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Decreased peripheral arterial volume distensibility in patients with branch retinal vein occlusion in comparison with normal subjects.

Chen Z, Mao L, Liu C, Blake JR, Zheng D - Sci Rep (2014)

Bottom Line: In comparison with the normal subjects, after adjusting for pulse pressure, baPWV in the BRVO patients was significantly higher by 2.3 m/s (P < 0.01) and arterial distensibility was significantly lower by 0.015% per mmHg (P < 0.01).Peripheral arterial distensibility has been shown to be significantly lower in BRVO patients in comparison with normal subjects.The more prominent effect of SBP, DBP and ageing on arterial distensibility indicates the potential underlying mechanisms of the interaction between higher blood pressures, ageing and BRVO disease.

View Article: PubMed Central - PubMed

Affiliation: Eye Center, Second Affiliated Hospital, School of Medicine, Zhejiang University, China.

ABSTRACT
This study aimed to quantify arterial volume distensibility in patients with branch retinal vein occlusion (BRVO) in comparison with normal subjects and to investigate factors associated with their differences. 40 normal subjects and 30 BRVO patients were studied. Brachial-ankle pulse wave velocity (baPWV) was measured to determine arterial volume distensibility. In comparison with the normal subjects, after adjusting for pulse pressure, baPWV in the BRVO patients was significantly higher by 2.3 m/s (P < 0.01) and arterial distensibility was significantly lower by 0.015% per mmHg (P < 0.01). No subject in the normal group had an arterial distensibility lower than 0.04% per mmHg, in comparison with 67% (20/30) in the BRVO group. Arterial distensibility was significantly related to systolic and diastolic blood pressures (SBP and DBP) and ageing for both groups (all P < 0.05), but in the BRVO group, blood pressures and ageing had more prominent effect on arterial volume distensibility. Peripheral arterial distensibility has been shown to be significantly lower in BRVO patients in comparison with normal subjects. The more prominent effect of SBP, DBP and ageing on arterial distensibility indicates the potential underlying mechanisms of the interaction between higher blood pressures, ageing and BRVO disease.

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Brachial-ankle pulse wave velocity (baPWV) as a function of systolic blood pressure (SBP), diastolic blood pressure (DBP) and age for the normal (A1–A3) and BRVO groups (B1–B3).The regression lines with P values and R values are also shown.
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f2: Brachial-ankle pulse wave velocity (baPWV) as a function of systolic blood pressure (SBP), diastolic blood pressure (DBP) and age for the normal (A1–A3) and BRVO groups (B1–B3).The regression lines with P values and R values are also shown.

Mentions: As given in Figure 2–3 and Table 3–4, both baPWV and arterial volume distensibilty had significant relationships with SBP and DBP in both normal and BRVO groups (all P < 0.05). It has also been shown that their absolute regression slopes increased in BRVO group. As demonstrated in Table 3 and 4, in the normal group, baPWV increased by 17% for a SBP increase from 90 to 150 mmHg and 21% for a DBP increase from 45 to 105 mmHg. These increases were more than double in the BRVO group (37% against 17% for SBP, and 48% against 21% for DBP). For the same blood pressure increase, more obvious decrease in arterial volume distensibility was obtained in the BRVO group in comparison with the normal group (38% against 30% for SBP, and 56% against 36% for DBP).


Decreased peripheral arterial volume distensibility in patients with branch retinal vein occlusion in comparison with normal subjects.

Chen Z, Mao L, Liu C, Blake JR, Zheng D - Sci Rep (2014)

Brachial-ankle pulse wave velocity (baPWV) as a function of systolic blood pressure (SBP), diastolic blood pressure (DBP) and age for the normal (A1–A3) and BRVO groups (B1–B3).The regression lines with P values and R values are also shown.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4202212&req=5

f2: Brachial-ankle pulse wave velocity (baPWV) as a function of systolic blood pressure (SBP), diastolic blood pressure (DBP) and age for the normal (A1–A3) and BRVO groups (B1–B3).The regression lines with P values and R values are also shown.
Mentions: As given in Figure 2–3 and Table 3–4, both baPWV and arterial volume distensibilty had significant relationships with SBP and DBP in both normal and BRVO groups (all P < 0.05). It has also been shown that their absolute regression slopes increased in BRVO group. As demonstrated in Table 3 and 4, in the normal group, baPWV increased by 17% for a SBP increase from 90 to 150 mmHg and 21% for a DBP increase from 45 to 105 mmHg. These increases were more than double in the BRVO group (37% against 17% for SBP, and 48% against 21% for DBP). For the same blood pressure increase, more obvious decrease in arterial volume distensibility was obtained in the BRVO group in comparison with the normal group (38% against 30% for SBP, and 56% against 36% for DBP).

Bottom Line: In comparison with the normal subjects, after adjusting for pulse pressure, baPWV in the BRVO patients was significantly higher by 2.3 m/s (P < 0.01) and arterial distensibility was significantly lower by 0.015% per mmHg (P < 0.01).Peripheral arterial distensibility has been shown to be significantly lower in BRVO patients in comparison with normal subjects.The more prominent effect of SBP, DBP and ageing on arterial distensibility indicates the potential underlying mechanisms of the interaction between higher blood pressures, ageing and BRVO disease.

View Article: PubMed Central - PubMed

Affiliation: Eye Center, Second Affiliated Hospital, School of Medicine, Zhejiang University, China.

ABSTRACT
This study aimed to quantify arterial volume distensibility in patients with branch retinal vein occlusion (BRVO) in comparison with normal subjects and to investigate factors associated with their differences. 40 normal subjects and 30 BRVO patients were studied. Brachial-ankle pulse wave velocity (baPWV) was measured to determine arterial volume distensibility. In comparison with the normal subjects, after adjusting for pulse pressure, baPWV in the BRVO patients was significantly higher by 2.3 m/s (P < 0.01) and arterial distensibility was significantly lower by 0.015% per mmHg (P < 0.01). No subject in the normal group had an arterial distensibility lower than 0.04% per mmHg, in comparison with 67% (20/30) in the BRVO group. Arterial distensibility was significantly related to systolic and diastolic blood pressures (SBP and DBP) and ageing for both groups (all P < 0.05), but in the BRVO group, blood pressures and ageing had more prominent effect on arterial volume distensibility. Peripheral arterial distensibility has been shown to be significantly lower in BRVO patients in comparison with normal subjects. The more prominent effect of SBP, DBP and ageing on arterial distensibility indicates the potential underlying mechanisms of the interaction between higher blood pressures, ageing and BRVO disease.

Show MeSH
Related in: MedlinePlus