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RBE and OER within the spread-out Bragg peak for proton beam therapy: in vitro study at the Proton Medical Research Center at the University of Tsukuba.

Kanemoto A, Hirayama R, Moritake T, Furusawa Y, Sun L, Sakae T, Kuno A, Terunuma T, Yasuoka K, Mori Y, Tsuboi K, Sakurai H - J. Radiat. Res. (2014)

Bottom Line: Under the normoxic condition, the RBE(plateau) was 1.00, 0.99 and 1.09 for positions B, C and D, respectively.The OER was 2.84, 2.60, 2.63 and 2.76 for positions A, B, C and D, respectively.There were no significant differences in either the RBE(plateau) or the OER between these three positions within the SOBP.

View Article: PubMed Central - PubMed

Affiliation: Proton Medical Research Center, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8575, Japan.

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The setup for the sample irradiation (a and b) and depth–dose distribution of the spread-out Bragg peak (SOBP) of proton beams (c). The closed squares represent the relative absorbed dose at various depths in the water-equivalent phantom. The solid line shows a curve fit freehand.
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RRU043F1: The setup for the sample irradiation (a and b) and depth–dose distribution of the spread-out Bragg peak (SOBP) of proton beams (c). The closed squares represent the relative absorbed dose at various depths in the water-equivalent phantom. The solid line shows a curve fit freehand.

Mentions: The dishes with cells were filled with 1.2 ml of MEM only and transferred into the irradiation chamber. For irradiation under hypoxic conditions, the chamber was flushed for 1 h before irradiation with 1000 ml/min of a mixture of 95% N2 and 5% CO2 that had been bubbled through water to maintain high humidity (Fig. 1a). The oxygen concentration was controlled to a partial pressure of <0.2 mmHg, as reported previously [3, 10].


RBE and OER within the spread-out Bragg peak for proton beam therapy: in vitro study at the Proton Medical Research Center at the University of Tsukuba.

Kanemoto A, Hirayama R, Moritake T, Furusawa Y, Sun L, Sakae T, Kuno A, Terunuma T, Yasuoka K, Mori Y, Tsuboi K, Sakurai H - J. Radiat. Res. (2014)

The setup for the sample irradiation (a and b) and depth–dose distribution of the spread-out Bragg peak (SOBP) of proton beams (c). The closed squares represent the relative absorbed dose at various depths in the water-equivalent phantom. The solid line shows a curve fit freehand.
© Copyright Policy - creative-commons
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4202301&req=5

RRU043F1: The setup for the sample irradiation (a and b) and depth–dose distribution of the spread-out Bragg peak (SOBP) of proton beams (c). The closed squares represent the relative absorbed dose at various depths in the water-equivalent phantom. The solid line shows a curve fit freehand.
Mentions: The dishes with cells were filled with 1.2 ml of MEM only and transferred into the irradiation chamber. For irradiation under hypoxic conditions, the chamber was flushed for 1 h before irradiation with 1000 ml/min of a mixture of 95% N2 and 5% CO2 that had been bubbled through water to maintain high humidity (Fig. 1a). The oxygen concentration was controlled to a partial pressure of <0.2 mmHg, as reported previously [3, 10].

Bottom Line: Under the normoxic condition, the RBE(plateau) was 1.00, 0.99 and 1.09 for positions B, C and D, respectively.The OER was 2.84, 2.60, 2.63 and 2.76 for positions A, B, C and D, respectively.There were no significant differences in either the RBE(plateau) or the OER between these three positions within the SOBP.

View Article: PubMed Central - PubMed

Affiliation: Proton Medical Research Center, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8575, Japan.

Show MeSH
Related in: MedlinePlus