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Modulation of interhemispheric functional coordination in electroconvulsive therapy for depression.

Wei Q, Tian Y, Yu Y, Zhang F, Hu X, Dong Y, Chen Y, Hu P, Hu X, Wang K - Transl Psychiatry (2014)

Bottom Line: For depression, electroconvulsive therapy (ECT) is the most rapid and effective therapy, but its underlying mechanism remains unknown.The results showed that, compared with depression patients before ECT, VMHC was significantly increased in superior frontal gyri (BA 8), middle frontal gyri (two clusters: BA 8/9 and BA 10) and angular gyri (BA 39) in depression patients after ECT.Compared with healthy controls, VMHC in those areas was significantly lower in the middle frontal gyri (BA 8/9) and angular gyri (BA 39) in depression patients before ECT, but no significant difference was observed in the superior frontal gyri (BA 8) and middle frontal gyri (BA 10).

View Article: PubMed Central - PubMed

Affiliation: Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.

ABSTRACT
Considerable evidence suggests that depression is related to interhemispheric functional coordination deficits. For depression, electroconvulsive therapy (ECT) is the most rapid and effective therapy, but its underlying mechanism remains unknown. The aim of this study was to explore the impact of ECT on the interhemispheric functional coordination in depression patients. We used resting-state functional magnetic resonance imaging to observe the change of interhemispheric functional coordination with the method of voxel-mirrored homotopic connectivity (VMHC) in 11 depressed patients before and after ECT, compared with 15 healthy controls. The results showed that, compared with depression patients before ECT, VMHC was significantly increased in superior frontal gyri (BA 8), middle frontal gyri (two clusters: BA 8/9 and BA 10) and angular gyri (BA 39) in depression patients after ECT. Compared with healthy controls, VMHC in those areas was significantly lower in the middle frontal gyri (BA 8/9) and angular gyri (BA 39) in depression patients before ECT, but no significant difference was observed in the superior frontal gyri (BA 8) and middle frontal gyri (BA 10). There was no significant correlation between the changes of Hamilton Depression Rating Scale scores and changed VMHC values in those four areas in depression patients. The results suggest that ECT selectively modulated interhemispheric functional coordination in depression patients. Such may play an important mechanistic role in the treatment of depression, and may afford a useful avenue for optimizing treatment.

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Related in: MedlinePlus

Statistical maps of voxel t-values of voxel-mirrored homotopic connectivity comparisons of depression patients before and after electroconvulsive therapy. The numbers at the top left of images refer to the z-coordinates in Montreal Neurological Institute space. The threshold has been set at a corrected P<0.05 (corrected with P<0.01 for each voxel and a cluster volume ⩾32 voxels) and the t-score bar is shown at the right of the map. The left side of the each image corresponds to the right hemisphere of the brain and vice versa.
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fig1: Statistical maps of voxel t-values of voxel-mirrored homotopic connectivity comparisons of depression patients before and after electroconvulsive therapy. The numbers at the top left of images refer to the z-coordinates in Montreal Neurological Institute space. The threshold has been set at a corrected P<0.05 (corrected with P<0.01 for each voxel and a cluster volume ⩾32 voxels) and the t-score bar is shown at the right of the map. The left side of the each image corresponds to the right hemisphere of the brain and vice versa.

Mentions: To identify potentially significant changes in VMHC between depression patients before and after ECT, the analysis of gray matter was performed correcting thresholds by the Monte–Carlo simulation with the Alphasim program in AFNI (P<0.05, corrected with P<0.01 for each voxel and a cluster volume ⩾32 voxels). As shown in Table 1 and Figure 1, VMHC was significantly increased in superior frontal gyri (BA 8), middle frontal gyri (two clusters: BA 8/9 and BA 10) and angular gyri (BA 39) in patients after ECT, compared with patients before ECT.


Modulation of interhemispheric functional coordination in electroconvulsive therapy for depression.

Wei Q, Tian Y, Yu Y, Zhang F, Hu X, Dong Y, Chen Y, Hu P, Hu X, Wang K - Transl Psychiatry (2014)

Statistical maps of voxel t-values of voxel-mirrored homotopic connectivity comparisons of depression patients before and after electroconvulsive therapy. The numbers at the top left of images refer to the z-coordinates in Montreal Neurological Institute space. The threshold has been set at a corrected P<0.05 (corrected with P<0.01 for each voxel and a cluster volume ⩾32 voxels) and the t-score bar is shown at the right of the map. The left side of the each image corresponds to the right hemisphere of the brain and vice versa.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4202999&req=5

fig1: Statistical maps of voxel t-values of voxel-mirrored homotopic connectivity comparisons of depression patients before and after electroconvulsive therapy. The numbers at the top left of images refer to the z-coordinates in Montreal Neurological Institute space. The threshold has been set at a corrected P<0.05 (corrected with P<0.01 for each voxel and a cluster volume ⩾32 voxels) and the t-score bar is shown at the right of the map. The left side of the each image corresponds to the right hemisphere of the brain and vice versa.
Mentions: To identify potentially significant changes in VMHC between depression patients before and after ECT, the analysis of gray matter was performed correcting thresholds by the Monte–Carlo simulation with the Alphasim program in AFNI (P<0.05, corrected with P<0.01 for each voxel and a cluster volume ⩾32 voxels). As shown in Table 1 and Figure 1, VMHC was significantly increased in superior frontal gyri (BA 8), middle frontal gyri (two clusters: BA 8/9 and BA 10) and angular gyri (BA 39) in patients after ECT, compared with patients before ECT.

Bottom Line: For depression, electroconvulsive therapy (ECT) is the most rapid and effective therapy, but its underlying mechanism remains unknown.The results showed that, compared with depression patients before ECT, VMHC was significantly increased in superior frontal gyri (BA 8), middle frontal gyri (two clusters: BA 8/9 and BA 10) and angular gyri (BA 39) in depression patients after ECT.Compared with healthy controls, VMHC in those areas was significantly lower in the middle frontal gyri (BA 8/9) and angular gyri (BA 39) in depression patients before ECT, but no significant difference was observed in the superior frontal gyri (BA 8) and middle frontal gyri (BA 10).

View Article: PubMed Central - PubMed

Affiliation: Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.

ABSTRACT
Considerable evidence suggests that depression is related to interhemispheric functional coordination deficits. For depression, electroconvulsive therapy (ECT) is the most rapid and effective therapy, but its underlying mechanism remains unknown. The aim of this study was to explore the impact of ECT on the interhemispheric functional coordination in depression patients. We used resting-state functional magnetic resonance imaging to observe the change of interhemispheric functional coordination with the method of voxel-mirrored homotopic connectivity (VMHC) in 11 depressed patients before and after ECT, compared with 15 healthy controls. The results showed that, compared with depression patients before ECT, VMHC was significantly increased in superior frontal gyri (BA 8), middle frontal gyri (two clusters: BA 8/9 and BA 10) and angular gyri (BA 39) in depression patients after ECT. Compared with healthy controls, VMHC in those areas was significantly lower in the middle frontal gyri (BA 8/9) and angular gyri (BA 39) in depression patients before ECT, but no significant difference was observed in the superior frontal gyri (BA 8) and middle frontal gyri (BA 10). There was no significant correlation between the changes of Hamilton Depression Rating Scale scores and changed VMHC values in those four areas in depression patients. The results suggest that ECT selectively modulated interhemispheric functional coordination in depression patients. Such may play an important mechanistic role in the treatment of depression, and may afford a useful avenue for optimizing treatment.

Show MeSH
Related in: MedlinePlus