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Prognostic value of preoperative absolute lymphocyte count in recurrent hepatocellular carcinoma following thermal ablation: a retrospective analysis.

Li X, Han Z, Cheng Z, Yu J, Yu X, Liang P - Onco Targets Ther (2014)

Bottom Line: ALC ≥1.64×10(9)/L defined by ROC calculation was associated with prolonged survival (area under the curve 0.741, P<0.001).After excluding the basic parameters between groups, the 1- and 3-year recurrence rates in the high group were 20.9% and 29.5%, respectively, which were significantly lower than those of the low group (58.4% and 71.9%, respectively; P<0.001).The recurrence-free survival rates in the two groups analyzed by Kaplan-Meier curves were significantly different (P<0.001).

View Article: PubMed Central - PubMed

Affiliation: Department of Interventional Ultrasound, Chinese PLA General Hospital, Beijing, People's Republic of China.

ABSTRACT

Purpose: To investigate the prognostic value of preoperative absolute lymphocyte count (ALC) in recurrent hepatocellular carcinoma (RHCC) following thermal ablation.

Materials and methods: We retrospectively analyzed the relationship between preoperative ALC and the clinicopathologic factors and long-term prognosis in 423 RHCC patients who underwent curative thermal ablation. Correlation analysis, receiver operating characteristic (ROC) calculation, Kaplan-Meier curves, and multivariate regression were used for statistical analysis.

Results: The median time to recurrence was 12 months for RHCC patients after thermal ablation. On multivariate Cox regression analysis, preoperative ALC was an independent risk factor for cancer recurrence, along with tumor differentiation and α-fetoprotein level. ALC ≥1.64×10(9)/L defined by ROC calculation was associated with prolonged survival (area under the curve 0.741, P<0.001). Patients with ALC ≥1.64×10(9)/L showed a mean survival of 20.2 months versus 11.6 months for patients with ALC <1.64×10(9)/L (P<0.001). Patients were stratified into high and low groups according to ALC status. After excluding the basic parameters between groups, the 1- and 3-year recurrence rates in the high group were 20.9% and 29.5%, respectively, which were significantly lower than those of the low group (58.4% and 71.9%, respectively; P<0.001). The recurrence-free survival rates in the two groups analyzed by Kaplan-Meier curves were significantly different (P<0.001).

Conclusion: Preoperative ALC is a powerful prognostic factor for RHCC recurrence after thermal ablation, which suggests that maintaining a high ALC in RHCC patients might improve cancer outcomes.

No MeSH data available.


Related in: MedlinePlus

Receive-operating characteristic curve (ROC) analysis for ALC predicts recurrence in RHCC patients following thermal ablation.Notes: ALC ≥1.64×109/L was determined to be the cutoff value (AUROC =0.741, P<0.001). Diagonal segments are produced by ties.Abbreviations: ALC, absolute lymphocyte count; RHCC, recurrent hepatocellular carcinoma; AUROC, area under the ROC.
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f1-ott-7-1829: Receive-operating characteristic curve (ROC) analysis for ALC predicts recurrence in RHCC patients following thermal ablation.Notes: ALC ≥1.64×109/L was determined to be the cutoff value (AUROC =0.741, P<0.001). Diagonal segments are produced by ties.Abbreviations: ALC, absolute lymphocyte count; RHCC, recurrent hepatocellular carcinoma; AUROC, area under the ROC.

Mentions: To analyze the predicted value of ALC for cancer recurrence in RHCC patients following thermal ablation, a time-dependent ROC curve was generated. An ALC of 1.64×109/L was the best cutoff point for predicting recurrence after thermal ablation in RHCC patients (area under the ROC was 0.741, P<0.001; Figure 1). We therefore utilized an ALC cutoff of 1.64×109/L as a risk factor for RHCC recurrence. All patients were divided into one of two groups: a low (<1.64×109/L)-ALC group (n=293, 69.3%) and a high (≥1.64×109/L)-ALC group (n=130, 30.7%). This result further indicates that the majority of RHCC patients had impaired immunity status, which may reduce the antitumor capabilities of RHCC patients and may be the basis of their greater inclination for recurrence.


