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Towards a unified theory of health-disease: II. Holopathogenesis.

Almeida Filho N - Rev Saude Publica (2014)

Bottom Line: First, a conceptual background of Holopathogenesis is presented as a series of significant interfaces (biomolecular-immunological, physiopathological-clinical, epidemiological-ecosocial).Third, a formalization of intra- and inter-level correspondences, over-determination processes, effects and links of Holopathogenesis models is proposed.Finally, the Holopathogenesis frame is evaluated as a comprehensive theoretical pathology taken as a preliminary step towards a unified theory of health-disease.

View Article: PubMed Central - PubMed

Affiliation: Instituto de Saúde Coletiva, Universidade Federal da Bahia, Salvador, BA, Brasil.

ABSTRACT
This article presents a systematic framework for modeling several classes of illness-sickness-disease named as Holopathogenesis. Holopathogenesis is defined as processes of over-determination of diseases and related conditions taken as a whole, comprising selected facets of the complex object Health. First, a conceptual background of Holopathogenesis is presented as a series of significant interfaces (biomolecular-immunological, physiopathological-clinical, epidemiological-ecosocial). Second, propositions derived from Holopathogenesis are introduced in order to allow drawing the disease-illness-sickness complex as a hierarchical network of networks. Third, a formalization of intra- and inter-level correspondences, over-determination processes, effects and links of Holopathogenesis models is proposed. Finally, the Holopathogenesis frame is evaluated as a comprehensive theoretical pathology taken as a preliminary step towards a unified theory of health-disease.

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inter-determination among sub-spaces in the complexDisease-Illness-Sickness.
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Related In: Results  -  Collection

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f05: inter-determination among sub-spaces in the complexDisease-Illness-Sickness.

Mentions: Figure 5 is a graphical representation of thismodel, inter-determined by a complex network of networks composed by anon-hierarchical, interconnected order of dimensions, holopathogens and outcomes.Many of the links internal to the sub-models in the sub-spaces belong to or areconnected to other chains of determination, in different levels or domains. Suchrelations are articulated by ‘structural coupling’, generated by simultaneousprocesses of ‘over-determination’ of the different classes of cDIS.


Towards a unified theory of health-disease: II. Holopathogenesis.

Almeida Filho N - Rev Saude Publica (2014)

inter-determination among sub-spaces in the complexDisease-Illness-Sickness.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4206141&req=5

f05: inter-determination among sub-spaces in the complexDisease-Illness-Sickness.
Mentions: Figure 5 is a graphical representation of thismodel, inter-determined by a complex network of networks composed by anon-hierarchical, interconnected order of dimensions, holopathogens and outcomes.Many of the links internal to the sub-models in the sub-spaces belong to or areconnected to other chains of determination, in different levels or domains. Suchrelations are articulated by ‘structural coupling’, generated by simultaneousprocesses of ‘over-determination’ of the different classes of cDIS.

Bottom Line: First, a conceptual background of Holopathogenesis is presented as a series of significant interfaces (biomolecular-immunological, physiopathological-clinical, epidemiological-ecosocial).Third, a formalization of intra- and inter-level correspondences, over-determination processes, effects and links of Holopathogenesis models is proposed.Finally, the Holopathogenesis frame is evaluated as a comprehensive theoretical pathology taken as a preliminary step towards a unified theory of health-disease.

View Article: PubMed Central - PubMed

Affiliation: Instituto de Saúde Coletiva, Universidade Federal da Bahia, Salvador, BA, Brasil.

ABSTRACT
This article presents a systematic framework for modeling several classes of illness-sickness-disease named as Holopathogenesis. Holopathogenesis is defined as processes of over-determination of diseases and related conditions taken as a whole, comprising selected facets of the complex object Health. First, a conceptual background of Holopathogenesis is presented as a series of significant interfaces (biomolecular-immunological, physiopathological-clinical, epidemiological-ecosocial). Second, propositions derived from Holopathogenesis are introduced in order to allow drawing the disease-illness-sickness complex as a hierarchical network of networks. Third, a formalization of intra- and inter-level correspondences, over-determination processes, effects and links of Holopathogenesis models is proposed. Finally, the Holopathogenesis frame is evaluated as a comprehensive theoretical pathology taken as a preliminary step towards a unified theory of health-disease.

Show MeSH