Transcriptome analysis of CNS immediately before and after the detection of PrP(Sc) in SSBP/1 sheep scrapie.
Bottom Line: Several neurological receptors were significantly increased at D75 (e.g. CHRNA6, GRM1, HCN2), which might be clues to the molecular basis of psychiatric changes associated with TSEs.No genes were significantly differentially expressed at both D75 and D125 and there was no progression of events from earlier to later time points.There seems to be a step-change between D75 and D125, correlating with the detection of PrP(Sc), resulting in the involvement of different pathological processes in later TSE disease.
Affiliation: The Roslin Institute & R(D)SVS, University of Edinburgh, Easter Bush, Midlothian, Edinburgh EH25 9RG, UK.Show MeSH
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Affiliation: The Roslin Institute & R(D)SVS, University of Edinburgh, Easter Bush, Midlothian, Edinburgh EH25 9RG, UK.