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Modulation of interhemispheric functional coordination in electroconvulsive therapy for depression.

Wei Q, Tian Y, Yu Y, Zhang F, Hu X, Dong Y, Chen Y, Hu P, Hu X, Wang K - Transl Psychiatry (2014)

Bottom Line: For depression, electroconvulsive therapy (ECT) is the most rapid and effective therapy, but its underlying mechanism remains unknown.The results showed that, compared with depression patients before ECT, VMHC was significantly increased in superior frontal gyri (BA 8), middle frontal gyri (two clusters: BA 8/9 and BA 10) and angular gyri (BA 39) in depression patients after ECT.Compared with healthy controls, VMHC in those areas was significantly lower in the middle frontal gyri (BA 8/9) and angular gyri (BA 39) in depression patients before ECT, but no significant difference was observed in the superior frontal gyri (BA 8) and middle frontal gyri (BA 10).

View Article: PubMed Central - PubMed

Affiliation: Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.

ABSTRACT
Considerable evidence suggests that depression is related to interhemispheric functional coordination deficits. For depression, electroconvulsive therapy (ECT) is the most rapid and effective therapy, but its underlying mechanism remains unknown. The aim of this study was to explore the impact of ECT on the interhemispheric functional coordination in depression patients. We used resting-state functional magnetic resonance imaging to observe the change of interhemispheric functional coordination with the method of voxel-mirrored homotopic connectivity (VMHC) in 11 depressed patients before and after ECT, compared with 15 healthy controls. The results showed that, compared with depression patients before ECT, VMHC was significantly increased in superior frontal gyri (BA 8), middle frontal gyri (two clusters: BA 8/9 and BA 10) and angular gyri (BA 39) in depression patients after ECT. Compared with healthy controls, VMHC in those areas was significantly lower in the middle frontal gyri (BA 8/9) and angular gyri (BA 39) in depression patients before ECT, but no significant difference was observed in the superior frontal gyri (BA 8) and middle frontal gyri (BA 10). There was no significant correlation between the changes of Hamilton Depression Rating Scale scores and changed VMHC values in those four areas in depression patients. The results suggest that ECT selectively modulated interhemispheric functional coordination in depression patients. Such may play an important mechanistic role in the treatment of depression, and may afford a useful avenue for optimizing treatment.

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The voxel-mirrored homotopic connectivity (VMHC) value of superior frontal gyri (BA 8), middle frontal gyri (two clusters: BA 8/9 and BA 10) and angular gyri (BA 39) in the three groups (healthy controls, patients before and after electroconvulsive therapy (ECT)). HC, healthy controls; Pre, depression patients before ECT; Post, depression patients after ECT. *There is a significant difference between the corresponding group and healthy controls (P<0.05). (a) Compared with healthy controls, VMHC of the superior frontal gyri (BA 8) was significantly higher in depression patients after ECT (t=2.292; P=0.031), but no significant difference was observed between healthy controls and depression patients before ECT (t=−0.540; P=0.594). (b) Compared with healthy controls, VMHC of the middle frontal gyri (BA 8/9) was significantly lower in depression patients before ECT (t=−2.286; P=0.031), but no significant difference was observed between healthy controls and depression patients after ECT (t=1.156; P=0.265). (c) Compared with healthy controls, VMHC of the middle frontal gyri (BA 10) was significantly higher in depression patients after ECT (t=2.549; P=0.018), but no significant difference was observed between healthy controls and depression patients before ECT (t=−1.650; P=0.112). (d) Compared with healthy controls, VMHC of the angular gyri (BA 39) was significantly lower in depression patients before ECT (t=2.632; P=0.015). No significant difference was observed between healthy controls and depression patients after ECT (t=1.740; P=0.095).
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fig2: The voxel-mirrored homotopic connectivity (VMHC) value of superior frontal gyri (BA 8), middle frontal gyri (two clusters: BA 8/9 and BA 10) and angular gyri (BA 39) in the three groups (healthy controls, patients before and after electroconvulsive therapy (ECT)). HC, healthy controls; Pre, depression patients before ECT; Post, depression patients after ECT. *There is a significant difference between the corresponding group and healthy controls (P<0.05). (a) Compared with healthy controls, VMHC of the superior frontal gyri (BA 8) was significantly higher in depression patients after ECT (t=2.292; P=0.031), but no significant difference was observed between healthy controls and depression patients before ECT (t=−0.540; P=0.594). (b) Compared with healthy controls, VMHC of the middle frontal gyri (BA 8/9) was significantly lower in depression patients before ECT (t=−2.286; P=0.031), but no significant difference was observed between healthy controls and depression patients after ECT (t=1.156; P=0.265). (c) Compared with healthy controls, VMHC of the middle frontal gyri (BA 10) was significantly higher in depression patients after ECT (t=2.549; P=0.018), but no significant difference was observed between healthy controls and depression patients before ECT (t=−1.650; P=0.112). (d) Compared with healthy controls, VMHC of the angular gyri (BA 39) was significantly lower in depression patients before ECT (t=2.632; P=0.015). No significant difference was observed between healthy controls and depression patients after ECT (t=1.740; P=0.095).

