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The effects of impact vibration on peripheral blood vessels and nerves.

Krajnak KM, Waugh S, Johnson C, Miller GR, Xu X, Warren C, Dong RG - Ind Health (2013)

Bottom Line: Responsiveness of the ventral tail artery to adrenoreceptor-mediated vasoconstriction and acetylcholine-mediated re-dilation was measured ex vivo.Ventral tail nerves and nerve endings in the skin were assessed using morphological and immunohistochemical techniques.Impact vibration did not alter vascular responsiveness to any factors or affect trunk nerves.

View Article: PubMed Central - PubMed

Affiliation: Engineering and Controls Technology Branch, National Institutes for Occupational Safety and Health, USA.

ABSTRACT
Research regarding the risk of developing hand-arm vibration syndrome after exposure to impact vibration has produced conflicting results. This study used an established animal model of vibration-induced dysfunction to determine how exposure to impact vibration affects peripheral blood vessels and nerves. The tails of male rats were exposed to a single bout of impact vibration (15 min exposure, at a dominant frequency of 30 Hz and an unweighted acceleration of approximately 345 m/s(2)) generated by a riveting hammer. Responsiveness of the ventral tail artery to adrenoreceptor-mediated vasoconstriction and acetylcholine-mediated re-dilation was measured ex vivo. Ventral tail nerves and nerve endings in the skin were assessed using morphological and immunohistochemical techniques. Impact vibration did not alter vascular responsiveness to any factors or affect trunk nerves. However, 4 days following exposure there was an increase in protein-gene product (PGP) 9.5 staining around hair follicles. A single exposure to impact vibration, with the exposure characteristics described above, affects peripheral nerves but not blood vessels.

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Related in: MedlinePlus

Dose-dependent vasoconstriction of the ventral tail artery in response to the α1- andα2C-adrenoreceptor agonists phenylephrine (A) and UK14304 (B) was not affected byexposure to impact vibration or noise from the riveting gun. Acetylcholine-inducedredilation (C) also was not altered by these exposures. Data are expressed as meanchanges (i.e.,% constriction from baseline or % redilation from constricted baseline ±SEM).
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fig_002: Dose-dependent vasoconstriction of the ventral tail artery in response to the α1- andα2C-adrenoreceptor agonists phenylephrine (A) and UK14304 (B) was not affected byexposure to impact vibration or noise from the riveting gun. Acetylcholine-inducedredilation (C) also was not altered by these exposures. Data are expressed as meanchanges (i.e.,% constriction from baseline or % redilation from constricted baseline ±SEM).

Mentions: Exposure to impact vibration or the noise of the tool did not result in a difference inbaseline diameters of ventral tail arteries (means ± SEM; no noise control 344.14 ± 6.77,noise restraint control 344.42 ± 18.65, impact 356.85 ± 14.64) or dose dependent responsesto PE, UK14304 or ACh (Fig. 2Fig. 2.


The effects of impact vibration on peripheral blood vessels and nerves.

Krajnak KM, Waugh S, Johnson C, Miller GR, Xu X, Warren C, Dong RG - Ind Health (2013)

Dose-dependent vasoconstriction of the ventral tail artery in response to the α1- andα2C-adrenoreceptor agonists phenylephrine (A) and UK14304 (B) was not affected byexposure to impact vibration or noise from the riveting gun. Acetylcholine-inducedredilation (C) also was not altered by these exposures. Data are expressed as meanchanges (i.e.,% constriction from baseline or % redilation from constricted baseline ±SEM).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4202742&req=5

fig_002: Dose-dependent vasoconstriction of the ventral tail artery in response to the α1- andα2C-adrenoreceptor agonists phenylephrine (A) and UK14304 (B) was not affected byexposure to impact vibration or noise from the riveting gun. Acetylcholine-inducedredilation (C) also was not altered by these exposures. Data are expressed as meanchanges (i.e.,% constriction from baseline or % redilation from constricted baseline ±SEM).
Mentions: Exposure to impact vibration or the noise of the tool did not result in a difference inbaseline diameters of ventral tail arteries (means ± SEM; no noise control 344.14 ± 6.77,noise restraint control 344.42 ± 18.65, impact 356.85 ± 14.64) or dose dependent responsesto PE, UK14304 or ACh (Fig. 2Fig. 2.

Bottom Line: Responsiveness of the ventral tail artery to adrenoreceptor-mediated vasoconstriction and acetylcholine-mediated re-dilation was measured ex vivo.Ventral tail nerves and nerve endings in the skin were assessed using morphological and immunohistochemical techniques.Impact vibration did not alter vascular responsiveness to any factors or affect trunk nerves.

View Article: PubMed Central - PubMed

Affiliation: Engineering and Controls Technology Branch, National Institutes for Occupational Safety and Health, USA.

ABSTRACT
Research regarding the risk of developing hand-arm vibration syndrome after exposure to impact vibration has produced conflicting results. This study used an established animal model of vibration-induced dysfunction to determine how exposure to impact vibration affects peripheral blood vessels and nerves. The tails of male rats were exposed to a single bout of impact vibration (15 min exposure, at a dominant frequency of 30 Hz and an unweighted acceleration of approximately 345 m/s(2)) generated by a riveting hammer. Responsiveness of the ventral tail artery to adrenoreceptor-mediated vasoconstriction and acetylcholine-mediated re-dilation was measured ex vivo. Ventral tail nerves and nerve endings in the skin were assessed using morphological and immunohistochemical techniques. Impact vibration did not alter vascular responsiveness to any factors or affect trunk nerves. However, 4 days following exposure there was an increase in protein-gene product (PGP) 9.5 staining around hair follicles. A single exposure to impact vibration, with the exposure characteristics described above, affects peripheral nerves but not blood vessels.

Show MeSH
Related in: MedlinePlus