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The Effect of Acetyl Salicylic Acid Induced Nitric Oxide Synthesis in the Normalization of Hypertension through the Stimulation of Renal Cortexin Synthesis and by the Inhibition of Dermcidin Isoform 2, A Hypertensive Protein Production.

Ghosh R, Bank S, Maji UK, Bhattacharya R, Guha S, Khan NN, Sinha AK - Int J Biomed Sci (2014)

Bottom Line: The plasma cortexin level at day 0, 1, 30 and 90 were 0.5 pmol/ml, 155.5 pmol/ml, 160.2 pmol/ml, 190.5 pmol/ml respectively with increased NO synthesis (r=+0.994).In vitro studies demonstrated that the incubation of the goat kidney cortex cells with aspirin stimulated (r)-cortexin synthesis due to NO synthesis.It could be suggested that the use of aspirin might control EH in man.

View Article: PubMed Central - PubMed

Affiliation: Sinha Institute of Medical Science and Technology, Garia 700084, India;

ABSTRACT
Currently, there is no specific medication for essential hypertension (EH), a major form of the condition, in man. As acetyl salicylic acid (aspirin) is reported to stimulate the synthesis of renal (r)-cortexin, an anti-essential hypertensive protein, and, as aspirin is reported to inhibit dermcidin isoform 2 (dermcidin), a causative protein for EH, the role of aspirin in the control of EH in man was studied. Oral administration of 150 mg aspirin/70 kg body weight in subjects with EH was found to reduce both the elevated systolic and diastolic blood pressures to normal levels within 3 h due to the normalization of dermcidin level in these subjects. The plasma cortexin level at day 0, 1, 30 and 90 were 0.5 pmol/ml, 155.5 pmol/ml, 160.2 pmol/ml, 190.5 pmol/ml respectively with increased NO synthesis (r=+0.994). In vitro studies demonstrated that the incubation of the goat kidney cortex cells with aspirin stimulated (r)-cortexin synthesis due to NO synthesis. It could be suggested that the use of aspirin might control EH in man.

No MeSH data available.


Related in: MedlinePlus

The effect of oral administration of aspirin on the elevated blood pressures after different periods of time. Seventy four hypertensive patients (n=74; M=37, F=37) were administered 150 mg of aspirin orally after an adequate meal as described in the Materials and Methods. Both the SBP and DBP as well as plasma dermcidin levels were measured at different times as indicated. Solid bars () represent the SBP, gray bars () represent the DBP and the patterned bars () indicate the dermcidin level. The SBP and DBP were measured in each individual at least for 3 times by a mercury sphygmomanometer and expressed in mean ± S.D. The plasma dermcidin levels were measured by ELISA in 3 different experiments, each in triplicate.
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Figure 1: The effect of oral administration of aspirin on the elevated blood pressures after different periods of time. Seventy four hypertensive patients (n=74; M=37, F=37) were administered 150 mg of aspirin orally after an adequate meal as described in the Materials and Methods. Both the SBP and DBP as well as plasma dermcidin levels were measured at different times as indicated. Solid bars () represent the SBP, gray bars () represent the DBP and the patterned bars () indicate the dermcidin level. The SBP and DBP were measured in each individual at least for 3 times by a mercury sphygmomanometer and expressed in mean ± S.D. The plasma dermcidin levels were measured by ELISA in 3 different experiments, each in triplicate.

Mentions: As hypertension in humans is considered to be an incurable disease and the condition is kept under control usually by the continuous use of antihypertensive compounds, studies were conducted to determine whether aspirin could be used on a continuing basis to control the elevated blood pressures. For this purpose, a group of subjects who were determined to have EH (n=74; M=37, F=37; between the ages of 30-60 yrs) were randomly selected from the participating subjects as described in the Materials and Methods. These subjects received 150 mg aspirin every 24 h. It was found that the SBP of these subjects which was 172.5 ± 1.6 mm (Mean ± S.D.) of Hg before the administration of aspirin was reduced to 138.2 ± 6.1 mm of Hg at 3 h after the ingestion of the compound. The DBP which was 99.5 ± 2.1 mm of Hg before the use of aspirin was found to be decreased to 81.5 ± 2.9 mm of Hg at the same time (i.e., at 3 h). The continuation of aspirin in these subjects resulted in the decrease of the SBP to 136.2 ± 4.2 mm of Hg at day 30 and to 135 ± 0.5 mm of Hg and 130.2 ± 5 mm of Hg at day 60 and 90 respectively. The DBP at day 30 was 81.7 ± 3.4 mm of Hg, 80.7 mm of Hg at day 60 and 80.5 ± 2.8 mm of Hg at day 90 respectively (Fig. 1). Simultaneously, a group of subjects who had high blood pressures, were not given any aspirin, were treated as control, there was no significant change in SBP (175.5 ± 2.1 mm of Hg), DBP (99 ± 1.9 mm of Hg) and dermcidin level (112.9 nM) during the experiment i.e. up to 90 days.


