Sensory rewiring in an echolocator: genome-wide modification of retinogenic and auditory genes in the bat Myotis davidii.
Bottom Line: Using the naked mole rat as a reference, we found five functional genes (CYP1A2, RBP3, GUCY2F, CRYBB1, and GRK7) encoding visual proteins that have degenerated into pseudogenes in M. davidii but not P. alecto.In a second approach genome-wide codon usage bias (CUB) was compared between the two bat species.Together, they help explain how natural selection has reduced physiological costs associated with the development of a smaller eye poorly adapted to day vision but that also contribute to enhanced dim light vision and the hearing adaptations consonant with echolocation.
Affiliation: Computational and Systems Biology, CSIRO Agriculture Flagship, Queensland Bioscience Precinct, Brisbane, Queensland, Australia firstname.lastname@example.org.Show MeSH
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Mentions: We calculated codon usage preferences for the two species genome-wide (Table 2 and Table 3). These genome-wide figures can be used to help establish preferred and nonpreferred codons for that particular species in concert with the available tRNA pool. In turn this helps shed light on the translational implications of CUB. Namely, is CUB likely to increase or decrease the energetic cost and efficiency of translation for the gene in question?
Affiliation: Computational and Systems Biology, CSIRO Agriculture Flagship, Queensland Bioscience Precinct, Brisbane, Queensland, Australia email@example.com.