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A vinyl chloride-exposed worker with an adrenal gland angiosarcoma: a case report.

Criscuolo M, Valerio J, Gianicolo ME, Gianicolo EA, Portaluri M - Ind Health (2013)

Bottom Line: The bibliographic data was found on the PUBMED bibliographic search site after entering the word "extrahepaticangiosarcoma".Extra-hepatic angiosarcomas have been reported in VC workers, but never AEA.This is the first published report of AEA diagnosed in a worker exposed to VC.

View Article: PubMed Central - PubMed

Affiliation: Pathology Department, "Perrino" Hospital, Italy.

ABSTRACT
Adrenal epithelioidangiosarcoma (AEA) is a rare neoplasm that accounts for less than 1% of sarcomas. Due to its rarity, it can easily be misdiagnosed, both by the clinician and the pathologist. Data on the patient's occupational history was collected and analyzed. The bibliographic data was found on the PUBMED bibliographic search site after entering the word "extrahepaticangiosarcoma". We report a case of adrenal epithelioidangiosarcoma (AEA) in a 68 yr-old Caucasian male factory worker exposed to Vinyl Chloride (VC) for 15 yr. He underwent surgery, chemotherapy and radiotherapy. Hepatic angiosarcoma is a known consequence of VC exposure, but occupational causality of extra-hepatic angiosarcoma is controversial. Extra-hepatic angiosarcomas have been reported in VC workers, but never AEA. Cancerogenic effects of VC involve all endothelial areas of the body and extra-hepatic endothelial tumors may also be caused by this substance. This is the first published report of AEA diagnosed in a worker exposed to VC.

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Related in: MedlinePlus

Immunohistochemical staining for CD31 antigen. Note intense brown coloration of themembrane of the endothelial neoplastic cells with residual negative adrenal tissue(×40).
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fig_003: Immunohistochemical staining for CD31 antigen. Note intense brown coloration of themembrane of the endothelial neoplastic cells with residual negative adrenal tissue(×40).

Mentions: Clear cells as hyperplastic adrenal tissue (bottom) and neoplastic vascular channels(top) with malignant endothelial epithelioid cells (hematoxylin-eosin ×32).


A vinyl chloride-exposed worker with an adrenal gland angiosarcoma: a case report.

Criscuolo M, Valerio J, Gianicolo ME, Gianicolo EA, Portaluri M - Ind Health (2013)

Immunohistochemical staining for CD31 antigen. Note intense brown coloration of themembrane of the endothelial neoplastic cells with residual negative adrenal tissue(×40).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4202765&req=5

fig_003: Immunohistochemical staining for CD31 antigen. Note intense brown coloration of themembrane of the endothelial neoplastic cells with residual negative adrenal tissue(×40).
Mentions: Clear cells as hyperplastic adrenal tissue (bottom) and neoplastic vascular channels(top) with malignant endothelial epithelioid cells (hematoxylin-eosin ×32).

Bottom Line: The bibliographic data was found on the PUBMED bibliographic search site after entering the word "extrahepaticangiosarcoma".Extra-hepatic angiosarcomas have been reported in VC workers, but never AEA.This is the first published report of AEA diagnosed in a worker exposed to VC.

View Article: PubMed Central - PubMed

Affiliation: Pathology Department, "Perrino" Hospital, Italy.

ABSTRACT
Adrenal epithelioidangiosarcoma (AEA) is a rare neoplasm that accounts for less than 1% of sarcomas. Due to its rarity, it can easily be misdiagnosed, both by the clinician and the pathologist. Data on the patient's occupational history was collected and analyzed. The bibliographic data was found on the PUBMED bibliographic search site after entering the word "extrahepaticangiosarcoma". We report a case of adrenal epithelioidangiosarcoma (AEA) in a 68 yr-old Caucasian male factory worker exposed to Vinyl Chloride (VC) for 15 yr. He underwent surgery, chemotherapy and radiotherapy. Hepatic angiosarcoma is a known consequence of VC exposure, but occupational causality of extra-hepatic angiosarcoma is controversial. Extra-hepatic angiosarcomas have been reported in VC workers, but never AEA. Cancerogenic effects of VC involve all endothelial areas of the body and extra-hepatic endothelial tumors may also be caused by this substance. This is the first published report of AEA diagnosed in a worker exposed to VC.

Show MeSH
Related in: MedlinePlus