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Towards a unified theory of health-disease: II. Holopathogenesis.

Almeida Filho N - Rev Saude Publica (2014)

Bottom Line: First, a conceptual background of Holopathogenesis is presented as a series of significant interfaces (biomolecular-immunological, physiopathological-clinical, epidemiological-ecosocial).Third, a formalization of intra- and inter-level correspondences, over-determination processes, effects and links of Holopathogenesis models is proposed.Finally, the Holopathogenesis frame is evaluated as a comprehensive theoretical pathology taken as a preliminary step towards a unified theory of health-disease.

View Article: PubMed Central - PubMed

Affiliation: Instituto de Saúde Coletiva, Universidade Federal da Bahia, Salvador, BA, Brasil.

ABSTRACT
This article presents a systematic framework for modeling several classes of illness-sickness-disease named as Holopathogenesis. Holopathogenesis is defined as processes of over-determination of diseases and related conditions taken as a whole, comprising selected facets of the complex object Health. First, a conceptual background of Holopathogenesis is presented as a series of significant interfaces (biomolecular-immunological, physiopathological-clinical, epidemiological-ecosocial). Second, propositions derived from Holopathogenesis are introduced in order to allow drawing the disease-illness-sickness complex as a hierarchical network of networks. Third, a formalization of intra- and inter-level correspondences, over-determination processes, effects and links of Holopathogenesis models is proposed. Finally, the Holopathogenesis frame is evaluated as a comprehensive theoretical pathology taken as a preliminary step towards a unified theory of health-disease.

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The biodemografical and sociocultural hierarchical orders.
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f01: The biodemografical and sociocultural hierarchical orders.

Mentions: Figure 1 presents a visual diagram that allowscomparison between the two hierarchical orders, composed by contiguous planes. Asuperimposition of subindividual levels is evident. However, replacing theindividual organism by the human subject changes the character of eachsupra-individual plane of emergence. For example, given the symbolic significance ofparental links, a family is more than a group of individuals. Although formed bypopulations, considering political aspects of social relations, societies should notbe reduced to mere demographic aggregates. Finally, there is a fundamentalcontradiction between environment and culture, as far as nature is radically andcontinuously transformed by the praxis of the human species.


Towards a unified theory of health-disease: II. Holopathogenesis.

Almeida Filho N - Rev Saude Publica (2014)

The biodemografical and sociocultural hierarchical orders.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4206141&req=5

f01: The biodemografical and sociocultural hierarchical orders.
Mentions: Figure 1 presents a visual diagram that allowscomparison between the two hierarchical orders, composed by contiguous planes. Asuperimposition of subindividual levels is evident. However, replacing theindividual organism by the human subject changes the character of eachsupra-individual plane of emergence. For example, given the symbolic significance ofparental links, a family is more than a group of individuals. Although formed bypopulations, considering political aspects of social relations, societies should notbe reduced to mere demographic aggregates. Finally, there is a fundamentalcontradiction between environment and culture, as far as nature is radically andcontinuously transformed by the praxis of the human species.

Bottom Line: First, a conceptual background of Holopathogenesis is presented as a series of significant interfaces (biomolecular-immunological, physiopathological-clinical, epidemiological-ecosocial).Third, a formalization of intra- and inter-level correspondences, over-determination processes, effects and links of Holopathogenesis models is proposed.Finally, the Holopathogenesis frame is evaluated as a comprehensive theoretical pathology taken as a preliminary step towards a unified theory of health-disease.

View Article: PubMed Central - PubMed

Affiliation: Instituto de Saúde Coletiva, Universidade Federal da Bahia, Salvador, BA, Brasil.

ABSTRACT
This article presents a systematic framework for modeling several classes of illness-sickness-disease named as Holopathogenesis. Holopathogenesis is defined as processes of over-determination of diseases and related conditions taken as a whole, comprising selected facets of the complex object Health. First, a conceptual background of Holopathogenesis is presented as a series of significant interfaces (biomolecular-immunological, physiopathological-clinical, epidemiological-ecosocial). Second, propositions derived from Holopathogenesis are introduced in order to allow drawing the disease-illness-sickness complex as a hierarchical network of networks. Third, a formalization of intra- and inter-level correspondences, over-determination processes, effects and links of Holopathogenesis models is proposed. Finally, the Holopathogenesis frame is evaluated as a comprehensive theoretical pathology taken as a preliminary step towards a unified theory of health-disease.

Show MeSH