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Large gastrointestinal stromal tumor and advanced adenocarcinoma in the rectum coexistent with an incidental prostate carcinoma: A case report.

Suzuki T, Suwa K, Hanyu K, Okamoto T, Fujita T, Yanaga K - Int J Surg Case Rep (2014)

Bottom Line: We herein describe a 76-year-old man with a large gastrointestinal stromal tumor along with an advanced adenocarcinoma in the rectum that coexisted with prostate carcinoma.The patient was given adjuvant chemotherapy with imatinib and remains disease-free as of 12 months after surgery.Radical surgery with perioperative adjuvant chemotherapy using tyrosine kinase inhibitors is the choice for treatment of large GISTs with a malignant potential.

View Article: PubMed Central - PubMed

Affiliation: Department of Surgery, The Jikei University, Daisan Hospital, Japan. Electronic address: toshiaki1129jp@yahoo.co.jp.

No MeSH data available.


Related in: MedlinePlus

Magnetic resonance imaging. (A) Transverse T1-weighted image showing a homogeneous mass with intermediate signal intensity (arrow). (B) Transverse T2-weighted image showing a heterogeneous mass with high signal intensity (arrow). (C) Sagittal T2-weighted image could not show clear delineation between the tumor and the prostate (arrow).
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fig0005: Magnetic resonance imaging. (A) Transverse T1-weighted image showing a homogeneous mass with intermediate signal intensity (arrow). (B) Transverse T2-weighted image showing a heterogeneous mass with high signal intensity (arrow). (C) Sagittal T2-weighted image could not show clear delineation between the tumor and the prostate (arrow).

Mentions: A 76-year-old man suffered from constipation for 6 months. At the age of 26 years, he had undergone an appendectomy. The family history of the patient was unremarkable. He visited a local hospital where digital examination revealed a tumor with a hard, elastic and smooth surface in the anterior wall of the rectum at about 4 cm above the dentate line. Magnetic resonance imaging (MRI) showed a mass with a smooth margin, 7 cm × 5 cm in size mainly occupying the anterior wall of the lower rectum (Fig. 1). These findings suggested a GIST or rectal carcinoid originating from the rectal wall. The biopsy was avoided for the risk of intra-abdominal seeding or tumor rupture. Then he was referred to our hospital for further examination and treatment. Laboratory examination was unremarkable. Colonoscopy revealed an irregular tumor in the rectosigmoid colon approximately 15 cm from the anal verge, aside from the pelvic tumor, and biopsy of the tumor demonstrated moderately differentiated adenocarcinoma. However, no visible mucosal abnormality relevant to the pelvic tumor was found. Contrast-enhanced computed tomography (CT) showed an irregular circumferential mural thickening involving the rectosigmoid colon with no enlarged lymph nodes and a solitary irregular and low-density mass in the lower rectum extending from the anterior rectal wall into the prostate. No distant metastasis including the liver was found.


Large gastrointestinal stromal tumor and advanced adenocarcinoma in the rectum coexistent with an incidental prostate carcinoma: A case report.

Suzuki T, Suwa K, Hanyu K, Okamoto T, Fujita T, Yanaga K - Int J Surg Case Rep (2014)

Magnetic resonance imaging. (A) Transverse T1-weighted image showing a homogeneous mass with intermediate signal intensity (arrow). (B) Transverse T2-weighted image showing a heterogeneous mass with high signal intensity (arrow). (C) Sagittal T2-weighted image could not show clear delineation between the tumor and the prostate (arrow).
© Copyright Policy - CC BY-NC-ND
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4200885&req=5

fig0005: Magnetic resonance imaging. (A) Transverse T1-weighted image showing a homogeneous mass with intermediate signal intensity (arrow). (B) Transverse T2-weighted image showing a heterogeneous mass with high signal intensity (arrow). (C) Sagittal T2-weighted image could not show clear delineation between the tumor and the prostate (arrow).
Mentions: A 76-year-old man suffered from constipation for 6 months. At the age of 26 years, he had undergone an appendectomy. The family history of the patient was unremarkable. He visited a local hospital where digital examination revealed a tumor with a hard, elastic and smooth surface in the anterior wall of the rectum at about 4 cm above the dentate line. Magnetic resonance imaging (MRI) showed a mass with a smooth margin, 7 cm × 5 cm in size mainly occupying the anterior wall of the lower rectum (Fig. 1). These findings suggested a GIST or rectal carcinoid originating from the rectal wall. The biopsy was avoided for the risk of intra-abdominal seeding or tumor rupture. Then he was referred to our hospital for further examination and treatment. Laboratory examination was unremarkable. Colonoscopy revealed an irregular tumor in the rectosigmoid colon approximately 15 cm from the anal verge, aside from the pelvic tumor, and biopsy of the tumor demonstrated moderately differentiated adenocarcinoma. However, no visible mucosal abnormality relevant to the pelvic tumor was found. Contrast-enhanced computed tomography (CT) showed an irregular circumferential mural thickening involving the rectosigmoid colon with no enlarged lymph nodes and a solitary irregular and low-density mass in the lower rectum extending from the anterior rectal wall into the prostate. No distant metastasis including the liver was found.

Bottom Line: We herein describe a 76-year-old man with a large gastrointestinal stromal tumor along with an advanced adenocarcinoma in the rectum that coexisted with prostate carcinoma.The patient was given adjuvant chemotherapy with imatinib and remains disease-free as of 12 months after surgery.Radical surgery with perioperative adjuvant chemotherapy using tyrosine kinase inhibitors is the choice for treatment of large GISTs with a malignant potential.

View Article: PubMed Central - PubMed

Affiliation: Department of Surgery, The Jikei University, Daisan Hospital, Japan. Electronic address: toshiaki1129jp@yahoo.co.jp.

No MeSH data available.


Related in: MedlinePlus