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Enhancing epidemiological analysis of intercontinental dispersion of H5N1 viral strains by migratory waterfowl using phylogeography.

Rao DM - BMC Proc (2014)

Bottom Line: The temporo-geospatial characteristics of infection transmission provides corroborating, but novel evidence for rapid genesis of H5N1 lineages in S.E.Asia.The proposed method pinpoints several regions, particularly in the southern hemisphere, as candidates for increased surveillance.

View Article: PubMed Central - HTML - PubMed

Affiliation: CSE Department, Miami University, 510 E. High Street, Oxford 45056 OHIO, USA.

ABSTRACT

Background: Intercontinental migratory waterfowl are the primary vectors for dispersion of H5N1 viruses and have been implicated in several zoonotic epidemics and pandemics. Recent investigations have established that with a single mutation, the virus gains the ability to transmit between humans. Consequently, there is a heightened urgency to identify innovative approaches to proactively mitigate emergent epidemics. Accordingly, a novel methodology combining temporo-geospatial epidemiology and phylogeographic analysis of viral strains is proposed to identify critical epicenters and epidemic pathways along with high risk candidate regions for increased surveillance.

Results: Epidemiological analysis was used to identify 91,245 candidate global infection transmission pathways between 22 high risk waterfowl species. Dominant infection pathways (25,625 and 54,500 in summering and wintering zones) were identified through annotation using phylogeographical data computed from the phylogram of 2417 H5N1 HA isolates (from GISAID EpiFlu database). Annotation of infection pathways in turn delineated 23 influential clades out of 130 clades in the phylogram.

Conclusions: The phylogeographic analyses provides strong cross-validation of epidemic pathways and identifies the dominant pathways for use in other epidemiological and prophylactic studies. The temporo-geospatial characteristics of infection transmission provides corroborating, but novel evidence for rapid genesis of H5N1 lineages in S.E. Asia. The proposed method pinpoints several regions, particularly in the southern hemisphere, as candidates for increased surveillance.

No MeSH data available.


Related in: MedlinePlus

Overview of global ecology of Avian Influenza Viral serotypes, hosts, and vectors are shown.
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Figure 1: Overview of global ecology of Avian Influenza Viral serotypes, hosts, and vectors are shown.

Mentions: The global ecology of avian influenza, is summarized in Figure 1 along with various polymorphic strains. It has been established that migratory waterfowl, especially anseriformes and charadrillformes, play a central role in the global ecology [7,8]. Moreover, migratory waterfowl have been implicated as natural reservoirs, mixing vessels, and intercontinental vectors for various serotypes of avian viruses [8]. Unfortunately, knowledge on global spread of H5N1 is rather limited [9] with ongoing debates regarding its transmission pathways [8,10].


Enhancing epidemiological analysis of intercontinental dispersion of H5N1 viral strains by migratory waterfowl using phylogeography.

Rao DM - BMC Proc (2014)

Overview of global ecology of Avian Influenza Viral serotypes, hosts, and vectors are shown.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4202179&req=5

Figure 1: Overview of global ecology of Avian Influenza Viral serotypes, hosts, and vectors are shown.
Mentions: The global ecology of avian influenza, is summarized in Figure 1 along with various polymorphic strains. It has been established that migratory waterfowl, especially anseriformes and charadrillformes, play a central role in the global ecology [7,8]. Moreover, migratory waterfowl have been implicated as natural reservoirs, mixing vessels, and intercontinental vectors for various serotypes of avian viruses [8]. Unfortunately, knowledge on global spread of H5N1 is rather limited [9] with ongoing debates regarding its transmission pathways [8,10].

Bottom Line: The temporo-geospatial characteristics of infection transmission provides corroborating, but novel evidence for rapid genesis of H5N1 lineages in S.E.Asia.The proposed method pinpoints several regions, particularly in the southern hemisphere, as candidates for increased surveillance.

View Article: PubMed Central - HTML - PubMed

Affiliation: CSE Department, Miami University, 510 E. High Street, Oxford 45056 OHIO, USA.

ABSTRACT

Background: Intercontinental migratory waterfowl are the primary vectors for dispersion of H5N1 viruses and have been implicated in several zoonotic epidemics and pandemics. Recent investigations have established that with a single mutation, the virus gains the ability to transmit between humans. Consequently, there is a heightened urgency to identify innovative approaches to proactively mitigate emergent epidemics. Accordingly, a novel methodology combining temporo-geospatial epidemiology and phylogeographic analysis of viral strains is proposed to identify critical epicenters and epidemic pathways along with high risk candidate regions for increased surveillance.

Results: Epidemiological analysis was used to identify 91,245 candidate global infection transmission pathways between 22 high risk waterfowl species. Dominant infection pathways (25,625 and 54,500 in summering and wintering zones) were identified through annotation using phylogeographical data computed from the phylogram of 2417 H5N1 HA isolates (from GISAID EpiFlu database). Annotation of infection pathways in turn delineated 23 influential clades out of 130 clades in the phylogram.

Conclusions: The phylogeographic analyses provides strong cross-validation of epidemic pathways and identifies the dominant pathways for use in other epidemiological and prophylactic studies. The temporo-geospatial characteristics of infection transmission provides corroborating, but novel evidence for rapid genesis of H5N1 lineages in S.E. Asia. The proposed method pinpoints several regions, particularly in the southern hemisphere, as candidates for increased surveillance.

No MeSH data available.


Related in: MedlinePlus