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Serum levels of TGF-β1 and MCP-1 as biomarkers for progressive coal workers' pneumoconiosis in retired coal workers: a three-year follow-up study.

Lee JS, Shin JH, Lee KM, Hwang JH, Baek JE, Kim JH, Choi BS - Ind Health (2014)

Bottom Line: Various cytokines activated by the inhalation of coal dust may mediate inflammation and lead to tissue damage.Median levels of TGF-β1 and MCP-1 were significantly higher in subjects with progressive CWP than in those without CWP progression.The results suggest that high serum levels of TGF-β1 and MCP-1 are associated with the progression of CWP.

View Article: PubMed Central - PubMed

Affiliation: Occupational Lung Diseases Institute, Korea Workers' Compensation and Welfare Service, Republic of Korea.

ABSTRACT
Various cytokines activated by the inhalation of coal dust may mediate inflammation and lead to tissue damage. Objective of this study was to examine the relationships between coal workers' pneumoconiosis (CWP) progression over a 3 yr period and the serum levels of cytokines in 85 retired coal workers. To investigate the relevance of serum cytokines in CWP, serum levels of interleukin-8 (IL-8), tumor necrosis factor-alpha (TNF-α), transforming growth factor-beta1 (TGF-β1), and monocyte chemotactic protein-1 (MCP-1) as progressive CWP biomarkers were studied in relation to the progression of pneumoconiosis over a 3 yr period in 85 patients with CWP. CWP progression was evaluated through paired comparisons of chest radiographs. Median levels of TGF-β1 and MCP-1 were significantly higher in subjects with progressive CWP than in those without CWP progression. The area under the ROC curve for TGF-β1 (0.693) and MCP-1 (0.653) indicated that these cytokines could serve as biomarkers for the progression of CWP. Serum TGF-β1 levels were related to the progression of CWP (β=0.247, p=0.016). The results suggest that high serum levels of TGF-β1 and MCP-1 are associated with the progression of CWP.

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Related in: MedlinePlus

ROC curve for TGF-β1 and MCP-1 according to progression of CWP (n=85). The areasunder the ROC curve for TGF-β1 and MCP-1 were 0.69 (95% CI, 0.55–0.84,p=0.012) and 0.65 (95% CI, 0.50–0.81,p=0.048), respectively. The optimal cutoff values ofTGFβ1 and MCP1 for the progression of pneumoconiosis were 79.2 ng/ml (sensitivity andspecificity of 61.1% and 61.2%) and 34.3 pg/ml (sensitivity and specificity of 66.7%and 67.2%), respectively.
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fig_001: ROC curve for TGF-β1 and MCP-1 according to progression of CWP (n=85). The areasunder the ROC curve for TGF-β1 and MCP-1 were 0.69 (95% CI, 0.55–0.84,p=0.012) and 0.65 (95% CI, 0.50–0.81,p=0.048), respectively. The optimal cutoff values ofTGFβ1 and MCP1 for the progression of pneumoconiosis were 79.2 ng/ml (sensitivity andspecificity of 61.1% and 61.2%) and 34.3 pg/ml (sensitivity and specificity of 66.7%and 67.2%), respectively.

Mentions: AUROC, area under the ROC curve; SE, standard error; CWP, coal workers’pneumoconiosis; 95% CI, 95% confidence interval a In all subjects (n=85).


Serum levels of TGF-β1 and MCP-1 as biomarkers for progressive coal workers' pneumoconiosis in retired coal workers: a three-year follow-up study.

Lee JS, Shin JH, Lee KM, Hwang JH, Baek JE, Kim JH, Choi BS - Ind Health (2014)

ROC curve for TGF-β1 and MCP-1 according to progression of CWP (n=85). The areasunder the ROC curve for TGF-β1 and MCP-1 were 0.69 (95% CI, 0.55–0.84,p=0.012) and 0.65 (95% CI, 0.50–0.81,p=0.048), respectively. The optimal cutoff values ofTGFβ1 and MCP1 for the progression of pneumoconiosis were 79.2 ng/ml (sensitivity andspecificity of 61.1% and 61.2%) and 34.3 pg/ml (sensitivity and specificity of 66.7%and 67.2%), respectively.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4202754&req=5

fig_001: ROC curve for TGF-β1 and MCP-1 according to progression of CWP (n=85). The areasunder the ROC curve for TGF-β1 and MCP-1 were 0.69 (95% CI, 0.55–0.84,p=0.012) and 0.65 (95% CI, 0.50–0.81,p=0.048), respectively. The optimal cutoff values ofTGFβ1 and MCP1 for the progression of pneumoconiosis were 79.2 ng/ml (sensitivity andspecificity of 61.1% and 61.2%) and 34.3 pg/ml (sensitivity and specificity of 66.7%and 67.2%), respectively.
Mentions: AUROC, area under the ROC curve; SE, standard error; CWP, coal workers’pneumoconiosis; 95% CI, 95% confidence interval a In all subjects (n=85).

Bottom Line: Various cytokines activated by the inhalation of coal dust may mediate inflammation and lead to tissue damage.Median levels of TGF-β1 and MCP-1 were significantly higher in subjects with progressive CWP than in those without CWP progression.The results suggest that high serum levels of TGF-β1 and MCP-1 are associated with the progression of CWP.

View Article: PubMed Central - PubMed

Affiliation: Occupational Lung Diseases Institute, Korea Workers' Compensation and Welfare Service, Republic of Korea.

ABSTRACT
Various cytokines activated by the inhalation of coal dust may mediate inflammation and lead to tissue damage. Objective of this study was to examine the relationships between coal workers' pneumoconiosis (CWP) progression over a 3 yr period and the serum levels of cytokines in 85 retired coal workers. To investigate the relevance of serum cytokines in CWP, serum levels of interleukin-8 (IL-8), tumor necrosis factor-alpha (TNF-α), transforming growth factor-beta1 (TGF-β1), and monocyte chemotactic protein-1 (MCP-1) as progressive CWP biomarkers were studied in relation to the progression of pneumoconiosis over a 3 yr period in 85 patients with CWP. CWP progression was evaluated through paired comparisons of chest radiographs. Median levels of TGF-β1 and MCP-1 were significantly higher in subjects with progressive CWP than in those without CWP progression. The area under the ROC curve for TGF-β1 (0.693) and MCP-1 (0.653) indicated that these cytokines could serve as biomarkers for the progression of CWP. Serum TGF-β1 levels were related to the progression of CWP (β=0.247, p=0.016). The results suggest that high serum levels of TGF-β1 and MCP-1 are associated with the progression of CWP.

Show MeSH
Related in: MedlinePlus