Investigation into the role of the cholinergic system in radiation-induced damage in the rat liver and ileum.
Bottom Line: Plasma levels of IL-1β and TNF-α increased significantly following radiation (P < 0.01 and P < 0.001, respectively) as compared with non-irradiated controls, and physostigmine treatment prevented the increase in the pro-inflammatory cytokines (P < 0.01 and P < 0.001, respectively).Plasma IL-10 levels were not found to be significantly changed following radiation, whereas physostigmine augmented IL-10 levels during the late phase (P < 0.01).Physostigmine experiments suggested that ACh has a radio-protective effect not involving the muscarinic receptors.
Affiliation: Dr Lutfi Kirdar Kartal Training and Research Hospital, Radiation Oncology, 34865 Istanbul, Turkey.Show MeSH
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Mentions: The light microscopy ﬁndings of the small-bowel mucosa were entirely normal in the control group. Severe degeneration of villi with epithelial desquamation and severe inflammatory cell infiltration were observed in both early- and late-phase irradiated groups. Atropine treatment produced mild degeneration in the surface epithelium and moderate inﬂammation, and physostigmine treatment produced mild degeneration in the surface epithelium and mild inﬂammation in the early and late phases in irradiated groups (Fig. 7).Fig. 7.
Affiliation: Dr Lutfi Kirdar Kartal Training and Research Hospital, Radiation Oncology, 34865 Istanbul, Turkey.