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Vitreous and plasma VEGF levels as predictive factors in the progression of proliferative diabetic retinopathy after vitrectomy.

Wang J, Chen S, Jiang F, You C, Mao C, Yu J, Han J, Zhang Z, Yan H - PLoS ONE (2014)

Bottom Line: VEGF levels and clinical data were compared and analyzed to see if they provide a prognosis of PDR progression after primary vitrectomy at more than 6 months follow-up.The average BCVA was significantly improved after surgery (P<0.001).The increased VEGF level in vitreous fluid may be identified as a significant predictive factor for the outcome of vitrectomy in patients with PDR.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Tianjin Medical University General Hospital, Tianjin, China.

ABSTRACT

Purpose: To investigate the vitreous and plasma levels of vascular endothelial growth factor (VEGF) in patients with proliferative diabetic retinopathy (PDR) and to determine whether they predict a disease prognosis after primary vitrectomy.

Methods: Fifty patients (50 eyes) with PDR who underwent pars plana vitrectomy (PPV) and 56 healthy controls (56 eyes) were enrolled in this retrospective study. Clinical data were collected and analyzed. Vitreous and plasma VEGF concentrations were measured using enzyme-linked immunosorbent assays. VEGF levels and clinical data were compared and analyzed to see if they provide a prognosis of PDR progression after primary vitrectomy at more than 6 months follow-up. Correlation of VEGF concentrations between vitreous fluid and plasma was analyzed.

Results: The average BCVA was significantly improved after surgery (P<0.001). Vitreous and plasma VEGF levels were significantly elevated in PDR patients than those in healthy controls (P vitreous<0.001; P plasma<0.001). Both vitreous and plasma VEGF levels were significantly higher in PDR progression group than in stable group (P vitreous < 0.001; P plasma = 0.004). Multivariate logistic regression analyses showed that the increased vitreous VEGF level was associated with the progression of PDR after primary PPV (OR = 1.539; P = 0.036). Vitreous VEGF level was positively associated with plasma VEGF level in PDR patients (P<0.001).

Conclusion: The increased VEGF level in vitreous fluid may be identified as a significant predictive factor for the outcome of vitrectomy in patients with PDR.

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Related in: MedlinePlus

Comparison of vitreous and plasma VEGF concentration in PDR patients and Healthy controls, respectively.Gray bars on the left: Vitreous VEGF concentrations were significantly higher in PDR patients than in healthy controls (P<0.001); White bars on the right: Plasma VEGF concentrations were significantly higher in PDR patients than in healthy controls (P<0.001). Note: In the box plot (Figure 1 and 3,), the horizontal line in the box means the Median; the box means Interquartile range(IQR), i.e. the range of upper quartile(Q3) and lower quartile(Q1); the highest means the Q3+1.5IQR and lowest line means Q1-1.5IQR; the white circle means mild outlier and the asterisk means extreme outlier.
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pone-0110531-g001: Comparison of vitreous and plasma VEGF concentration in PDR patients and Healthy controls, respectively.Gray bars on the left: Vitreous VEGF concentrations were significantly higher in PDR patients than in healthy controls (P<0.001); White bars on the right: Plasma VEGF concentrations were significantly higher in PDR patients than in healthy controls (P<0.001). Note: In the box plot (Figure 1 and 3,), the horizontal line in the box means the Median; the box means Interquartile range(IQR), i.e. the range of upper quartile(Q3) and lower quartile(Q1); the highest means the Q3+1.5IQR and lowest line means Q1-1.5IQR; the white circle means mild outlier and the asterisk means extreme outlier.

Mentions: The vitreous VEGF concentration was 585.67±257.40pg/mL in the PDR patients and 123.85±109.42pg/mL in healthy controls. The plasma VEGF concentration was 410.07±174.70pg/mL in the PDR patients and 114.41±110.99pg/mL in healthy controls. Both plasma and vitreous VEGF levels were shown significantly higher in PDR patients than in healthy controls (tplasma = 10.512, Pplasma<0.001; tvitreous = 12.249, Pvitreous<0.001) (Table 2, Figure 1).


