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Prognostic role of common microRNA polymorphisms in cancers: evidence from a meta-analysis.

Xia L, Ren Y, Fang X, Yin Z, Li X, Wu W, Guan P, Zhou B - PLoS ONE (2014)

Bottom Line: The same result exists in Asian population, in Non-Small Cell Lung Cancer and digestive cancer.No significant results are obtained for mir-499 polymorphisms.Genetic polymorphisms in mir-146a, mir-196a2 and mir-149 may be associated with overall survival.

View Article: PubMed Central - PubMed

Affiliation: Department of Epidemiology, School of Public Health, China Medical University, Shenyang, Liaoning Province, China; Key Laboratory of Cancer Etiology and Intervention, University of Liaoning Province, Shenyang, China.

ABSTRACT

Background: The morbidity and mortality of cancer increase remarkably every year. It's a heavy burden for family and society. The detection of prognostic biomarkers can help to improve the theraputic effect and prolong the lifetime of patients. microRNAs have an influential role in cancer prognosis. The results of articles discussing the relationship between microRNA polymorphisms and cancer prognosis are inconsistent.

Methods: We conduct a meta-analysis of 19 publications concerning the association of four common polymorphisms, mir-146a rs2910164, mir-149 rs2292832, mir-196a2 rs11614913 and mir-499 rs3746444, with cancer prognosis. Pooled Hazard Ratios with 95% Confidence Intervals for the relationship between four genetic polymorphisms and Overall Survival, Recurrence-free Survival, Disease-free survival, recurrence are calculated. Subgroup analysis by population and type of tumor are conducted.

Results: GG genotype of mir-146a may be the protective factor for overall survival, especially in Caucasian population. C-containing genotypes of mir-196a2 act as a risk role for overall survival. The same result exists in Asian population, in Non-Small Cell Lung Cancer and digestive cancer. The patients with C allele of mir-149 have a better overall survival, especially in Non-Small Cell Lung Cancer. No significant results are obtained for mir-499 polymorphisms.

Conclusions: Genetic polymorphisms in mir-146a, mir-196a2 and mir-149 may be associated with overall survival. This effect varies with different types of cancer. Genetic polymorphism in mir-499 may have nothing to do with cancer prognosis.

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Related in: MedlinePlus

The flowchart of the selection process.We utilized a comprehensive searching strategy to screen out potential related articles as far as possible. 26 articles focusing on the association between the four genetic polymorphisms and cancer prognosis are screened out. 7 articles are excluded in quantitative ananlysis for lack of data to calculate pooled HR and 95%CI.
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pone-0106799-g001: The flowchart of the selection process.We utilized a comprehensive searching strategy to screen out potential related articles as far as possible. 26 articles focusing on the association between the four genetic polymorphisms and cancer prognosis are screened out. 7 articles are excluded in quantitative ananlysis for lack of data to calculate pooled HR and 95%CI.

Mentions: The flow diagram of the study selection process is presented in Figure 1. Nineteen [7], [23], [24], [28]–[43] eligible publications are included in this meta-analysis with 8890 patients totally. Seven [44]–[50] are excluded for lack of data and precise genotypes. These eligible articles were published from 2008 to 2014. Twelve [23], [24], [28]–[35], [37], [43] studies concerning the relationship between mir-146a polymorphism and cancer prognosis. Of them, nine articles focus on the relationship with overall survival, one on the relationship with recurrence, three on relationship with recurrence-free survival(RFS) and three on relationship with disease-free survival(DFS). The number of the articles concerning the relationship between polymorphisms in mir-196a2, mir-149 and mir-499 and cancer prognosis is respectively fourteen [7], [24], [29]–[31], [33]–[35], [37]–[41], [43], eight [24], [29], [31], [33], [34], [36], [37], [42] and seven [24], [29]–[31], [33], [34], [37]. The original population contain American, Korean, Chinese, Indian, Spainish and German. The type of tumor covers colorectal cancer (CRC), gastric cancer (GC), non-small cell lung cancer (NSCLC), esophageal squamous cell carcinoma (ESCC), hepatocellular carcinoma (HCC), bladder cancer, squamous cell carcinoma of prostate (SCCOP), head and neck squamous cell carcinoma (HNSCC), hodgkin lymphomam, nasopharyngeal and malignant lymphoma. Characteristics of eligible articles are summarized in Table S1. The original data for this meta-analysis are listed in Table S2.


