Limits...
Facile synthesis of folate-conjugated magnetic/fluorescent bifunctional microspheres.

Shen M, Jia W, Lin C, Fan G, Jin Y, Chen X, Chen G - Nanoscale Res Lett (2014)

Bottom Line: The preparation procedure included the preparation of chitosan-coated Fe3O4 nanoparticles (CS-coated Fe3O4 NPs) prepared by a one-pot solvothermal method, the reaction between carboxylic and amino groups under activation of NHS and EDC in order to obtain the CdTe-CS-coated Fe3O4 NPs, and finally the growth of SiO2 shell vent the photoluminescence (PL) quenching via a Stöber method (Fe3O4-CdTe@SiO2).Moreover, in order to have a specific targeting capacity, the magnetic and fluorescent bifunctional microspheres were synthesized by bonding of SiO2 shell with FA molecules via amide reaction (Fe3O4-CdTe@SiO2-FA).The morphology, size, chemical components, and magnetic property of as-prepared composite nanoparticles were characterized by ultraviolet-visible spectroscopy, fluorescent spectroscopy, Fourier transform infrared spectroscopy (FTIR), X-ray powder diffraction (XRD), scanning transmission electron microscopy (SEM), transmission electron microscopy (TEM), thermogravimetric analysis (TGA), and vibrating sample magnetometer (VSM), respectively.

View Article: PubMed Central - HTML - PubMed

Affiliation: College of Pharmaceutical and Chemical Engineering, Taizhou University, Jiaojiang 318000, People's Republic of China.

ABSTRACT
In this paper, we investigated the functional imaging properties of magnetic microspheres composed of magnetic core and CdTe quantum dots in the silica shell functionalized with folic acid (FA). The preparation procedure included the preparation of chitosan-coated Fe3O4 nanoparticles (CS-coated Fe3O4 NPs) prepared by a one-pot solvothermal method, the reaction between carboxylic and amino groups under activation of NHS and EDC in order to obtain the CdTe-CS-coated Fe3O4 NPs, and finally the growth of SiO2 shell vent the photoluminescence (PL) quenching via a Stöber method (Fe3O4-CdTe@SiO2). Moreover, in order to have a specific targeting capacity, the magnetic and fluorescent bifunctional microspheres were synthesized by bonding of SiO2 shell with FA molecules via amide reaction (Fe3O4-CdTe@SiO2-FA). The morphology, size, chemical components, and magnetic property of as-prepared composite nanoparticles were characterized by ultraviolet-visible spectroscopy, fluorescent spectroscopy, Fourier transform infrared spectroscopy (FTIR), X-ray powder diffraction (XRD), scanning transmission electron microscopy (SEM), transmission electron microscopy (TEM), thermogravimetric analysis (TGA), and vibrating sample magnetometer (VSM), respectively. The results show that the magnetic and fluorescent bifunctional microspheres have strong luminescent which will be employed for immuno-labeling and fluorescent imaging of HeLa cells.

No MeSH data available.


TGA curves of (a) naked Fe3O4 NPs and (b) CS-coated Fe3O4 NPs.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4199784&req=5

Figure 5: TGA curves of (a) naked Fe3O4 NPs and (b) CS-coated Fe3O4 NPs.

Mentions: The TGA curves of naked Fe3O4, and CS-coated Fe3O4 NPs were shown in Figure 5. For naked Fe3O4, the TGA curve shows that the weight loss over the temperature range from 100 to 800°C was about 6.4%. This might be due to the loss of the removal of the remaining water and agents. Comparing with the TGA curves of the naked Fe3O4 NPs, the CS-coated Fe3O4 NPs show that the main mass of the as-synthesized occurred about 37.5% decreasing attributed to the decomposition of CS anchored on the surface of the Fe3O4 NPs.


Facile synthesis of folate-conjugated magnetic/fluorescent bifunctional microspheres.

Shen M, Jia W, Lin C, Fan G, Jin Y, Chen X, Chen G - Nanoscale Res Lett (2014)

TGA curves of (a) naked Fe3O4 NPs and (b) CS-coated Fe3O4 NPs.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4199784&req=5

Figure 5: TGA curves of (a) naked Fe3O4 NPs and (b) CS-coated Fe3O4 NPs.
Mentions: The TGA curves of naked Fe3O4, and CS-coated Fe3O4 NPs were shown in Figure 5. For naked Fe3O4, the TGA curve shows that the weight loss over the temperature range from 100 to 800°C was about 6.4%. This might be due to the loss of the removal of the remaining water and agents. Comparing with the TGA curves of the naked Fe3O4 NPs, the CS-coated Fe3O4 NPs show that the main mass of the as-synthesized occurred about 37.5% decreasing attributed to the decomposition of CS anchored on the surface of the Fe3O4 NPs.

Bottom Line: The preparation procedure included the preparation of chitosan-coated Fe3O4 nanoparticles (CS-coated Fe3O4 NPs) prepared by a one-pot solvothermal method, the reaction between carboxylic and amino groups under activation of NHS and EDC in order to obtain the CdTe-CS-coated Fe3O4 NPs, and finally the growth of SiO2 shell vent the photoluminescence (PL) quenching via a Stöber method (Fe3O4-CdTe@SiO2).Moreover, in order to have a specific targeting capacity, the magnetic and fluorescent bifunctional microspheres were synthesized by bonding of SiO2 shell with FA molecules via amide reaction (Fe3O4-CdTe@SiO2-FA).The morphology, size, chemical components, and magnetic property of as-prepared composite nanoparticles were characterized by ultraviolet-visible spectroscopy, fluorescent spectroscopy, Fourier transform infrared spectroscopy (FTIR), X-ray powder diffraction (XRD), scanning transmission electron microscopy (SEM), transmission electron microscopy (TEM), thermogravimetric analysis (TGA), and vibrating sample magnetometer (VSM), respectively.

View Article: PubMed Central - HTML - PubMed

Affiliation: College of Pharmaceutical and Chemical Engineering, Taizhou University, Jiaojiang 318000, People's Republic of China.

ABSTRACT
In this paper, we investigated the functional imaging properties of magnetic microspheres composed of magnetic core and CdTe quantum dots in the silica shell functionalized with folic acid (FA). The preparation procedure included the preparation of chitosan-coated Fe3O4 nanoparticles (CS-coated Fe3O4 NPs) prepared by a one-pot solvothermal method, the reaction between carboxylic and amino groups under activation of NHS and EDC in order to obtain the CdTe-CS-coated Fe3O4 NPs, and finally the growth of SiO2 shell vent the photoluminescence (PL) quenching via a Stöber method (Fe3O4-CdTe@SiO2). Moreover, in order to have a specific targeting capacity, the magnetic and fluorescent bifunctional microspheres were synthesized by bonding of SiO2 shell with FA molecules via amide reaction (Fe3O4-CdTe@SiO2-FA). The morphology, size, chemical components, and magnetic property of as-prepared composite nanoparticles were characterized by ultraviolet-visible spectroscopy, fluorescent spectroscopy, Fourier transform infrared spectroscopy (FTIR), X-ray powder diffraction (XRD), scanning transmission electron microscopy (SEM), transmission electron microscopy (TEM), thermogravimetric analysis (TGA), and vibrating sample magnetometer (VSM), respectively. The results show that the magnetic and fluorescent bifunctional microspheres have strong luminescent which will be employed for immuno-labeling and fluorescent imaging of HeLa cells.

No MeSH data available.