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The effects of impact vibration on peripheral blood vessels and nerves.

Krajnak KM, Waugh S, Johnson C, Miller GR, Xu X, Warren C, Dong RG - Ind Health (2013)

Bottom Line: Responsiveness of the ventral tail artery to adrenoreceptor-mediated vasoconstriction and acetylcholine-mediated re-dilation was measured ex vivo.Ventral tail nerves and nerve endings in the skin were assessed using morphological and immunohistochemical techniques.Impact vibration did not alter vascular responsiveness to any factors or affect trunk nerves.

View Article: PubMed Central - PubMed

Affiliation: Engineering and Controls Technology Branch, National Institutes for Occupational Safety and Health, USA.

ABSTRACT
Research regarding the risk of developing hand-arm vibration syndrome after exposure to impact vibration has produced conflicting results. This study used an established animal model of vibration-induced dysfunction to determine how exposure to impact vibration affects peripheral blood vessels and nerves. The tails of male rats were exposed to a single bout of impact vibration (15 min exposure, at a dominant frequency of 30 Hz and an unweighted acceleration of approximately 345 m/s(2)) generated by a riveting hammer. Responsiveness of the ventral tail artery to adrenoreceptor-mediated vasoconstriction and acetylcholine-mediated re-dilation was measured ex vivo. Ventral tail nerves and nerve endings in the skin were assessed using morphological and immunohistochemical techniques. Impact vibration did not alter vascular responsiveness to any factors or affect trunk nerves. However, 4 days following exposure there was an increase in protein-gene product (PGP) 9.5 staining around hair follicles. A single exposure to impact vibration, with the exposure characteristics described above, affects peripheral nerves but not blood vessels.

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Related in: MedlinePlus

Representative photomicrographs of PGP9.5 immunostaining in the tail skin fromcontrol and impact exposed rats (A; bar=100 µm). The box in the control photo isrepresentative of the box used to collect staining measures under the dermis and thebox in the impact photo is representative of the box used to collect staining measuresaround hair follicles. The percent area labeled with PGP 9.5 was greater inimpact-exposed than control rats around the hair follicles (B; *p<0.05), but notunder the dermis (C). Exposure to impact did not alter the percent area labeled Ox6around the hair follicles (D).
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fig_005: Representative photomicrographs of PGP9.5 immunostaining in the tail skin fromcontrol and impact exposed rats (A; bar=100 µm). The box in the control photo isrepresentative of the box used to collect staining measures under the dermis and thebox in the impact photo is representative of the box used to collect staining measuresaround hair follicles. The percent area labeled with PGP 9.5 was greater inimpact-exposed than control rats around the hair follicles (B; *p<0.05), but notunder the dermis (C). Exposure to impact did not alter the percent area labeled Ox6around the hair follicles (D).

Mentions: The photomicrographs in Fig. 5AFig. 5.


The effects of impact vibration on peripheral blood vessels and nerves.

Krajnak KM, Waugh S, Johnson C, Miller GR, Xu X, Warren C, Dong RG - Ind Health (2013)

Representative photomicrographs of PGP9.5 immunostaining in the tail skin fromcontrol and impact exposed rats (A; bar=100 µm). The box in the control photo isrepresentative of the box used to collect staining measures under the dermis and thebox in the impact photo is representative of the box used to collect staining measuresaround hair follicles. The percent area labeled with PGP 9.5 was greater inimpact-exposed than control rats around the hair follicles (B; *p<0.05), but notunder the dermis (C). Exposure to impact did not alter the percent area labeled Ox6around the hair follicles (D).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4202742&req=5

fig_005: Representative photomicrographs of PGP9.5 immunostaining in the tail skin fromcontrol and impact exposed rats (A; bar=100 µm). The box in the control photo isrepresentative of the box used to collect staining measures under the dermis and thebox in the impact photo is representative of the box used to collect staining measuresaround hair follicles. The percent area labeled with PGP 9.5 was greater inimpact-exposed than control rats around the hair follicles (B; *p<0.05), but notunder the dermis (C). Exposure to impact did not alter the percent area labeled Ox6around the hair follicles (D).
Mentions: The photomicrographs in Fig. 5AFig. 5.

Bottom Line: Responsiveness of the ventral tail artery to adrenoreceptor-mediated vasoconstriction and acetylcholine-mediated re-dilation was measured ex vivo.Ventral tail nerves and nerve endings in the skin were assessed using morphological and immunohistochemical techniques.Impact vibration did not alter vascular responsiveness to any factors or affect trunk nerves.

View Article: PubMed Central - PubMed

Affiliation: Engineering and Controls Technology Branch, National Institutes for Occupational Safety and Health, USA.

ABSTRACT
Research regarding the risk of developing hand-arm vibration syndrome after exposure to impact vibration has produced conflicting results. This study used an established animal model of vibration-induced dysfunction to determine how exposure to impact vibration affects peripheral blood vessels and nerves. The tails of male rats were exposed to a single bout of impact vibration (15 min exposure, at a dominant frequency of 30 Hz and an unweighted acceleration of approximately 345 m/s(2)) generated by a riveting hammer. Responsiveness of the ventral tail artery to adrenoreceptor-mediated vasoconstriction and acetylcholine-mediated re-dilation was measured ex vivo. Ventral tail nerves and nerve endings in the skin were assessed using morphological and immunohistochemical techniques. Impact vibration did not alter vascular responsiveness to any factors or affect trunk nerves. However, 4 days following exposure there was an increase in protein-gene product (PGP) 9.5 staining around hair follicles. A single exposure to impact vibration, with the exposure characteristics described above, affects peripheral nerves but not blood vessels.

Show MeSH
Related in: MedlinePlus