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Outcome of neoadjuvant chemotherapy in locally advanced breast cancer: A tertiary care centre experience.

Bhattacharyya T, Sharma SC, Yadav BS, Singh R, Singh G - Indian J Med Paediatr Oncol (2014)

Bottom Line: Various factors influencing response to NACT and clinical outcome were identified and analyzed.Nodal status, response to chemotherapy, pathological tumor size <3 cm and extracapsular extension (ECE) came out to be important prognostic factors in this study.Clinicopathological variables such as nodal status, response to chemotherapy, pathological tumor size and presence of ECE had significant impact on disease free survival.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiation Oncology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

ABSTRACT

Background: Introduction of neoadjuvant chemotherapy (NACT) has dramatically changed the management of locally advanced breast cancer (LABC). However, very few randomized trials of NACT have been carried out specifically in LABC patients in our country. In this retrospective analysis, we presented our experience with NACT in LABC patients.

Materials and methods: Medical records of 148 patients of stage III LABC patients treated with NACT, followed by surgery and radiotherapy from January 2006 to December 2010 were reviewed. Clinical and pathological responses to different chemotherapy regimens were assessed according to World Health Organization criteria. Various factors influencing response to NACT and clinical outcome were identified and analyzed.

Results: A total of 90 (60.8%) patients received anthracycline-based chemotherapy and 52 (35.1%) patients received mixed anthracycline and taxane-based chemotherapy.119 patients (80.4%) responded to NACT either in the form of complete or partial response (PR). Complete response was seen in 27 (18.2%) patients and 92 (62.2%) patients showed PR after NACT. Pathological complete response was seen in 24 (16.2%) patients-. At a median follow-up period of 44 months 36 patients (24.3%) developed relapse of which six patients developed locoregional recurrence, while 28 (18.9%) patients developed distant metastasis. Nodal status, response to chemotherapy, pathological tumor size <3 cm and extracapsular extension (ECE) came out to be important prognostic factors in this study.

Conclusion: Neoadjuvant chemotherapy is a reasonable alternative to upfront surgery in the management of LABC. Clinicopathological variables such as nodal status, response to chemotherapy, pathological tumor size and presence of ECE had significant impact on disease free survival.

No MeSH data available.


Related in: MedlinePlus

Kaplan–Meier curve showing impact of nodal status on disease free survival
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Figure 1: Kaplan–Meier curve showing impact of nodal status on disease free survival

Mentions: Patients with N0 or N1 disease had better 5 year DFS when compared to patients with N2 or N3 disease (84% vs. 48%; P = 0.04) [Figure 1]. Different chemotherapy schedules had no significant impact on DFS. Patients who had responded to chemotherapy (CR + PR) had significantly better 5 year DFS than nonresponders (SD + PD) (80% vs. 15% P = 0.02). The patients who had achieved a pathological tumor size of <3 cm had better DFS when compared to patients with pathological tumor size of >3 cm (93% vs. 22% P = 0.03) [Figure 2]. Presence of ECE was also associated with higher distant relapse. 5 year DFS was 24% in patients who had ECE as compared to 89% in patient who had no ECE. (P = 0.025) [Figure 3]. Age, menopausal status, hormone receptor profile, lymphovascular space invasion, margin positivity had no significant impact on DFS as shown in Table 3.


Outcome of neoadjuvant chemotherapy in locally advanced breast cancer: A tertiary care centre experience.

Bhattacharyya T, Sharma SC, Yadav BS, Singh R, Singh G - Indian J Med Paediatr Oncol (2014)

Kaplan–Meier curve showing impact of nodal status on disease free survival
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4202618&req=5

Figure 1: Kaplan–Meier curve showing impact of nodal status on disease free survival
Mentions: Patients with N0 or N1 disease had better 5 year DFS when compared to patients with N2 or N3 disease (84% vs. 48%; P = 0.04) [Figure 1]. Different chemotherapy schedules had no significant impact on DFS. Patients who had responded to chemotherapy (CR + PR) had significantly better 5 year DFS than nonresponders (SD + PD) (80% vs. 15% P = 0.02). The patients who had achieved a pathological tumor size of <3 cm had better DFS when compared to patients with pathological tumor size of >3 cm (93% vs. 22% P = 0.03) [Figure 2]. Presence of ECE was also associated with higher distant relapse. 5 year DFS was 24% in patients who had ECE as compared to 89% in patient who had no ECE. (P = 0.025) [Figure 3]. Age, menopausal status, hormone receptor profile, lymphovascular space invasion, margin positivity had no significant impact on DFS as shown in Table 3.

Bottom Line: Various factors influencing response to NACT and clinical outcome were identified and analyzed.Nodal status, response to chemotherapy, pathological tumor size <3 cm and extracapsular extension (ECE) came out to be important prognostic factors in this study.Clinicopathological variables such as nodal status, response to chemotherapy, pathological tumor size and presence of ECE had significant impact on disease free survival.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiation Oncology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

ABSTRACT

Background: Introduction of neoadjuvant chemotherapy (NACT) has dramatically changed the management of locally advanced breast cancer (LABC). However, very few randomized trials of NACT have been carried out specifically in LABC patients in our country. In this retrospective analysis, we presented our experience with NACT in LABC patients.

Materials and methods: Medical records of 148 patients of stage III LABC patients treated with NACT, followed by surgery and radiotherapy from January 2006 to December 2010 were reviewed. Clinical and pathological responses to different chemotherapy regimens were assessed according to World Health Organization criteria. Various factors influencing response to NACT and clinical outcome were identified and analyzed.

Results: A total of 90 (60.8%) patients received anthracycline-based chemotherapy and 52 (35.1%) patients received mixed anthracycline and taxane-based chemotherapy.119 patients (80.4%) responded to NACT either in the form of complete or partial response (PR). Complete response was seen in 27 (18.2%) patients and 92 (62.2%) patients showed PR after NACT. Pathological complete response was seen in 24 (16.2%) patients-. At a median follow-up period of 44 months 36 patients (24.3%) developed relapse of which six patients developed locoregional recurrence, while 28 (18.9%) patients developed distant metastasis. Nodal status, response to chemotherapy, pathological tumor size <3 cm and extracapsular extension (ECE) came out to be important prognostic factors in this study.

Conclusion: Neoadjuvant chemotherapy is a reasonable alternative to upfront surgery in the management of LABC. Clinicopathological variables such as nodal status, response to chemotherapy, pathological tumor size and presence of ECE had significant impact on disease free survival.

No MeSH data available.


Related in: MedlinePlus