Prognostic role of common microRNA polymorphisms in cancers: evidence from a meta-analysis.

Xia L, Ren Y, Fang X, Yin Z, Li X, Wu W, Guan P, Zhou B - PLoS ONE (2014)

The flowchart of the selection process.We utilized a comprehensive searching strategy to screen out potential related articles as far as possible. 26 articles focusing on the association between the four genetic polymorphisms and cancer prognosis are screened out. 7 articles are excluded in quantitative ananlysis for lack of data to calculate pooled HR and 95%CI.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4206268&req=5

pone-0106799-g001: The flowchart of the selection process.We utilized a comprehensive searching strategy to screen out potential related articles as far as possible. 26 articles focusing on the association between the four genetic polymorphisms and cancer prognosis are screened out. 7 articles are excluded in quantitative ananlysis for lack of data to calculate pooled HR and 95%CI.
Mentions: The flow diagram of the study selection process is presented in Figure 1. Nineteen [7], [23], [24], [28]–[43] eligible publications are included in this meta-analysis with 8890 patients totally. Seven [44]–[50] are excluded for lack of data and precise genotypes. These eligible articles were published from 2008 to 2014. Twelve [23], [24], [28]–[35], [37], [43] studies concerning the relationship between mir-146a polymorphism and cancer prognosis. Of them, nine articles focus on the relationship with overall survival, one on the relationship with recurrence, three on relationship with recurrence-free survival(RFS) and three on relationship with disease-free survival(DFS). The number of the articles concerning the relationship between polymorphisms in mir-196a2, mir-149 and mir-499 and cancer prognosis is respectively fourteen [7], [24], [29]–[31], [33]–[35], [37]–[41], [43], eight [24], [29], [31], [33], [34], [36], [37], [42] and seven [24], [29]–[31], [33], [34], [37]. The original population contain American, Korean, Chinese, Indian, Spainish and German. The type of tumor covers colorectal cancer (CRC), gastric cancer (GC), non-small cell lung cancer (NSCLC), esophageal squamous cell carcinoma (ESCC), hepatocellular carcinoma (HCC), bladder cancer, squamous cell carcinoma of prostate (SCCOP), head and neck squamous cell carcinoma (HNSCC), hodgkin lymphomam, nasopharyngeal and malignant lymphoma. Characteristics of eligible articles are summarized in Table S1. The original data for this meta-analysis are listed in Table S2.

Bottom Line: The same result exists in Asian population, in Non-Small Cell Lung Cancer and digestive cancer.No significant results are obtained for mir-499 polymorphisms.Genetic polymorphisms in mir-146a, mir-196a2 and mir-149 may be associated with overall survival.

View Article: PubMed Central - PubMed

Affiliation: Department of Epidemiology, School of Public Health, China Medical University, Shenyang, Liaoning Province, China; Key Laboratory of Cancer Etiology and Intervention, University of Liaoning Province, Shenyang, China.

ABSTRACT

Background: The morbidity and mortality of cancer increase remarkably every year. It's a heavy burden for family and society. The detection of prognostic biomarkers can help to improve the theraputic effect and prolong the lifetime of patients. microRNAs have an influential role in cancer prognosis. The results of articles discussing the relationship between microRNA polymorphisms and cancer prognosis are inconsistent.

Methods: We conduct a meta-analysis of 19 publications concerning the association of four common polymorphisms, mir-146a rs2910164, mir-149 rs2292832, mir-196a2 rs11614913 and mir-499 rs3746444, with cancer prognosis. Pooled Hazard Ratios with 95% Confidence Intervals for the relationship between four genetic polymorphisms and Overall Survival, Recurrence-free Survival, Disease-free survival, recurrence are calculated. Subgroup analysis by population and type of tumor are conducted.

Results: GG genotype of mir-146a may be the protective factor for overall survival, especially in Caucasian population. C-containing genotypes of mir-196a2 act as a risk role for overall survival. The same result exists in Asian population, in Non-Small Cell Lung Cancer and digestive cancer. The patients with C allele of mir-149 have a better overall survival, especially in Non-Small Cell Lung Cancer. No significant results are obtained for mir-499 polymorphisms.

Conclusions: Genetic polymorphisms in mir-146a, mir-196a2 and mir-149 may be associated with overall survival. This effect varies with different types of cancer. Genetic polymorphism in mir-499 may have nothing to do with cancer prognosis.

Show MeSH
Related in: MedlinePlus