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Current status of hematopoietic stem cell transplant in chronic myeloid leukemia.

Gupta A, Khattry N - Indian J Med Paediatr Oncol (2014)

Bottom Line: Indications for hematopoietic stem cell transplant (HSCT) in chronic myeloid leukemia (CML) have changed over time.This change has largely been influenced by the advent of tyrosine kinase inhibitors, increased understanding of the mechanisms underlying disease phase progression as well as drug resistance, refinement of transplant techniques and exploitation of graft versus leukemia effect in this disease.Here, we have discussed the status of HSCT in CML in the present era with regards to the current indications, factors determining outcome and management strategies for posttransplant relapse.

View Article: PubMed Central - PubMed

Affiliation: Department of Medical Oncology, Bone Marrow Transplant Unit, ACTREC, Tata Memorial Centre, Mumbai, Maharashtra, India.

ABSTRACT
Indications for hematopoietic stem cell transplant (HSCT) in chronic myeloid leukemia (CML) have changed over time. This change has largely been influenced by the advent of tyrosine kinase inhibitors, increased understanding of the mechanisms underlying disease phase progression as well as drug resistance, refinement of transplant techniques and exploitation of graft versus leukemia effect in this disease. Here, we have discussed the status of HSCT in CML in the present era with regards to the current indications, factors determining outcome and management strategies for posttransplant relapse.

No MeSH data available.


Related in: MedlinePlus

Algorithm for consideration of hematopoietic stem cell transplant in chronic myeloid leukemia
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Figure 1: Algorithm for consideration of hematopoietic stem cell transplant in chronic myeloid leukemia

Mentions: Thus, current indications for transplant in CML include [Figure 1]:


Current status of hematopoietic stem cell transplant in chronic myeloid leukemia.

Gupta A, Khattry N - Indian J Med Paediatr Oncol (2014)

Algorithm for consideration of hematopoietic stem cell transplant in chronic myeloid leukemia
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4202616&req=5

Figure 1: Algorithm for consideration of hematopoietic stem cell transplant in chronic myeloid leukemia
Mentions: Thus, current indications for transplant in CML include [Figure 1]:

Bottom Line: Indications for hematopoietic stem cell transplant (HSCT) in chronic myeloid leukemia (CML) have changed over time.This change has largely been influenced by the advent of tyrosine kinase inhibitors, increased understanding of the mechanisms underlying disease phase progression as well as drug resistance, refinement of transplant techniques and exploitation of graft versus leukemia effect in this disease.Here, we have discussed the status of HSCT in CML in the present era with regards to the current indications, factors determining outcome and management strategies for posttransplant relapse.

View Article: PubMed Central - PubMed

Affiliation: Department of Medical Oncology, Bone Marrow Transplant Unit, ACTREC, Tata Memorial Centre, Mumbai, Maharashtra, India.

ABSTRACT
Indications for hematopoietic stem cell transplant (HSCT) in chronic myeloid leukemia (CML) have changed over time. This change has largely been influenced by the advent of tyrosine kinase inhibitors, increased understanding of the mechanisms underlying disease phase progression as well as drug resistance, refinement of transplant techniques and exploitation of graft versus leukemia effect in this disease. Here, we have discussed the status of HSCT in CML in the present era with regards to the current indications, factors determining outcome and management strategies for posttransplant relapse.

No MeSH data available.


Related in: MedlinePlus