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Towards a unified theory of health-disease: II. Holopathogenesis.

Almeida Filho N - Rev Saude Publica (2014)

Bottom Line: First, a conceptual background of Holopathogenesis is presented as a series of significant interfaces (biomolecular-immunological, physiopathological-clinical, epidemiological-ecosocial).Third, a formalization of intra- and inter-level correspondences, over-determination processes, effects and links of Holopathogenesis models is proposed.Finally, the Holopathogenesis frame is evaluated as a comprehensive theoretical pathology taken as a preliminary step towards a unified theory of health-disease.

View Article: PubMed Central - PubMed

Affiliation: Instituto de Saúde Coletiva, Universidade Federal da Bahia, Salvador, BA, Brasil.

ABSTRACT
This article presents a systematic framework for modeling several classes of illness-sickness-disease named as Holopathogenesis. Holopathogenesis is defined as processes of over-determination of diseases and related conditions taken as a whole, comprising selected facets of the complex object Health. First, a conceptual background of Holopathogenesis is presented as a series of significant interfaces (biomolecular-immunological, physiopathological-clinical, epidemiological-ecosocial). Second, propositions derived from Holopathogenesis are introduced in order to allow drawing the disease-illness-sickness complex as a hierarchical network of networks. Third, a formalization of intra- and inter-level correspondences, over-determination processes, effects and links of Holopathogenesis models is proposed. Finally, the Holopathogenesis frame is evaluated as a comprehensive theoretical pathology taken as a preliminary step towards a unified theory of health-disease.

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Research areas of interest in the complex Disease-Illness-Sickness.
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f06: Research areas of interest in the complex Disease-Illness-Sickness.

Mentions: The concrete forms of these operations will be drawn out of available empirical datain each dimension/level/facet of HPG, as much as from the accuracy with which thedifferent models will be able to reproduce and predict situations observed inconcrete health situations. In this regard, HPG mapping also permits the visualrepresentation of the influence of research areas and categories on the cDIS model.This is illustrated in Figure 6, where it isgraphically demonstrated how limited in scope and relevance are biomolecularresearch targets as compared to environmental and sociocultural conditions for theover-determination of health-disease outcomes.


Towards a unified theory of health-disease: II. Holopathogenesis.

Almeida Filho N - Rev Saude Publica (2014)

Research areas of interest in the complex Disease-Illness-Sickness.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4206141&req=5

f06: Research areas of interest in the complex Disease-Illness-Sickness.
Mentions: The concrete forms of these operations will be drawn out of available empirical datain each dimension/level/facet of HPG, as much as from the accuracy with which thedifferent models will be able to reproduce and predict situations observed inconcrete health situations. In this regard, HPG mapping also permits the visualrepresentation of the influence of research areas and categories on the cDIS model.This is illustrated in Figure 6, where it isgraphically demonstrated how limited in scope and relevance are biomolecularresearch targets as compared to environmental and sociocultural conditions for theover-determination of health-disease outcomes.

Bottom Line: First, a conceptual background of Holopathogenesis is presented as a series of significant interfaces (biomolecular-immunological, physiopathological-clinical, epidemiological-ecosocial).Third, a formalization of intra- and inter-level correspondences, over-determination processes, effects and links of Holopathogenesis models is proposed.Finally, the Holopathogenesis frame is evaluated as a comprehensive theoretical pathology taken as a preliminary step towards a unified theory of health-disease.

View Article: PubMed Central - PubMed

Affiliation: Instituto de Saúde Coletiva, Universidade Federal da Bahia, Salvador, BA, Brasil.

ABSTRACT
This article presents a systematic framework for modeling several classes of illness-sickness-disease named as Holopathogenesis. Holopathogenesis is defined as processes of over-determination of diseases and related conditions taken as a whole, comprising selected facets of the complex object Health. First, a conceptual background of Holopathogenesis is presented as a series of significant interfaces (biomolecular-immunological, physiopathological-clinical, epidemiological-ecosocial). Second, propositions derived from Holopathogenesis are introduced in order to allow drawing the disease-illness-sickness complex as a hierarchical network of networks. Third, a formalization of intra- and inter-level correspondences, over-determination processes, effects and links of Holopathogenesis models is proposed. Finally, the Holopathogenesis frame is evaluated as a comprehensive theoretical pathology taken as a preliminary step towards a unified theory of health-disease.

Show MeSH