Dynamic changes in macrophage activation and proliferation during the development and resolution of intestinal inflammation.
Bottom Line: Classically activated Mφs predominate initially (as the inflammation develops) and then, following worm expulsion (as the inflammation resolves), both the resident and inflammatory populations of Mφs become alternatively activated.In conclusion, the recruitment of blood monocytes is the principle mechanism of Mφ accumulation in the large intestine.This study provides a novel insight into the phenotype and behavior of intestinal Mφ during infection-driven inflammation.
Affiliation: Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, United Kingdom firstname.lastname@example.org.Show MeSH
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Mentions: After day 35 postinfection, Ag-stimulated MLN cells from AKR mice released high levels of IFN-γ and IL-17A. Furthermore, on day 42, IL-13, but not IL-5, was also released (Fig. 2), revealing that AKR mice mounted strong Th1 and Th17 responses (and also a delayed and muted Th2 response) to the parasite. In contrast, Ag-stimulated MLN cells from BALB/c mice produced high levels of IL-5 and IL-13, but not IFN-γ postinfection. This was accompanied by a small but significant increase in IL-17A on day 42 (Fig. 2). Therefore, BALB/c mice mounted a strong Th2 response (and also a weak and delayed Th17 response) to T. muris. MLN cells from C57BL/6 mice released high levels of all four cytokines after day 21 postinfection (Fig. 2). Therefore, C57BL/6 mice mounted strong Th1, Th2, and Th17 responses. AKR mice failed to expel T. muris and a chronic infection ensued. In contrast, BALB/c and C57BL/6 mice were both resistant. However, BALB/c mice expelled the parasite more rapidly than C57BL/6 mice (Fig. 3A).
Affiliation: Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, United Kingdom email@example.com.