RBE and OER within the spread-out Bragg peak for proton beam therapy: in vitro study at the Proton Medical Research Center at the University of Tsukuba.
Bottom Line: The OER was 2.84, 2.60, 2.63 and 2.76 for positions A, B, C and D, respectively.There were no significant differences in either the RBE(plateau) or the OER between these three positions within the SOBP.In conclusion, biological homogeneity need not necessarily be taken into account for treatment planning for proton beam therapy at the University of Tsukuba.
Affiliation: Proton Medical Research Center, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8575, Japan.Show MeSH
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Mentions: The dishes with cells were filled with 1.2 ml of MEM only and transferred into the irradiation chamber. For irradiation under hypoxic conditions, the chamber was flushed for 1 h before irradiation with 1000 ml/min of a mixture of 95% N2 and 5% CO2 that had been bubbled through water to maintain high humidity (Fig. 1a). The oxygen concentration was controlled to a partial pressure of <0.2 mmHg, as reported previously [3, 10].
Affiliation: Proton Medical Research Center, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8575, Japan.