Mentions: As stated above, we found the VMHC increased in four symmetrical clusters, but we did not know the VMHC of these clusters in health controls and the comparison with patients before and after ECT. So we saved the changed clusters (superior frontal gyri, middle frontal gyri and angular gyri) as a mask, and the VMHC data of the these clusters were extracted and compared (healthy controls vs patients before ECT and healthy controls vs patients after ECT). Compared with healthy controls, VMHC was significantly lower in the middle frontal gyri (BA 8/9) (t=−2.286; P=0.031) and the angular gyri (BA 39) (t=2.632; P=0.015) in patients before ECT, but no significant difference was observed in the superior frontal gyri (BA 8) (t=−0.540; P=0.594) and the middle frontal gyri (BA 10) (t=−1.650; P=0.112). VMHC in patients after ECT was significantly higher than in healthy controls in the superior frontal gyri (BA 8) (t=2.292; P=0.031) and middle frontal gyri (BA 10) (t=2.549; P=0.018). There was no significant difference in the middle frontal gyri (BA 8/9) (t=1.156; P=0.265) and angular gyri (BA 39) (t=1.740; P=0.095) between healthy controls and patients after ECT. Figure 2 shows these outcomes.


Modulation of interhemispheric functional coordination in electroconvulsive therapy for depression.

Wei Q, Tian Y, Yu Y, Zhang F, Hu X, Dong Y, Chen Y, Hu P, Hu X, Wang K - Transl Psychiatry (2014)

The voxel-mirrored homotopic connectivity (VMHC) value of superior frontal gyri (BA 8), middle frontal gyri (two clusters: BA 8/9 and BA 10) and angular gyri (BA 39) in the three groups (healthy controls, patients before and after electroconvulsive therapy (ECT)). HC, healthy controls; Pre, depression patients before ECT; Post, depression patients after ECT. *There is a significant difference between the corresponding group and healthy controls (P<0.05). (a) Compared with healthy controls, VMHC of the superior frontal gyri (BA 8) was significantly higher in depression patients after ECT (t=2.292; P=0.031), but no significant difference was observed between healthy controls and depression patients before ECT (t=−0.540; P=0.594). (b) Compared with healthy controls, VMHC of the middle frontal gyri (BA 8/9) was significantly lower in depression patients before ECT (t=−2.286; P=0.031), but no significant difference was observed between healthy controls and depression patients after ECT (t=1.156; P=0.265). (c) Compared with healthy controls, VMHC of the middle frontal gyri (BA 10) was significantly higher in depression patients after ECT (t=2.549; P=0.018), but no significant difference was observed between healthy controls and depression patients before ECT (t=−1.650; P=0.112). (d) Compared with healthy controls, VMHC of the angular gyri (BA 39) was significantly lower in depression patients before ECT (t=2.632; P=0.015). No significant difference was observed between healthy controls and depression patients after ECT (t=1.740; P=0.095).
© Copyright Policy - open-access
Related In: Results  -  Collection

