A Polychaete's powerful punch: venom gland transcriptomics of Glycera reveals a complex cocktail of toxin homologs.
Bottom Line: These transcripts represent 20 known toxin classes that have been convergently recruited into animal venoms, as well as transcripts potentially coding for Glycera-specific toxins.This complex mixture of toxin homologs suggests that bloodworms employ venom while predating on macroscopic prey, casting doubt on the previously widespread opinion that G. dibranchiata is a detritivore.Our results further show that researchers should be aware that different assembly methods, as well as different methods of homology prediction, can influence the transcriptomic profiling of venom glands.
Affiliation: Department of Life Sciences, The Natural History Museum, London, United Kingdom email@example.com firstname.lastname@example.org email@example.com.Show MeSH
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Mentions: The Glycera ShKT domain transcripts contain the six conserved cysteine residues that are characteristic for this domain (fig. 6). The transcripts show three basic domain arrangements: Metalloproteinase M12 + ShKT, SUEL-like Lectin +ShKT, and CAP + ShKT (see supplementary fig. S2, Supplementary Material online). However, within and between these three basic types the transcripts vary widely in the presence of putative cleavage sites, signal peptides, transmembrane regions, tandem repeats of ShKT domain variants, and the presence of additional domain types.Fig. 6.—
Affiliation: Department of Life Sciences, The Natural History Museum, London, United Kingdom firstname.lastname@example.org email@example.com firstname.lastname@example.org.