Limits...
The effects of aging on the functional and structural properties of the rat basilar artery.

Tümer N, Toklu HZ, Muller-Delp JM, Oktay S, Ghosh P, Strang K, Delp MD, Scarpace PJ - Physiol Rep (2014)

Bottom Line: The aim of this study was to evaluate the effects of aging on cerebral vascular function and structure.Advanced aging (24 months) decreased responses of the basilar artery to both the contractile and relaxing agents; whereas, DEA-induced dilation was significantly higher in the 8-month-old group compared with the younger and older groups.These findings indicate that aging produces dysfunction of both the endothelium and the vascular smooth muscle in the basilar artery.

View Article: PubMed Central - PubMed

Affiliation: Geriatric Research, Education, and Clinical Center, North Florida/South Georgia Veterans Health System, Gainesville, Florida, USA Department of Pharmacology and Therapeutics, University of Florida, Gainesville, Florida, USA.

No MeSH data available.


Related in: MedlinePlus

Serum total antioxidant capacity (tAOC) of the 3‐, 8‐, and 24‐month‐old rats (six per group). *P <0.05 3 months versus 24 months; +P <0.05 8 months versus 24 months.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4208653&req=5

fig04: Serum total antioxidant capacity (tAOC) of the 3‐, 8‐, and 24‐month‐old rats (six per group). *P <0.05 3 months versus 24 months; +P <0.05 8 months versus 24 months.

Mentions: Serum antioxidant capacity was significantly decreased in 24‐month‐olds when compared with 3‐ and 8‐month‐old rats (Fig. 4).


The effects of aging on the functional and structural properties of the rat basilar artery.

Tümer N, Toklu HZ, Muller-Delp JM, Oktay S, Ghosh P, Strang K, Delp MD, Scarpace PJ - Physiol Rep (2014)

Serum total antioxidant capacity (tAOC) of the 3‐, 8‐, and 24‐month‐old rats (six per group). *P <0.05 3 months versus 24 months; +P <0.05 8 months versus 24 months.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4208653&req=5

fig04: Serum total antioxidant capacity (tAOC) of the 3‐, 8‐, and 24‐month‐old rats (six per group). *P <0.05 3 months versus 24 months; +P <0.05 8 months versus 24 months.
Mentions: Serum antioxidant capacity was significantly decreased in 24‐month‐olds when compared with 3‐ and 8‐month‐old rats (Fig. 4).

Bottom Line: The aim of this study was to evaluate the effects of aging on cerebral vascular function and structure.Advanced aging (24 months) decreased responses of the basilar artery to both the contractile and relaxing agents; whereas, DEA-induced dilation was significantly higher in the 8-month-old group compared with the younger and older groups.These findings indicate that aging produces dysfunction of both the endothelium and the vascular smooth muscle in the basilar artery.

View Article: PubMed Central - PubMed

Affiliation: Geriatric Research, Education, and Clinical Center, North Florida/South Georgia Veterans Health System, Gainesville, Florida, USA Department of Pharmacology and Therapeutics, University of Florida, Gainesville, Florida, USA.

No MeSH data available.


Related in: MedlinePlus