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Show All Figures
getmorefigures.php?uid=PMC4202999&req=5

fig2: The voxel-mirrored homotopic connectivity (VMHC) value of superior frontal gyri (BA 8), middle frontal gyri (two clusters: BA 8/9 and BA 10) and angular gyri (BA 39) in the three groups (healthy controls, patients before and after electroconvulsive therapy (ECT)). HC, healthy controls; Pre, depression patients before ECT; Post, depression patients after ECT. *There is a significant difference between the corresponding group and healthy controls (P<0.05). (a) Compared with healthy controls, VMHC of the superior frontal gyri (BA 8) was significantly higher in depression patients after ECT (t=2.292; P=0.031), but no significant difference was observed between healthy controls and depression patients before ECT (t=−0.540; P=0.594). (b) Compared with healthy controls, VMHC of the middle frontal gyri (BA 8/9) was significantly lower in depression patients before ECT (t=−2.286; P=0.031), but no significant difference was observed between healthy controls and depression patients after ECT (t=1.156; P=0.265). (c) Compared with healthy controls, VMHC of the middle frontal gyri (BA 10) was significantly higher in depression patients after ECT (t=2.549; P=0.018), but no significant difference was observed between healthy controls and depression patients before ECT (t=−1.650; P=0.112). (d) Compared with healthy controls, VMHC of the angular gyri (BA 39) was significantly lower in depression patients before ECT (t=2.632; P=0.015). No significant difference was observed between healthy controls and depression patients after ECT (t=1.740; P=0.095).
Mentions: As stated above, we found the VMHC increased in four symmetrical clusters, but we did not know the VMHC of these clusters in health controls and the comparison with patients before and after ECT. So we saved the changed clusters (superior frontal gyri, middle frontal gyri and angular gyri) as a mask, and the VMHC data of the these clusters were extracted and compared (healthy controls vs patients before ECT and healthy controls vs patients after ECT). Compared with healthy controls, VMHC was significantly lower in the middle frontal gyri (BA 8/9) (t=−2.286; P=0.031) and the angular gyri (BA 39) (t=2.632; P=0.015) in patients before ECT, but no significant difference was observed in the superior frontal gyri (BA 8) (t=−0.540; P=0.594) and the middle frontal gyri (BA 10) (t=−1.650; P=0.112). VMHC in patients after ECT was significantly higher than in healthy controls in the superior frontal gyri (BA 8) (t=2.292; P=0.031) and middle frontal gyri (BA 10) (t=2.549; P=0.018). There was no significant difference in the middle frontal gyri (BA 8/9) (t=1.156; P=0.265) and angular gyri (BA 39) (t=1.740; P=0.095) between healthy controls and patients after ECT. Figure 2 shows these outcomes.

Bottom Line: For depression, electroconvulsive therapy (ECT) is the most rapid and effective therapy, but its underlying mechanism remains unknown.The results showed that, compared with depression patients before ECT, VMHC was significantly increased in superior frontal gyri (BA 8), middle frontal gyri (two clusters: BA 8/9 and BA 10) and angular gyri (BA 39) in depression patients after ECT.Compared with healthy controls, VMHC in those areas was significantly lower in the middle frontal gyri (BA 8/9) and angular gyri (BA 39) in depression patients before ECT, but no significant difference was observed in the superior frontal gyri (BA 8) and middle frontal gyri (BA 10).

View Article: PubMed Central - PubMed

Affiliation: Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.

ABSTRACT
Considerable evidence suggests that depression is related to interhemispheric functional coordination deficits. For depression, electroconvulsive therapy (ECT) is the most rapid and effective therapy, but its underlying mechanism remains unknown. The aim of this study was to explore the impact of ECT on the interhemispheric functional coordination in depression patients. We used resting-state functional magnetic resonance imaging to observe the change of interhemispheric functional coordination with the method of voxel-mirrored homotopic connectivity (VMHC) in 11 depressed patients before and after ECT, compared with 15 healthy controls. The results showed that, compared with depression patients before ECT, VMHC was significantly increased in superior frontal gyri (BA 8), middle frontal gyri (two clusters: BA 8/9 and BA 10) and angular gyri (BA 39) in depression patients after ECT. Compared with healthy controls, VMHC in those areas was significantly lower in the middle frontal gyri (BA 8/9) and angular gyri (BA 39) in depression patients before ECT, but no significant difference was observed in the superior frontal gyri (BA 8) and middle frontal gyri (BA 10). There was no significant correlation between the changes of Hamilton Depression Rating Scale scores and changed VMHC values in those four areas in depression patients. The results suggest that ECT selectively modulated interhemispheric functional coordination in depression patients. Such may play an important mechanistic role in the treatment of depression, and may afford a useful avenue for optimizing treatment.

Show MeSH
Related in: MedlinePlus