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Depression in small-vessel disease relates to white matter ultrastructural damage, not disability.

Brookes RL, Herbert V, Lawrence AJ, Morris RG, Markus HS - Neurology (2014)

Bottom Line: We then compared the same model in a non-SVD stroke cohort (n = 50) and healthy older adults (n = 203).The DTI study showed that fractional anisotropy, a marker of white matter damage, was related to depressive symptoms in patients with SVD.These results suggest that in stroke patients without SVD, disability is an important causal factor for depression, whereas in SVD stroke, other factors specific to this stroke subtype have a causal role.

View Article: PubMed Central - PubMed

Affiliation: From the Stroke and Dementia Research Centre (R.L.B., V.H., A.J.L.), St George's, University of London; University of Cambridge (H.S.M.), Department of Neurology, Cambridge Biomedical Campus; and Department of Psychology (R.G.M.), Institute of Psychiatry, King's College London, UK. rbrookes@sgul.ac.uk.

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Control modelReplication analysis in a healthy older adult group. Standardized β weights are shown for each path. **Significant at the 0.001 level. ADL = Activities of Daily Living; mRS = modified Rankin Scale; QoL = quality of life.
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Figure 3: Control modelReplication analysis in a healthy older adult group. Standardized β weights are shown for each path. **Significant at the 0.001 level. ADL = Activities of Daily Living; mRS = modified Rankin Scale; QoL = quality of life.

Mentions: The results for the control group showed significant paths from depression to QoL (β = 0.45, p = 0.003; 95% CI = 0.26, 0.60), disability to QoL (β = 0.43, p = 0.002; 95% CI = 0.23, 0.63), and from disability to depression (β = 0.32, p = 0.007; 95% CI = 0.10, 0.59). There was also a significant indirect effect of disability on QoL via depression (β = 0.14, p = 0.004; 95% CI = 0.05, 0.26). See figure 3.


Depression in small-vessel disease relates to white matter ultrastructural damage, not disability.

Brookes RL, Herbert V, Lawrence AJ, Morris RG, Markus HS - Neurology (2014)

Control modelReplication analysis in a healthy older adult group. Standardized β weights are shown for each path. **Significant at the 0.001 level. ADL = Activities of Daily Living; mRS = modified Rankin Scale; QoL = quality of life.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4206159&req=5

Figure 3: Control modelReplication analysis in a healthy older adult group. Standardized β weights are shown for each path. **Significant at the 0.001 level. ADL = Activities of Daily Living; mRS = modified Rankin Scale; QoL = quality of life.
Mentions: The results for the control group showed significant paths from depression to QoL (β = 0.45, p = 0.003; 95% CI = 0.26, 0.60), disability to QoL (β = 0.43, p = 0.002; 95% CI = 0.23, 0.63), and from disability to depression (β = 0.32, p = 0.007; 95% CI = 0.10, 0.59). There was also a significant indirect effect of disability on QoL via depression (β = 0.14, p = 0.004; 95% CI = 0.05, 0.26). See figure 3.

Bottom Line: We then compared the same model in a non-SVD stroke cohort (n = 50) and healthy older adults (n = 203).The DTI study showed that fractional anisotropy, a marker of white matter damage, was related to depressive symptoms in patients with SVD.These results suggest that in stroke patients without SVD, disability is an important causal factor for depression, whereas in SVD stroke, other factors specific to this stroke subtype have a causal role.

View Article: PubMed Central - PubMed

Affiliation: From the Stroke and Dementia Research Centre (R.L.B., V.H., A.J.L.), St George's, University of London; University of Cambridge (H.S.M.), Department of Neurology, Cambridge Biomedical Campus; and Department of Psychology (R.G.M.), Institute of Psychiatry, King's College London, UK. rbrookes@sgul.ac.uk.

Show MeSH
Related in: MedlinePlus