbent assay (ELISA). RESULTS 59.2% of the patients were positive for at least one antigen and p-ANCA directed against lactoferrin, elastase, lysozyme, cathepsin G, Bactericidal permeability increasing protein, and myeloproxidase in 31.5%, 25.9%, 8.3%, 7.4%, 5.6%, and 0% of the patients, respectively. CONCLUSION The highest prevalence of p-ANCA was observed against lactoferrin and elastase. Also, myeloproxidase was not an antigen for p-ANCA among our patients.

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Mentions: One hundred and eight patients completed the study. In order to find the target antigens for antineutrophil cytoplasmic antibody among the patients with UC, we did ELISA to find autoantibody against lactoferrin, elastase, lysozyme, cathepsin G, BPI, and myeloproxidase (MPO). As shown in figure 1, the prevalence of auto-antibodies against lactoferrin, elastase, lysozyme, cathepsin G, BPI, and myeloproxidase (MPO) were 31.5%, 25.9%, 8.3%, 7.4%, 5.6% and 0%, respectively.


Target antigens for perinuclear antineutrophil cytoplasmic antibodies in Iranian patients with ulcerative colitis.

Bahari A, Aarabi M, Hedayati M, Jarollahi A, Firouzi F, Aghazadeh R, Zali MR, Bari Z, Hashemi M, Esmaeilzadeh A, Mokhtarifar A, Ganji A - Middle East J Dig Dis (2014)

© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4208928&req=5

Mentions: One hundred and eight patients completed the study. In order to find the target antigens for antineutrophil cytoplasmic antibody among the patients with UC, we did ELISA to find autoantibody against lactoferrin, elastase, lysozyme, cathepsin G, BPI, and myeloproxidase (MPO). As shown in figure 1, the prevalence of auto-antibodies against lactoferrin, elastase, lysozyme, cathepsin G, BPI, and myeloproxidase (MPO) were 31.5%, 25.9%, 8.3%, 7.4%, 5.6% and 0%, respectively.

Bottom Line: RESULTS 59.2% of the patients were positive for at least one antigen and p-ANCA directed against lactoferrin, elastase, lysozyme, cathepsin G, Bactericidal permeability increasing protein, and myeloproxidase in 31.5%, 25.9%, 8.3%, 7.4%, 5.6%, and 0% of the patients, respectively.CONCLUSION The highest prevalence of p-ANCA was observed against lactoferrin and elastase.Also, myeloproxidase was not an antigen for p-ANCA among our patients.

View Article: PubMed Central - HTML - PubMed

Affiliation: Endoscopic & Minimally Invasive Surgery Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

ABSTRACT

Unlabelled: BACKGROUND Patients with ulcerative colitis (UC) carry autoantibodies such as perinuclear antineutrophil cytoplasmic antibodies (p-ANCA).

Objective: The aim of the present study was to evaluate the target antigens for p-ANCA in Iranian patients with UC. METHODS p-ANCA target antigens including elastase, lactoferrin, cathepsin G, myeloproxidase, lysozyme, and bactericidal permeability increasing protein (BPI) were determined in 113 patients with UC using enzyme-linked immunosorbent assay (ELISA). RESULTS 59.2% of the patients were positive for at least one antigen and p-ANCA directed against lactoferrin, elastase, lysozyme, cathepsin G, Bactericidal permeability increasing protein, and myeloproxidase in 31.5%, 25.9%, 8.3%, 7.4%, 5.6%, and 0% of the patients, respectively. CONCLUSION The highest prevalence of p-ANCA was observed against lactoferrin and elastase. Also, myeloproxidase was not an antigen for p-ANCA among our patients.

No MeSH data available.


Related in: MedlinePlus