The Effect of Acetyl Salicylic Acid Induced Nitric Oxide Synthesis in the Normalization of Hypertension through the Stimulation of Renal Cortexin Synthesis and by the Inhibition of Dermcidin Isoform 2, A Hypertensive Protein Production.

Ghosh R, Bank S, Maji UK, Bhattacharya R, Guha S, Khan NN, Sinha AK - Int J Biomed Sci (2014)

The effect of oral administration of aspirin on the elevated blood pressures after different periods of time. Seventy four hypertensive patients (n=74; M=37, F=37) were administered 150 mg of aspirin orally after an adequate meal as described in the Materials and Methods. Both the SBP and DBP as well as plasma dermcidin levels were measured at different times as indicated. Solid bars () represent the SBP, gray bars () represent the DBP and the patterned bars () indicate the dermcidin level. The SBP and DBP were measured in each individual at least for 3 times by a mercury sphygmomanometer and expressed in mean ± S.D. The plasma dermcidin levels were measured by ELISA in 3 different experiments, each in triplicate.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4199471&req=5

Figure 1: The effect of oral administration of aspirin on the elevated blood pressures after different periods of time. Seventy four hypertensive patients (n=74; M=37, F=37) were administered 150 mg of aspirin orally after an adequate meal as described in the Materials and Methods. Both the SBP and DBP as well as plasma dermcidin levels were measured at different times as indicated. Solid bars () represent the SBP, gray bars () represent the DBP and the patterned bars () indicate the dermcidin level. The SBP and DBP were measured in each individual at least for 3 times by a mercury sphygmomanometer and expressed in mean ± S.D. The plasma dermcidin levels were measured by ELISA in 3 different experiments, each in triplicate.
Mentions: As hypertension in humans is considered to be an incurable disease and the condition is kept under control usually by the continuous use of antihypertensive compounds, studies were conducted to determine whether aspirin could be used on a continuing basis to control the elevated blood pressures. For this purpose, a group of subjects who were determined to have EH (n=74; M=37, F=37; between the ages of 30-60 yrs) were randomly selected from the participating subjects as described in the Materials and Methods. These subjects received 150 mg aspirin every 24 h. It was found that the SBP of these subjects which was 172.5 ± 1.6 mm (Mean ± S.D.) of Hg before the administration of aspirin was reduced to 138.2 ± 6.1 mm of Hg at 3 h after the ingestion of the compound. The DBP which was 99.5 ± 2.1 mm of Hg before the use of aspirin was found to be decreased to 81.5 ± 2.9 mm of Hg at the same time (i.e., at 3 h). The continuation of aspirin in these subjects resulted in the decrease of the SBP to 136.2 ± 4.2 mm of Hg at day 30 and to 135 ± 0.5 mm of Hg and 130.2 ± 5 mm of Hg at day 60 and 90 respectively. The DBP at day 30 was 81.7 ± 3.4 mm of Hg, 80.7 mm of Hg at day 60 and 80.5 ± 2.8 mm of Hg at day 90 respectively (Fig. 1). Simultaneously, a group of subjects who had high blood pressures, were not given any aspirin, were treated as control, there was no significant change in SBP (175.5 ± 2.1 mm of Hg), DBP (99 ± 1.9 mm of Hg) and dermcidin level (112.9 nM) during the experiment i.e. up to 90 days.

Bottom Line: The plasma cortexin level at day 0, 1, 30 and 90 were 0.5 pmol/ml, 155.5 pmol/ml, 160.2 pmol/ml, 190.5 pmol/ml respectively with increased NO synthesis (r=+0.994).In vitro studies demonstrated that the incubation of the goat kidney cortex cells with aspirin stimulated (r)-cortexin synthesis due to NO synthesis.It could be suggested that the use of aspirin might control EH in man.

View Article: PubMed Central - PubMed

Affiliation: Sinha Institute of Medical Science and Technology, Garia 700084, India;

ABSTRACT
Currently, there is no specific medication for essential hypertension (EH), a major form of the condition, in man. As acetyl salicylic acid (aspirin) is reported to stimulate the synthesis of renal (r)-cortexin, an anti-essential hypertensive protein, and, as aspirin is reported to inhibit dermcidin isoform 2 (dermcidin), a causative protein for EH, the role of aspirin in the control of EH in man was studied. Oral administration of 150 mg aspirin/70 kg body weight in subjects with EH was found to reduce both the elevated systolic and diastolic blood pressures to normal levels within 3 h due to the normalization of dermcidin level in these subjects. The plasma cortexin level at day 0, 1, 30 and 90 were 0.5 pmol/ml, 155.5 pmol/ml, 160.2 pmol/ml, 190.5 pmol/ml respectively with increased NO synthesis (r=+0.994). In vitro studies demonstrated that the incubation of the goat kidney cortex cells with aspirin stimulated (r)-cortexin synthesis due to NO synthesis. It could be suggested that the use of aspirin might control EH in man.

No MeSH data available.


Related in: MedlinePlus