RBE and OER within the spread-out Bragg peak for proton beam therapy: in vitro study at the Proton Medical Research Center at the University of Tsukuba.
Bottom Line: Under the normoxic condition, the RBE(plateau) was 1.00, 0.99 and 1.09 for positions B, C and D, respectively.The OER was 2.84, 2.60, 2.63 and 2.76 for positions A, B, C and D, respectively.There were no significant differences in either the RBE(plateau) or the OER between these three positions within the SOBP.
Affiliation: Proton Medical Research Center, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8575, Japan.Show MeSH
Related in: MedlinePlus
Mentions: The dishes with cells were filled with 1.2 ml of MEM only and transferred into the irradiation chamber. For irradiation under hypoxic conditions, the chamber was flushed for 1 h before irradiation with 1000 ml/min of a mixture of 95% N2 and 5% CO2 that had been bubbled through water to maintain high humidity (Fig. 1a). The oxygen concentration was controlled to a partial pressure of <0.2 mmHg, as reported previously [3, 10].
Affiliation: Proton Medical Research Center, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8575, Japan.