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Investigation into the role of the cholinergic system in radiation-induced damage in the rat liver and ileum.

Özyurt H, Özden AS, Çevik Ö, Özgen Z, Cadirci S, Elmas MA, Ercan F, Şener G, Gören MZ - J. Radiat. Res. (2014)

Bottom Line: Plasma levels of IL-1β and TNF-α increased significantly following radiation (P < 0.01 and P < 0.001, respectively) as compared with non-irradiated controls, and physostigmine treatment prevented the increase in the pro-inflammatory cytokines (P < 0.01 and P < 0.001, respectively).Plasma IL-10 levels were not found to be significantly changed following radiation, whereas physostigmine augmented IL-10 levels during the late phase (P < 0.01).Physostigmine experiments suggested that ACh has a radio-protective effect not involving the muscarinic receptors.

View Article: PubMed Central - PubMed

Affiliation: Dr Lutfi Kirdar Kartal Training and Research Hospital, Radiation Oncology, 34865 Istanbul, Turkey.

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Representative micrographs of the ileal tissue in the experimental groups (a). Regular villi morphology with epithelium and lamina propria in the control group (b). Epithelial desquamation (arrows) and severe inflammatory cell infiltration (stars) in the irradiated rats in early (b) and late (c) phases. Regular surface epithelium (arrows) and moderate inflammation in atropine-treated irradiated rats in early (d) and late (e) phases. Regular surface epithelium (arrows) and mild inflammation in physostigmine-treated irradiated rats in early (f) and late (g) phases. H&E staining, scale bars: 20 µm, insets: 100 µm.
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RRU039F7: Representative micrographs of the ileal tissue in the experimental groups (a). Regular villi morphology with epithelium and lamina propria in the control group (b). Epithelial desquamation (arrows) and severe inflammatory cell infiltration (stars) in the irradiated rats in early (b) and late (c) phases. Regular surface epithelium (arrows) and moderate inflammation in atropine-treated irradiated rats in early (d) and late (e) phases. Regular surface epithelium (arrows) and mild inflammation in physostigmine-treated irradiated rats in early (f) and late (g) phases. H&E staining, scale bars: 20 µm, insets: 100 µm.

Mentions: The light microscopy findings of the small-bowel mucosa were entirely normal in the control group. Severe degeneration of villi with epithelial desquamation and severe inflammatory cell infiltration were observed in both early- and late-phase irradiated groups. Atropine treatment produced mild degeneration in the surface epithelium and moderate inflammation, and physostigmine treatment produced mild degeneration in the surface epithelium and mild inflammation in the early and late phases in irradiated groups (Fig. 7).Fig. 7.


Investigation into the role of the cholinergic system in radiation-induced damage in the rat liver and ileum.

Özyurt H, Özden AS, Çevik Ö, Özgen Z, Cadirci S, Elmas MA, Ercan F, Şener G, Gören MZ - J. Radiat. Res. (2014)

Representative micrographs of the ileal tissue in the experimental groups (a). Regular villi morphology with epithelium and lamina propria in the control group (b). Epithelial desquamation (arrows) and severe inflammatory cell infiltration (stars) in the irradiated rats in early (b) and late (c) phases. Regular surface epithelium (arrows) and moderate inflammation in atropine-treated irradiated rats in early (d) and late (e) phases. Regular surface epithelium (arrows) and mild inflammation in physostigmine-treated irradiated rats in early (f) and late (g) phases. H&E staining, scale bars: 20 µm, insets: 100 µm.
© Copyright Policy - creative-commons
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4202297&req=5

RRU039F7: Representative micrographs of the ileal tissue in the experimental groups (a). Regular villi morphology with epithelium and lamina propria in the control group (b). Epithelial desquamation (arrows) and severe inflammatory cell infiltration (stars) in the irradiated rats in early (b) and late (c) phases. Regular surface epithelium (arrows) and moderate inflammation in atropine-treated irradiated rats in early (d) and late (e) phases. Regular surface epithelium (arrows) and mild inflammation in physostigmine-treated irradiated rats in early (f) and late (g) phases. H&E staining, scale bars: 20 µm, insets: 100 µm.
Mentions: The light microscopy findings of the small-bowel mucosa were entirely normal in the control group. Severe degeneration of villi with epithelial desquamation and severe inflammatory cell infiltration were observed in both early- and late-phase irradiated groups. Atropine treatment produced mild degeneration in the surface epithelium and moderate inflammation, and physostigmine treatment produced mild degeneration in the surface epithelium and mild inflammation in the early and late phases in irradiated groups (Fig. 7).Fig. 7.

Bottom Line: Plasma levels of IL-1β and TNF-α increased significantly following radiation (P < 0.01 and P < 0.001, respectively) as compared with non-irradiated controls, and physostigmine treatment prevented the increase in the pro-inflammatory cytokines (P < 0.01 and P < 0.001, respectively).Plasma IL-10 levels were not found to be significantly changed following radiation, whereas physostigmine augmented IL-10 levels during the late phase (P < 0.01).Physostigmine experiments suggested that ACh has a radio-protective effect not involving the muscarinic receptors.

View Article: PubMed Central - PubMed

Affiliation: Dr Lutfi Kirdar Kartal Training and Research Hospital, Radiation Oncology, 34865 Istanbul, Turkey.

Show MeSH
Related in: MedlinePlus