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Ewing's Sarcoma: An Uncommon Breast Tumor.

Meddeb S, Rhim MS, Kouira M, Mestiri S, Bibi M, Yacoubi MT - Clin Pract (2014)

Bottom Line: Indeed, mammography and ultrasonography features are non specific.The histopathological pattern is variable depending on the degree of neuroectodermal differentiation.Immuno-phenotyping is necessary and genetic study is the only confirmatory tool of diagnosis showing a characteristic cytogenetic anomaly; t (11; 22) translocation.

View Article: PubMed Central - PubMed

Affiliation: Department of Gynecology and Obstetrics, Farhat Hached University Hospital , Sousse, Tunisia ; Research Laboratory in Quality of Maternal Health Care in Tunisia , Sousse, Tunisia.

ABSTRACT
Ewing's sarcoma/primitive neuroectodermal tumors (EWS/PNET) are rare malignant and aggressive tumors, usually seen in the trunk and lower limbs of children and young adults. They are uncommon in the breast. We report a case of a 43-year-old woman who developed a painless breast mass. An initial core needle biopsy concluded to a fibrocystic dystrophy contrasting with a rapidly growing mass; thus a large lumpectomy was done. Diagnosis of primary PNET of the breast was established, based on both histopathological examination and immunohistochemical findings. Surgical margins were positive, therefore, left modified radical mastectomy with axillary lymph nodes dissection was performed. The patient was given 6 cycles of adjuvant chemotherapy containing cyclophosphamide, adriamycin and vincristine. Twenty months later, she is in life without recurrence or metastasis. EWS/PNET may impose a diagnostic challenge. Indeed, mammography and ultrasonography features are non specific. The histopathological pattern is variable depending on the degree of neuroectodermal differentiation. Immuno-phenotyping is necessary and genetic study is the only confirmatory tool of diagnosis showing a characteristic cytogenetic anomaly; t (11; 22) translocation.

No MeSH data available.


Related in: MedlinePlus

Goss and ultrasonographic features of the tumor. A) Large breast lump with inflammatory overlying skin. B) Breast masse tissular density scattered by fluid areas.
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fig001: Goss and ultrasonographic features of the tumor. A) Large breast lump with inflammatory overlying skin. B) Breast masse tissular density scattered by fluid areas.

Mentions: Mammography and ultrasonography revealed a superficial well defined oval mass with a soft tissue density and a hypoechoic center. An initial diagnosis of fibroadenoma was suspected and core needle biopsy concluded to a fibrocystic dystrophy. One month later, the patient complaint that the mass progressively grew to the size of 13 cm in diameter with inflammation of the overlying skin and a left axillary lymphadenopathy. Ultrasonographic examination revealed a 10 cm mass scattered with multiple fluid areas (Figure 1).


Ewing's Sarcoma: An Uncommon Breast Tumor.

Meddeb S, Rhim MS, Kouira M, Mestiri S, Bibi M, Yacoubi MT - Clin Pract (2014)

Goss and ultrasonographic features of the tumor. A) Large breast lump with inflammatory overlying skin. B) Breast masse tissular density scattered by fluid areas.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4202187&req=5

fig001: Goss and ultrasonographic features of the tumor. A) Large breast lump with inflammatory overlying skin. B) Breast masse tissular density scattered by fluid areas.
Mentions: Mammography and ultrasonography revealed a superficial well defined oval mass with a soft tissue density and a hypoechoic center. An initial diagnosis of fibroadenoma was suspected and core needle biopsy concluded to a fibrocystic dystrophy. One month later, the patient complaint that the mass progressively grew to the size of 13 cm in diameter with inflammation of the overlying skin and a left axillary lymphadenopathy. Ultrasonographic examination revealed a 10 cm mass scattered with multiple fluid areas (Figure 1).

Bottom Line: Indeed, mammography and ultrasonography features are non specific.The histopathological pattern is variable depending on the degree of neuroectodermal differentiation.Immuno-phenotyping is necessary and genetic study is the only confirmatory tool of diagnosis showing a characteristic cytogenetic anomaly; t (11; 22) translocation.

View Article: PubMed Central - PubMed

Affiliation: Department of Gynecology and Obstetrics, Farhat Hached University Hospital , Sousse, Tunisia ; Research Laboratory in Quality of Maternal Health Care in Tunisia , Sousse, Tunisia.

ABSTRACT
Ewing's sarcoma/primitive neuroectodermal tumors (EWS/PNET) are rare malignant and aggressive tumors, usually seen in the trunk and lower limbs of children and young adults. They are uncommon in the breast. We report a case of a 43-year-old woman who developed a painless breast mass. An initial core needle biopsy concluded to a fibrocystic dystrophy contrasting with a rapidly growing mass; thus a large lumpectomy was done. Diagnosis of primary PNET of the breast was established, based on both histopathological examination and immunohistochemical findings. Surgical margins were positive, therefore, left modified radical mastectomy with axillary lymph nodes dissection was performed. The patient was given 6 cycles of adjuvant chemotherapy containing cyclophosphamide, adriamycin and vincristine. Twenty months later, she is in life without recurrence or metastasis. EWS/PNET may impose a diagnostic challenge. Indeed, mammography and ultrasonography features are non specific. The histopathological pattern is variable depending on the degree of neuroectodermal differentiation. Immuno-phenotyping is necessary and genetic study is the only confirmatory tool of diagnosis showing a characteristic cytogenetic anomaly; t (11; 22) translocation.

No MeSH data available.


Related in: MedlinePlus