Limits...
Cyclophosphamide-induced symptomatic hyponatremia, a rare but severe side effect: a case report.

Elazzazy S, Mohamed AE, Gulied A - Onco Targets Ther (2014)

Bottom Line: Cyclophosphamide is commonly used in the treatment of malignant diseases.Her laboratory test showed serum Na of 112 mmol/L.She completely recovered without neurological deficits after slow correction of the serum Na concentration.

View Article: PubMed Central - PubMed

Affiliation: Pharmacy Department, National Center for Cancer Care and Research (NCCCR), Hamad Medical Corporation, Doha, Qatar.

ABSTRACT
Cyclophosphamide is commonly used in the treatment of malignant diseases. Symptomatic severe hyponatremia induced by low-dose cyclophosphamide is very uncommon worldwide. We report a case of severe symptomatic hyponatremia that developed in a female breast cancer patient following the first cycle of chemotherapy containing low-dose cyclophosphamide. Her laboratory test showed serum Na of 112 mmol/L. Her hyponatremia was initially treated with sodium bicarbonate. She completely recovered without neurological deficits after slow correction of the serum Na concentration. Although hyponatremia is a rare toxicity it should always be considered during the usage of cyclophosphamide, even if the dosage is low, especially with concurrent use of other medications that impair water excretion, like chlorthalidone. This report describes the first reported case of cyclophosphamide-induced hyponatremia in Qatar.

No MeSH data available.


Related in: MedlinePlus

Cumulative summary report of serum Na level.
© Copyright Policy
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4199821&req=5

f1-ott-7-1641: Cumulative summary report of serum Na level.

Mentions: It was decided that the rest of chemotherapy was to be given under direct supervision as an inpatient. She was admitted for the second cycle on March 28, 2013. On day 1 of Cycle 2; the patient’s serum Na level was 142 mmol/L (prechemotherapy). On day 2, serum Na dropped to 127 mmol/L, and the patient was started on oral sodium chloride and IV sodium bicarbonate. Serum Na levels improved to reach 140 mmol/L on March 30, 2013 (day 3), and she was discharged home on March 31, 2013 (Figure 1).


Cyclophosphamide-induced symptomatic hyponatremia, a rare but severe side effect: a case report.

Elazzazy S, Mohamed AE, Gulied A - Onco Targets Ther (2014)

Cumulative summary report of serum Na level.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4199821&req=5

f1-ott-7-1641: Cumulative summary report of serum Na level.
Mentions: It was decided that the rest of chemotherapy was to be given under direct supervision as an inpatient. She was admitted for the second cycle on March 28, 2013. On day 1 of Cycle 2; the patient’s serum Na level was 142 mmol/L (prechemotherapy). On day 2, serum Na dropped to 127 mmol/L, and the patient was started on oral sodium chloride and IV sodium bicarbonate. Serum Na levels improved to reach 140 mmol/L on March 30, 2013 (day 3), and she was discharged home on March 31, 2013 (Figure 1).

Bottom Line: Cyclophosphamide is commonly used in the treatment of malignant diseases.Her laboratory test showed serum Na of 112 mmol/L.She completely recovered without neurological deficits after slow correction of the serum Na concentration.

View Article: PubMed Central - PubMed

Affiliation: Pharmacy Department, National Center for Cancer Care and Research (NCCCR), Hamad Medical Corporation, Doha, Qatar.

ABSTRACT
Cyclophosphamide is commonly used in the treatment of malignant diseases. Symptomatic severe hyponatremia induced by low-dose cyclophosphamide is very uncommon worldwide. We report a case of severe symptomatic hyponatremia that developed in a female breast cancer patient following the first cycle of chemotherapy containing low-dose cyclophosphamide. Her laboratory test showed serum Na of 112 mmol/L. Her hyponatremia was initially treated with sodium bicarbonate. She completely recovered without neurological deficits after slow correction of the serum Na concentration. Although hyponatremia is a rare toxicity it should always be considered during the usage of cyclophosphamide, even if the dosage is low, especially with concurrent use of other medications that impair water excretion, like chlorthalidone. This report describes the first reported case of cyclophosphamide-induced hyponatremia in Qatar.

No MeSH data available.


Related in: MedlinePlus