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Interaction between Analgesic Effect of Nano and Conventional size of Zinc Oxide and Opioidergic System Activity in Animal Model of Acute Pain.

Kesmati M, Torabi M - Basic Clin Neurosci (2014)

Bottom Line: Today Nano-medicine tries to produce new drugs to reduce the dosage and side effects of their conventional forms.Data indicated that both of ZnO supplements reduced latency time in dose and time dependent on the effect of nZnO was higher than cZnO.It seems that nZnO has more efficacy than its conventional form to showing analgesic effect that probably is related to the physicochemical properties of nZnO.

View Article: PubMed Central - PubMed

Affiliation: Department of Biology, Faculty of Science, Shahid Chamran Univercity, Ahvaz,Iran.

ABSTRACT

Introduction: Today Nano-medicine tries to produce new drugs to reduce the dosage and side effects of their conventional forms. According to the interaction between zinc and opioidergic system activity, this study has investigated the effect of new kind of zinc supplement, nano zinc oxide (nZnO), in compared to its conventional form (cZnO), in presence and absence of opioidergic system activity on acute pain.

Methods: Adult male Wistar rats (weighting 200±20gr) divided into groups: control (receiving saline %0.9), nZnO (1, 5, 10, 20 mg/kg), cZnO (1, 5, 10, 20 mg/kg), naloxone 1mg/kg, morphine 6 mg/kg, and co-injected groups of morphine and/or naloxone with nZnO (5mg/kg) and/or cZnO 10 mg/kg. Hot plate assay was used to evaluation of nociception and post injected latencies were recorded every 30 min for 90 min after I.P. injections of drugs. In co-injected groups latency time recorded after 60 minutes.

Results: Data indicated that both of ZnO supplements reduced latency time in dose and time dependent on the effect of nZnO was higher than cZnO. Also these components could improve anti-nociception effect of morphine and naloxone could not change the effect of these supplements.

Discussion: It seems that nZnO has more efficacy than its conventional form to showing analgesic effect that probably is related to the physicochemical properties of nZnO. Also may be these supplements have interaction with opioideric system in body.

No MeSH data available.


Related in: MedlinePlus

The effect of morphine (6mg/kg) and naloxone (1mg/kg) on latency times to pain stimulus: each line show the mean ± SEM for every drugs in four times (every 30 min from 0 up to 90). Control group received saline/saline, other groups received morphine or naloxone / saline. *P < 0.05 show significant difference between morphine 6mg/kg and control group at the same time.
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Figure 0003: The effect of morphine (6mg/kg) and naloxone (1mg/kg) on latency times to pain stimulus: each line show the mean ± SEM for every drugs in four times (every 30 min from 0 up to 90). Control group received saline/saline, other groups received morphine or naloxone / saline. *P < 0.05 show significant difference between morphine 6mg/kg and control group at the same time.

Mentions: Figure 3 shows that morphine 6 mg/kg could reduce latency time to pain stimulus 60 minutes after injection in compared to control group at the same time [at 60 minutes F(2:15)= 5.80, P = 0.05] while naloxone 1mg/kg couldn’t change latency time in compared to control group or morphine 6mg/kg in any time [at 0 min F(2:15) = 0.02, NS, at 30 minutes F(2:15), NS, at 90 minutes F(2:15), NS]. We selected this time to evaluate the effect of opioidergic system activity on analgesic effect of cZnO and nZnO.


Interaction between Analgesic Effect of Nano and Conventional size of Zinc Oxide and Opioidergic System Activity in Animal Model of Acute Pain.

Kesmati M, Torabi M - Basic Clin Neurosci (2014)

The effect of morphine (6mg/kg) and naloxone (1mg/kg) on latency times to pain stimulus: each line show the mean ± SEM for every drugs in four times (every 30 min from 0 up to 90). Control group received saline/saline, other groups received morphine or naloxone / saline. *P < 0.05 show significant difference between morphine 6mg/kg and control group at the same time.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4202607&req=5

Figure 0003: The effect of morphine (6mg/kg) and naloxone (1mg/kg) on latency times to pain stimulus: each line show the mean ± SEM for every drugs in four times (every 30 min from 0 up to 90). Control group received saline/saline, other groups received morphine or naloxone / saline. *P < 0.05 show significant difference between morphine 6mg/kg and control group at the same time.
Mentions: Figure 3 shows that morphine 6 mg/kg could reduce latency time to pain stimulus 60 minutes after injection in compared to control group at the same time [at 60 minutes F(2:15)= 5.80, P = 0.05] while naloxone 1mg/kg couldn’t change latency time in compared to control group or morphine 6mg/kg in any time [at 0 min F(2:15) = 0.02, NS, at 30 minutes F(2:15), NS, at 90 minutes F(2:15), NS]. We selected this time to evaluate the effect of opioidergic system activity on analgesic effect of cZnO and nZnO.

Bottom Line: Today Nano-medicine tries to produce new drugs to reduce the dosage and side effects of their conventional forms.Data indicated that both of ZnO supplements reduced latency time in dose and time dependent on the effect of nZnO was higher than cZnO.It seems that nZnO has more efficacy than its conventional form to showing analgesic effect that probably is related to the physicochemical properties of nZnO.

View Article: PubMed Central - PubMed

Affiliation: Department of Biology, Faculty of Science, Shahid Chamran Univercity, Ahvaz,Iran.

ABSTRACT

Introduction: Today Nano-medicine tries to produce new drugs to reduce the dosage and side effects of their conventional forms. According to the interaction between zinc and opioidergic system activity, this study has investigated the effect of new kind of zinc supplement, nano zinc oxide (nZnO), in compared to its conventional form (cZnO), in presence and absence of opioidergic system activity on acute pain.

Methods: Adult male Wistar rats (weighting 200±20gr) divided into groups: control (receiving saline %0.9), nZnO (1, 5, 10, 20 mg/kg), cZnO (1, 5, 10, 20 mg/kg), naloxone 1mg/kg, morphine 6 mg/kg, and co-injected groups of morphine and/or naloxone with nZnO (5mg/kg) and/or cZnO 10 mg/kg. Hot plate assay was used to evaluation of nociception and post injected latencies were recorded every 30 min for 90 min after I.P. injections of drugs. In co-injected groups latency time recorded after 60 minutes.

Results: Data indicated that both of ZnO supplements reduced latency time in dose and time dependent on the effect of nZnO was higher than cZnO. Also these components could improve anti-nociception effect of morphine and naloxone could not change the effect of these supplements.

Discussion: It seems that nZnO has more efficacy than its conventional form to showing analgesic effect that probably is related to the physicochemical properties of nZnO. Also may be these supplements have interaction with opioideric system in body.

No MeSH data available.


Related in: MedlinePlus