Widespread genomic incompatibilities in Caenorhabditis elegans.
Bottom Line: For two of the QTL regions, results are inconsistent with a model of pairwise interaction between two loci, suggesting that the incompatibilities are a consequence of complex interactions between multiple loci.Analysis of additional life history traits indicates that the QTL regions identified in these screens are associated with effects on other traits such as lifespan and reproduction, suggesting that the incompatibilities are likely to be deleterious.Taken together, these results indicate that numerous BDM incompatibilities that could contribute to reproductive isolation can be detected and mapped within C. elegans.
Affiliation: Laboratory of Nematology, Wageningen University, 6708 PB Wageningen, The Netherlands.Show MeSH
Related in: MedlinePlus
Mentions: Preliminary experiments and the RIL and IL analyses indicated that N2 and CB4856 lay the majority of their eggs at very early stages of development. To investigate natural variation in this trait more broadly, we assayed, as described previously, a range of wild isolates. The IL ewIR51, which contains a CB4856 introgression on chromosome IV that results in the production of large numbers of late stage progeny (see Figure 2 and Figure S2), was included in these assays as a control.
Affiliation: Laboratory of Nematology, Wageningen University, 6708 PB Wageningen, The Netherlands.