Vitreous and plasma VEGF levels as predictive factors in the progression of proliferative diabetic retinopathy after vitrectomy.

Wang J, Chen S, Jiang F, You C, Mao C, Yu J, Han J, Zhang Z, Yan H - PLoS ONE (2014)

Comparison of vitreous and plasma VEGF concentration in PDR patients and Healthy controls, respectively.Gray bars on the left: Vitreous VEGF concentrations were significantly higher in PDR patients than in healthy controls (P<0.001); White bars on the right: Plasma VEGF concentrations were significantly higher in PDR patients than in healthy controls (P<0.001). Note: In the box plot (Figure 1 and 3,), the horizontal line in the box means the Median; the box means Interquartile range(IQR), i.e. the range of upper quartile(Q3) and lower quartile(Q1); the highest means the Q3+1.5IQR and lowest line means Q1-1.5IQR; the white circle means mild outlier and the asterisk means extreme outlier.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4199758&req=5

pone-0110531-g001: Comparison of vitreous and plasma VEGF concentration in PDR patients and Healthy controls, respectively.Gray bars on the left: Vitreous VEGF concentrations were significantly higher in PDR patients than in healthy controls (P<0.001); White bars on the right: Plasma VEGF concentrations were significantly higher in PDR patients than in healthy controls (P<0.001). Note: In the box plot (Figure 1 and 3,), the horizontal line in the box means the Median; the box means Interquartile range(IQR), i.e. the range of upper quartile(Q3) and lower quartile(Q1); the highest means the Q3+1.5IQR and lowest line means Q1-1.5IQR; the white circle means mild outlier and the asterisk means extreme outlier.
Mentions: The vitreous VEGF concentration was 585.67±257.40pg/mL in the PDR patients and 123.85±109.42pg/mL in healthy controls. The plasma VEGF concentration was 410.07±174.70pg/mL in the PDR patients and 114.41±110.99pg/mL in healthy controls. Both plasma and vitreous VEGF levels were shown significantly higher in PDR patients than in healthy controls (tplasma = 10.512, Pplasma<0.001; tvitreous = 12.249, Pvitreous<0.001) (Table 2, Figure 1).

Bottom Line: VEGF levels and clinical data were compared and analyzed to see if they provide a prognosis of PDR progression after primary vitrectomy at more than 6 months follow-up.The average BCVA was significantly improved after surgery (P<0.001).The increased VEGF level in vitreous fluid may be identified as a significant predictive factor for the outcome of vitrectomy in patients with PDR.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Tianjin Medical University General Hospital, Tianjin, China.

ABSTRACT

Purpose: To investigate the vitreous and plasma levels of vascular endothelial growth factor (VEGF) in patients with proliferative diabetic retinopathy (PDR) and to determine whether they predict a disease prognosis after primary vitrectomy.

Methods: Fifty patients (50 eyes) with PDR who underwent pars plana vitrectomy (PPV) and 56 healthy controls (56 eyes) were enrolled in this retrospective study. Clinical data were collected and analyzed. Vitreous and plasma VEGF concentrations were measured using enzyme-linked immunosorbent assays. VEGF levels and clinical data were compared and analyzed to see if they provide a prognosis of PDR progression after primary vitrectomy at more than 6 months follow-up. Correlation of VEGF concentrations between vitreous fluid and plasma was analyzed.

Results: The average BCVA was significantly improved after surgery (P<0.001). Vitreous and plasma VEGF levels were significantly elevated in PDR patients than those in healthy controls (P vitreous<0.001; P plasma<0.001). Both vitreous and plasma VEGF levels were significantly higher in PDR progression group than in stable group (P vitreous < 0.001; P plasma = 0.004). Multivariate logistic regression analyses showed that the increased vitreous VEGF level was associated with the progression of PDR after primary PPV (OR = 1.539; P = 0.036). Vitreous VEGF level was positively associated with plasma VEGF level in PDR patients (P<0.001).

Conclusion: The increased VEGF level in vitreous fluid may be identified as a significant predictive factor for the outcome of vitrectomy in patients with PDR.

Show MeSH
Related in: MedlinePlus