Limits...
Towards a unified theory of health-disease: II. Holopathogenesis.

Almeida Filho N - Rev Saude Publica (2014)

Bottom Line: First, a conceptual background of Holopathogenesis is presented as a series of significant interfaces (biomolecular-immunological, physiopathological-clinical, epidemiological-ecosocial).Third, a formalization of intra- and inter-level correspondences, over-determination processes, effects and links of Holopathogenesis models is proposed.Finally, the Holopathogenesis frame is evaluated as a comprehensive theoretical pathology taken as a preliminary step towards a unified theory of health-disease.

View Article: PubMed Central - PubMed

Affiliation: Instituto de Saúde Coletiva, Universidade Federal da Bahia, Salvador, BA, Brasil.

ABSTRACT
This article presents a systematic framework for modeling several classes of illness-sickness-disease named as Holopathogenesis. Holopathogenesis is defined as processes of over-determination of diseases and related conditions taken as a whole, comprising selected facets of the complex object Health. First, a conceptual background of Holopathogenesis is presented as a series of significant interfaces (biomolecular-immunological, physiopathological-clinical, epidemiological-ecosocial). Second, propositions derived from Holopathogenesis are introduced in order to allow drawing the disease-illness-sickness complex as a hierarchical network of networks. Third, a formalization of intra- and inter-level correspondences, over-determination processes, effects and links of Holopathogenesis models is proposed. Finally, the Holopathogenesis frame is evaluated as a comprehensive theoretical pathology taken as a preliminary step towards a unified theory of health-disease.

Show MeSH
The complex Disease-Illness-Sickness as a net-network.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4206141&req=5

f04: The complex Disease-Illness-Sickness as a net-network.

Mentions: Assembling knowledge generated by decades of research on the determination of each ofthe pathogenesis submodels, this model is represented in Figure 4 as a network of networks modeling theoverdetermination of depression.


Towards a unified theory of health-disease: II. Holopathogenesis.

Almeida Filho N - Rev Saude Publica (2014)

The complex Disease-Illness-Sickness as a net-network.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4206141&req=5

f04: The complex Disease-Illness-Sickness as a net-network.
Mentions: Assembling knowledge generated by decades of research on the determination of each ofthe pathogenesis submodels, this model is represented in Figure 4 as a network of networks modeling theoverdetermination of depression.

Bottom Line: First, a conceptual background of Holopathogenesis is presented as a series of significant interfaces (biomolecular-immunological, physiopathological-clinical, epidemiological-ecosocial).Third, a formalization of intra- and inter-level correspondences, over-determination processes, effects and links of Holopathogenesis models is proposed.Finally, the Holopathogenesis frame is evaluated as a comprehensive theoretical pathology taken as a preliminary step towards a unified theory of health-disease.

View Article: PubMed Central - PubMed

Affiliation: Instituto de Saúde Coletiva, Universidade Federal da Bahia, Salvador, BA, Brasil.

ABSTRACT
This article presents a systematic framework for modeling several classes of illness-sickness-disease named as Holopathogenesis. Holopathogenesis is defined as processes of over-determination of diseases and related conditions taken as a whole, comprising selected facets of the complex object Health. First, a conceptual background of Holopathogenesis is presented as a series of significant interfaces (biomolecular-immunological, physiopathological-clinical, epidemiological-ecosocial). Second, propositions derived from Holopathogenesis are introduced in order to allow drawing the disease-illness-sickness complex as a hierarchical network of networks. Third, a formalization of intra- and inter-level correspondences, over-determination processes, effects and links of Holopathogenesis models is proposed. Finally, the Holopathogenesis frame is evaluated as a comprehensive theoretical pathology taken as a preliminary step towards a unified theory of health-disease.

Show MeSH