Limits...
The Effect of Acetyl Salicylic Acid Induced Nitric Oxide Synthesis in the Normalization of Hypertension through the Stimulation of Renal Cortexin Synthesis and by the Inhibition of Dermcidin Isoform 2, A Hypertensive Protein Production.

Ghosh R, Bank S, Maji UK, Bhattacharya R, Guha S, Khan NN, Sinha AK - Int J Biomed Sci (2014)

Bottom Line: The plasma cortexin level at day 0, 1, 30 and 90 were 0.5 pmol/ml, 155.5 pmol/ml, 160.2 pmol/ml, 190.5 pmol/ml respectively with increased NO synthesis (r=+0.994).In vitro studies demonstrated that the incubation of the goat kidney cortex cells with aspirin stimulated (r)-cortexin synthesis due to NO synthesis.It could be suggested that the use of aspirin might control EH in man.

View Article: PubMed Central - PubMed

Affiliation: Sinha Institute of Medical Science and Technology, Garia 700084, India;

ABSTRACT
Currently, there is no specific medication for essential hypertension (EH), a major form of the condition, in man. As acetyl salicylic acid (aspirin) is reported to stimulate the synthesis of renal (r)-cortexin, an anti-essential hypertensive protein, and, as aspirin is reported to inhibit dermcidin isoform 2 (dermcidin), a causative protein for EH, the role of aspirin in the control of EH in man was studied. Oral administration of 150 mg aspirin/70 kg body weight in subjects with EH was found to reduce both the elevated systolic and diastolic blood pressures to normal levels within 3 h due to the normalization of dermcidin level in these subjects. The plasma cortexin level at day 0, 1, 30 and 90 were 0.5 pmol/ml, 155.5 pmol/ml, 160.2 pmol/ml, 190.5 pmol/ml respectively with increased NO synthesis (r=+0.994). In vitro studies demonstrated that the incubation of the goat kidney cortex cells with aspirin stimulated (r)-cortexin synthesis due to NO synthesis. It could be suggested that the use of aspirin might control EH in man.

No MeSH data available.


Related in: MedlinePlus

Effect of ingestion of aspirin by hypertensive subjects for different times on Systolic Blood Pressure (SBP), Diastolic Blood Pressure (DBP), (r)-cortexin and NO levels. Hypertensive subjects (n=74; M=37, F=37) were asked to ingest 150 mg of aspirin as described in the Materials and Methods. These subjects continued aspirin ingestion every 24 h for 3 months. Both SBP and DBP were measured before and after the ingestion of the compound and the plasma NO and cortexin levels were also determined in these subjects. Solid bars () represent the Systolic Blood Pressure (SBP). Gray bars () represent the Diastolic Blood Pressure (DBP). Hollow bars (□) indicate the NO synthesis. Dotted bars () represent the (r)-cortexin synthesis. The results are mean ± S.D. of the participants (n=74) (p<0.05).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4199471&req=5

Figure 3: Effect of ingestion of aspirin by hypertensive subjects for different times on Systolic Blood Pressure (SBP), Diastolic Blood Pressure (DBP), (r)-cortexin and NO levels. Hypertensive subjects (n=74; M=37, F=37) were asked to ingest 150 mg of aspirin as described in the Materials and Methods. These subjects continued aspirin ingestion every 24 h for 3 months. Both SBP and DBP were measured before and after the ingestion of the compound and the plasma NO and cortexin levels were also determined in these subjects. Solid bars () represent the Systolic Blood Pressure (SBP). Gray bars () represent the Diastolic Blood Pressure (DBP). Hollow bars (□) indicate the NO synthesis. Dotted bars () represent the (r)-cortexin synthesis. The results are mean ± S.D. of the participants (n=74) (p<0.05).

Mentions: An equal number of age and gender matched subjects with EH who at their own wish did not receive aspirin, but had taken an adequate meal served as the controls. Both SBP and DBP were determined after 3 h in both these groups of subjects with or without the ingestion of aspirin and blood samples were again collected after 3 h from these subjects. The plasma cortexin level was also determined which was found to be increased from 0.5 pmol/ml to 110 pmol/ml in those subjects who has ingested aspirin. The experiment was extended for 90 days and SBP and DBP were determined along with the assay of plasma cortexin levels. After 24 h of ingestion of aspirin, the plasma cortexin level was 155.5 pmol/ml, and after 30 days the level of cortexin was found to be 160.2 pmol/ml with a reduction of both SBP and DBP to 135 ± 0.5 mm of Hg and 81.7 ± 3.4 mm of Hg respectively. The cortexin level after 90 days was 190.5 pmol/ml with increased NO synthesis (r=+0.994) (Fig. 3).


