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Depression in small-vessel disease relates to white matter ultrastructural damage, not disability.

Brookes RL, Herbert V, Lawrence AJ, Morris RG, Markus HS - Neurology (2014)

Bottom Line: We then compared the same model in a non-SVD stroke cohort (n = 50) and healthy older adults (n = 203).The DTI study showed that fractional anisotropy, a marker of white matter damage, was related to depressive symptoms in patients with SVD.These results suggest that in stroke patients without SVD, disability is an important causal factor for depression, whereas in SVD stroke, other factors specific to this stroke subtype have a causal role.

View Article: PubMed Central - PubMed

Affiliation: From the Stroke and Dementia Research Centre (R.L.B., V.H., A.J.L.), St George's, University of London; University of Cambridge (H.S.M.), Department of Neurology, Cambridge Biomedical Campus; and Department of Psychology (R.G.M.), Institute of Psychiatry, King's College London, UK. rbrookes@sgul.ac.uk.

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Non-SVD stroke modelReplication analysis in a non-SVD stroke patient group. Standardized β weights are shown for each path. *Significant at the 0.05 level; **significant at the 0.001 level. ADL = Activities of Daily Living; mRS = modified Rankin Scale; QoL = quality of life; SVD = small-vessel disease.
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Figure 2: Non-SVD stroke modelReplication analysis in a non-SVD stroke patient group. Standardized β weights are shown for each path. *Significant at the 0.05 level; **significant at the 0.001 level. ADL = Activities of Daily Living; mRS = modified Rankin Scale; QoL = quality of life; SVD = small-vessel disease.

Mentions: When the same model was applied to the non-SVD stroke group, there was a different pattern of results to that seen in SVD. The direct path from depression to QoL was highly significant (β = 0.67, p < 0.001; 95% CI = 0.22, 0.88) and the direct path from disability to QoL was significant (β = 0.25, p < 0.05; 95% CI = 0.01, 0.57). In addition, the non-SVD group showed a highly significant path from disability to depression (β = 0.47, p < 0.05; 95% CI = 0.07, 0.74) and a significant indirect path from disability to QoL via depression (β = 0.31, p = 0.01; 95% CI = 0.13, 0.55). See figure 2.


Depression in small-vessel disease relates to white matter ultrastructural damage, not disability.

Brookes RL, Herbert V, Lawrence AJ, Morris RG, Markus HS - Neurology (2014)

Non-SVD stroke modelReplication analysis in a non-SVD stroke patient group. Standardized β weights are shown for each path. *Significant at the 0.05 level; **significant at the 0.001 level. ADL = Activities of Daily Living; mRS = modified Rankin Scale; QoL = quality of life; SVD = small-vessel disease.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4206159&req=5

Figure 2: Non-SVD stroke modelReplication analysis in a non-SVD stroke patient group. Standardized β weights are shown for each path. *Significant at the 0.05 level; **significant at the 0.001 level. ADL = Activities of Daily Living; mRS = modified Rankin Scale; QoL = quality of life; SVD = small-vessel disease.
Mentions: When the same model was applied to the non-SVD stroke group, there was a different pattern of results to that seen in SVD. The direct path from depression to QoL was highly significant (β = 0.67, p < 0.001; 95% CI = 0.22, 0.88) and the direct path from disability to QoL was significant (β = 0.25, p < 0.05; 95% CI = 0.01, 0.57). In addition, the non-SVD group showed a highly significant path from disability to depression (β = 0.47, p < 0.05; 95% CI = 0.07, 0.74) and a significant indirect path from disability to QoL via depression (β = 0.31, p = 0.01; 95% CI = 0.13, 0.55). See figure 2.

Bottom Line: We then compared the same model in a non-SVD stroke cohort (n = 50) and healthy older adults (n = 203).The DTI study showed that fractional anisotropy, a marker of white matter damage, was related to depressive symptoms in patients with SVD.These results suggest that in stroke patients without SVD, disability is an important causal factor for depression, whereas in SVD stroke, other factors specific to this stroke subtype have a causal role.

View Article: PubMed Central - PubMed

Affiliation: From the Stroke and Dementia Research Centre (R.L.B., V.H., A.J.L.), St George's, University of London; University of Cambridge (H.S.M.), Department of Neurology, Cambridge Biomedical Campus; and Department of Psychology (R.G.M.), Institute of Psychiatry, King's College London, UK. rbrookes@sgul.ac.uk.

Show MeSH
Related in: MedlinePlus