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Prognostic role of common microRNA polymorphisms in cancers: evidence from a meta-analysis.

Xia L, Ren Y, Fang X, Yin Z, Li X, Wu W, Guan P, Zhou B - PLoS ONE (2014)

Bottom Line: The same result exists in Asian population, in Non-Small Cell Lung Cancer and digestive cancer.No significant results are obtained for mir-499 polymorphisms.Genetic polymorphisms in mir-146a, mir-196a2 and mir-149 may be associated with overall survival.

View Article: PubMed Central - PubMed

Affiliation: Department of Epidemiology, School of Public Health, China Medical University, Shenyang, Liaoning Province, China; Key Laboratory of Cancer Etiology and Intervention, University of Liaoning Province, Shenyang, China.

ABSTRACT

Background: The morbidity and mortality of cancer increase remarkably every year. It's a heavy burden for family and society. The detection of prognostic biomarkers can help to improve the theraputic effect and prolong the lifetime of patients. microRNAs have an influential role in cancer prognosis. The results of articles discussing the relationship between microRNA polymorphisms and cancer prognosis are inconsistent.

Methods: We conduct a meta-analysis of 19 publications concerning the association of four common polymorphisms, mir-146a rs2910164, mir-149 rs2292832, mir-196a2 rs11614913 and mir-499 rs3746444, with cancer prognosis. Pooled Hazard Ratios with 95% Confidence Intervals for the relationship between four genetic polymorphisms and Overall Survival, Recurrence-free Survival, Disease-free survival, recurrence are calculated. Subgroup analysis by population and type of tumor are conducted.

Results: GG genotype of mir-146a may be the protective factor for overall survival, especially in Caucasian population. C-containing genotypes of mir-196a2 act as a risk role for overall survival. The same result exists in Asian population, in Non-Small Cell Lung Cancer and digestive cancer. The patients with C allele of mir-149 have a better overall survival, especially in Non-Small Cell Lung Cancer. No significant results are obtained for mir-499 polymorphisms.

Conclusions: Genetic polymorphisms in mir-146a, mir-196a2 and mir-149 may be associated with overall survival. This effect varies with different types of cancer. Genetic polymorphism in mir-499 may have nothing to do with cancer prognosis.

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Related in: MedlinePlus

Funnel plots for the four genetic polymorphisms.Funnel plots of the publication bias for mir-146a in Dominant model(a), mir-196a2 in Recessive model(b), mir-149 in Dominant model(c) and mir-499 in AG vs AA(d).
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pone-0106799-g003: Funnel plots for the four genetic polymorphisms.Funnel plots of the publication bias for mir-146a in Dominant model(a), mir-196a2 in Recessive model(b), mir-149 in Dominant model(c) and mir-499 in AG vs AA(d).

Mentions: The meta-analysis results for relationship between polymorphisms and cancer overall survival are summarized in Table 1. The forest plot and funnel plot are listed in Figure 2 and Figure 3. The results of subgroup analysis by original population are summarized in Table 2 and the results of subgroup analysis by type of tumor are summarized in Table 3.


Prognostic role of common microRNA polymorphisms in cancers: evidence from a meta-analysis.

Xia L, Ren Y, Fang X, Yin Z, Li X, Wu W, Guan P, Zhou B - PLoS ONE (2014)

Funnel plots for the four genetic polymorphisms.Funnel plots of the publication bias for mir-146a in Dominant model(a), mir-196a2 in Recessive model(b), mir-149 in Dominant model(c) and mir-499 in AG vs AA(d).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4206268&req=5

pone-0106799-g003: Funnel plots for the four genetic polymorphisms.Funnel plots of the publication bias for mir-146a in Dominant model(a), mir-196a2 in Recessive model(b), mir-149 in Dominant model(c) and mir-499 in AG vs AA(d).
Mentions: The meta-analysis results for relationship between polymorphisms and cancer overall survival are summarized in Table 1. The forest plot and funnel plot are listed in Figure 2 and Figure 3. The results of subgroup analysis by original population are summarized in Table 2 and the results of subgroup analysis by type of tumor are summarized in Table 3.

Bottom Line: The same result exists in Asian population, in Non-Small Cell Lung Cancer and digestive cancer.No significant results are obtained for mir-499 polymorphisms.Genetic polymorphisms in mir-146a, mir-196a2 and mir-149 may be associated with overall survival.

View Article: PubMed Central - PubMed

Affiliation: Department of Epidemiology, School of Public Health, China Medical University, Shenyang, Liaoning Province, China; Key Laboratory of Cancer Etiology and Intervention, University of Liaoning Province, Shenyang, China.

ABSTRACT

Background: The morbidity and mortality of cancer increase remarkably every year. It's a heavy burden for family and society. The detection of prognostic biomarkers can help to improve the theraputic effect and prolong the lifetime of patients. microRNAs have an influential role in cancer prognosis. The results of articles discussing the relationship between microRNA polymorphisms and cancer prognosis are inconsistent.

Methods: We conduct a meta-analysis of 19 publications concerning the association of four common polymorphisms, mir-146a rs2910164, mir-149 rs2292832, mir-196a2 rs11614913 and mir-499 rs3746444, with cancer prognosis. Pooled Hazard Ratios with 95% Confidence Intervals for the relationship between four genetic polymorphisms and Overall Survival, Recurrence-free Survival, Disease-free survival, recurrence are calculated. Subgroup analysis by population and type of tumor are conducted.

Results: GG genotype of mir-146a may be the protective factor for overall survival, especially in Caucasian population. C-containing genotypes of mir-196a2 act as a risk role for overall survival. The same result exists in Asian population, in Non-Small Cell Lung Cancer and digestive cancer. The patients with C allele of mir-149 have a better overall survival, especially in Non-Small Cell Lung Cancer. No significant results are obtained for mir-499 polymorphisms.

Conclusions: Genetic polymorphisms in mir-146a, mir-196a2 and mir-149 may be associated with overall survival. This effect varies with different types of cancer. Genetic polymorphism in mir-499 may have nothing to do with cancer prognosis.

Show MeSH
Related in: MedlinePlus