The Effect of Acetyl Salicylic Acid Induced Nitric Oxide Synthesis in the Normalization of Hypertension through the Stimulation of Renal Cortexin Synthesis and by the Inhibition of Dermcidin Isoform 2, A Hypertensive Protein Production.

Ghosh R, Bank S, Maji UK, Bhattacharya R, Guha S, Khan NN, Sinha AK - Int J Biomed Sci (2014)

Effect of ingestion of aspirin by hypertensive subjects for different times on Systolic Blood Pressure (SBP), Diastolic Blood Pressure (DBP), (r)-cortexin and NO levels. Hypertensive subjects (n=74; M=37, F=37) were asked to ingest 150 mg of aspirin as described in the Materials and Methods. These subjects continued aspirin ingestion every 24 h for 3 months. Both SBP and DBP were measured before and after the ingestion of the compound and the plasma NO and cortexin levels were also determined in these subjects. Solid bars () represent the Systolic Blood Pressure (SBP). Gray bars () represent the Diastolic Blood Pressure (DBP). Hollow bars (□) indicate the NO synthesis. Dotted bars () represent the (r)-cortexin synthesis. The results are mean ± S.D. of the participants (n=74) (p<0.05).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4199471&req=5

Figure 3: Effect of ingestion of aspirin by hypertensive subjects for different times on Systolic Blood Pressure (SBP), Diastolic Blood Pressure (DBP), (r)-cortexin and NO levels. Hypertensive subjects (n=74; M=37, F=37) were asked to ingest 150 mg of aspirin as described in the Materials and Methods. These subjects continued aspirin ingestion every 24 h for 3 months. Both SBP and DBP were measured before and after the ingestion of the compound and the plasma NO and cortexin levels were also determined in these subjects. Solid bars () represent the Systolic Blood Pressure (SBP). Gray bars () represent the Diastolic Blood Pressure (DBP). Hollow bars (□) indicate the NO synthesis. Dotted bars () represent the (r)-cortexin synthesis. The results are mean ± S.D. of the participants (n=74) (p<0.05).
Mentions: An equal number of age and gender matched subjects with EH who at their own wish did not receive aspirin, but had taken an adequate meal served as the controls. Both SBP and DBP were determined after 3 h in both these groups of subjects with or without the ingestion of aspirin and blood samples were again collected after 3 h from these subjects. The plasma cortexin level was also determined which was found to be increased from 0.5 pmol/ml to 110 pmol/ml in those subjects who has ingested aspirin. The experiment was extended for 90 days and SBP and DBP were determined along with the assay of plasma cortexin levels. After 24 h of ingestion of aspirin, the plasma cortexin level was 155.5 pmol/ml, and after 30 days the level of cortexin was found to be 160.2 pmol/ml with a reduction of both SBP and DBP to 135 ± 0.5 mm of Hg and 81.7 ± 3.4 mm of Hg respectively. The cortexin level after 90 days was 190.5 pmol/ml with increased NO synthesis (r=+0.994) (Fig. 3).

Bottom Line: The plasma cortexin level at day 0, 1, 30 and 90 were 0.5 pmol/ml, 155.5 pmol/ml, 160.2 pmol/ml, 190.5 pmol/ml respectively with increased NO synthesis (r=+0.994).In vitro studies demonstrated that the incubation of the goat kidney cortex cells with aspirin stimulated (r)-cortexin synthesis due to NO synthesis.It could be suggested that the use of aspirin might control EH in man.

View Article: PubMed Central - PubMed

Affiliation: Sinha Institute of Medical Science and Technology, Garia 700084, India;

ABSTRACT
Currently, there is no specific medication for essential hypertension (EH), a major form of the condition, in man. As acetyl salicylic acid (aspirin) is reported to stimulate the synthesis of renal (r)-cortexin, an anti-essential hypertensive protein, and, as aspirin is reported to inhibit dermcidin isoform 2 (dermcidin), a causative protein for EH, the role of aspirin in the control of EH in man was studied. Oral administration of 150 mg aspirin/70 kg body weight in subjects with EH was found to reduce both the elevated systolic and diastolic blood pressures to normal levels within 3 h due to the normalization of dermcidin level in these subjects. The plasma cortexin level at day 0, 1, 30 and 90 were 0.5 pmol/ml, 155.5 pmol/ml, 160.2 pmol/ml, 190.5 pmol/ml respectively with increased NO synthesis (r=+0.994). In vitro studies demonstrated that the incubation of the goat kidney cortex cells with aspirin stimulated (r)-cortexin synthesis due to NO synthesis. It could be suggested that the use of aspirin might control EH in man.

No MeSH data available.


Related in: MedlinePlus