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Synthesis, characterization and in vitro evaluation of new composite bisphosphonate delivery systems.

Kolmas J, Sobczak M, Olędzka E, Nałęcz-Jawecki G, Dębek C - Int J Mol Sci (2014)

Bottom Line: Next, composite drug delivery systems for clodronate were prepared.The mechanical properties of the obtained biomaterials were determined.The preliminary results show that the obtained composites are perspective biomaterials and they can be potentially applied in the technology of implantation drug delivery systems.

View Article: PubMed Central - PubMed

Affiliation: Department of Inorganic and Analytical Chemistry, Faculty of Pharmacy, Medical University of Warsaw, ul. Banacha 1, 02-097 Warsaw, Poland. joanna.kolmas@wp.pl.

ABSTRACT
In this study, new composite bisphosphonate delivery systems were obtained from polyurethanes (PUs) and nanocrystalline hydroxyapatite (HA). The biodegradable PUs were first synthesized from poly(ε-caprolactone) diols (PCL diols), poly(ethylene adipate) diol, 1,6-hexamethylene diisocyanate, 1,4-butanediol and HA. Moreover, the PCL diols were synthesized by the ring-opening polymerization catalysed by the lipase from Candida antarctica. Next, composite drug delivery systems for clodronate were prepared. The mechanical properties of the obtained biomaterials were determined. The cytotoxicity of the synthesized polymers was tested. The preliminary results show that the obtained composites are perspective biomaterials and they can be potentially applied in the technology of implantation drug delivery systems.

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Transmission electron microscope (TEM) image of the hydroxyapatite used as components of the composites.
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ijms-15-16831-f005: Transmission electron microscope (TEM) image of the hydroxyapatite used as components of the composites.

Mentions: The polyurethane/hydroxyapatite composites (PU-HA composites) were obtained from previously synthesized PU-1, PU-2 and PU-3 (Table 2). The ratio of PU to HA was 9:1 or 8:2 (w/w) (Figure 4). The composites were formed by mixing the mixture of PU and nanocrystalline HA with NaCl. The size of the HA crystals used varied from 15 to 40 nm (Figure 5).


Synthesis, characterization and in vitro evaluation of new composite bisphosphonate delivery systems.

Kolmas J, Sobczak M, Olędzka E, Nałęcz-Jawecki G, Dębek C - Int J Mol Sci (2014)

Transmission electron microscope (TEM) image of the hydroxyapatite used as components of the composites.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4200869&req=5

ijms-15-16831-f005: Transmission electron microscope (TEM) image of the hydroxyapatite used as components of the composites.
Mentions: The polyurethane/hydroxyapatite composites (PU-HA composites) were obtained from previously synthesized PU-1, PU-2 and PU-3 (Table 2). The ratio of PU to HA was 9:1 or 8:2 (w/w) (Figure 4). The composites were formed by mixing the mixture of PU and nanocrystalline HA with NaCl. The size of the HA crystals used varied from 15 to 40 nm (Figure 5).

Bottom Line: Next, composite drug delivery systems for clodronate were prepared.The mechanical properties of the obtained biomaterials were determined.The preliminary results show that the obtained composites are perspective biomaterials and they can be potentially applied in the technology of implantation drug delivery systems.

View Article: PubMed Central - PubMed

Affiliation: Department of Inorganic and Analytical Chemistry, Faculty of Pharmacy, Medical University of Warsaw, ul. Banacha 1, 02-097 Warsaw, Poland. joanna.kolmas@wp.pl.

ABSTRACT
In this study, new composite bisphosphonate delivery systems were obtained from polyurethanes (PUs) and nanocrystalline hydroxyapatite (HA). The biodegradable PUs were first synthesized from poly(ε-caprolactone) diols (PCL diols), poly(ethylene adipate) diol, 1,6-hexamethylene diisocyanate, 1,4-butanediol and HA. Moreover, the PCL diols were synthesized by the ring-opening polymerization catalysed by the lipase from Candida antarctica. Next, composite drug delivery systems for clodronate were prepared. The mechanical properties of the obtained biomaterials were determined. The cytotoxicity of the synthesized polymers was tested. The preliminary results show that the obtained composites are perspective biomaterials and they can be potentially applied in the technology of implantation drug delivery systems.

Show MeSH
Related in: MedlinePlus