Prognostic value of preoperative absolute lymphocyte count in recurrent hepatocellular carcinoma following thermal ablation: a retrospective analysis.

Li X, Han Z, Cheng Z, Yu J, Yu X, Liang P - Onco Targets Ther (2014)

Receive-operating characteristic curve (ROC) analysis for ALC predicts recurrence in RHCC patients following thermal ablation.Notes: ALC ≥1.64×109/L was determined to be the cutoff value (AUROC =0.741, P<0.001). Diagonal segments are produced by ties.Abbreviations: ALC, absolute lymphocyte count; RHCC, recurrent hepatocellular carcinoma; AUROC, area under the ROC.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4199816&req=5

f1-ott-7-1829: Receive-operating characteristic curve (ROC) analysis for ALC predicts recurrence in RHCC patients following thermal ablation.Notes: ALC ≥1.64×109/L was determined to be the cutoff value (AUROC =0.741, P<0.001). Diagonal segments are produced by ties.Abbreviations: ALC, absolute lymphocyte count; RHCC, recurrent hepatocellular carcinoma; AUROC, area under the ROC.
Mentions: To analyze the predicted value of ALC for cancer recurrence in RHCC patients following thermal ablation, a time-dependent ROC curve was generated. An ALC of 1.64×109/L was the best cutoff point for predicting recurrence after thermal ablation in RHCC patients (area under the ROC was 0.741, P<0.001; Figure 1). We therefore utilized an ALC cutoff of 1.64×109/L as a risk factor for RHCC recurrence. All patients were divided into one of two groups: a low (<1.64×109/L)-ALC group (n=293, 69.3%) and a high (≥1.64×109/L)-ALC group (n=130, 30.7%). This result further indicates that the majority of RHCC patients had impaired immunity status, which may reduce the antitumor capabilities of RHCC patients and may be the basis of their greater inclination for recurrence.

Bottom Line: ALC ≥1.64×10(9)/L defined by ROC calculation was associated with prolonged survival (area under the curve 0.741, P<0.001).After excluding the basic parameters between groups, the 1- and 3-year recurrence rates in the high group were 20.9% and 29.5%, respectively, which were significantly lower than those of the low group (58.4% and 71.9%, respectively; P<0.001).The recurrence-free survival rates in the two groups analyzed by Kaplan-Meier curves were significantly different (P<0.001).

View Article: PubMed Central - PubMed

Affiliation: Department of Interventional Ultrasound, Chinese PLA General Hospital, Beijing, People's Republic of China.

ABSTRACT

Purpose: To investigate the prognostic value of preoperative absolute lymphocyte count (ALC) in recurrent hepatocellular carcinoma (RHCC) following thermal ablation.

Materials and methods: We retrospectively analyzed the relationship between preoperative ALC and the clinicopathologic factors and long-term prognosis in 423 RHCC patients who underwent curative thermal ablation. Correlation analysis, receiver operating characteristic (ROC) calculation, Kaplan-Meier curves, and multivariate regression were used for statistical analysis.

Results: The median time to recurrence was 12 months for RHCC patients after thermal ablation. On multivariate Cox regression analysis, preoperative ALC was an independent risk factor for cancer recurrence, along with tumor differentiation and α-fetoprotein level. ALC ≥1.64×10(9)/L defined by ROC calculation was associated with prolonged survival (area under the curve 0.741, P<0.001). Patients with ALC ≥1.64×10(9)/L showed a mean survival of 20.2 months versus 11.6 months for patients with ALC <1.64×10(9)/L (P<0.001). Patients were stratified into high and low groups according to ALC status. After excluding the basic parameters between groups, the 1- and 3-year recurrence rates in the high group were 20.9% and 29.5%, respectively, which were significantly lower than those of the low group (58.4% and 71.9%, respectively; P<0.001). The recurrence-free survival rates in the two groups analyzed by Kaplan-Meier curves were significantly different (P<0.001).

Conclusion: Preoperative ALC is a powerful prognostic factor for RHCC recurrence after thermal ablation, which suggests that maintaining a high ALC in RHCC patients might improve cancer outcomes.

No MeSH data available.


Related in: MedlinePlus