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Initial puffing behaviors and subjective responses differ between an electronic nicotine delivery system and traditional cigarettes.

Norton KJ, June KM, O'Connor RJ - Tob Induc Dis (2014)

Bottom Line: Lab visits included measurement of exhaled carbon monoxide (CO) and salivary cotinine concentration, questionnaire measures of regular cigarette craving after the 72 hour abstinence, and subjective product effects.Cigarette craving scores dropped significantly after smoking regular cigarettes, but not ENDS (p = .001), and subjective measures showed ENDS rated less favorably.CO boost, after ENDS use, decreased significantly (p < .001), and saliva cotinine significantly dropped between visits 1 and 3 (p < 0.001) after ENDS use relative to after cigarette smoking.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Health Behavior, Roswell Park Cancer Institute, Elm and Carlton Streets, 14263 Buffalo, NY, USA.

ABSTRACT

Background: Electronic nicotine delivery systems (ENDS) present an emerging issue for tobacco control and data on product use behaviors are limited.

Methods: Participants (N = 38 enrolled; N = 16 compliant) completed three lab visits over 5 days and were asked to abstain from regular cigarettes for 72 hours in favor of ENDS (Smoke 51 TRIO - 3 piece, First Generation with 11 mg/ml filters). Lab visits included measurement of exhaled carbon monoxide (CO) and salivary cotinine concentration, questionnaire measures of regular cigarette craving after the 72 hour abstinence, and subjective product effects. Participants used a topography device to record puff volume, duration, flow rate, and inter-puff interval.

Results: Analyses revealed significant differences across products in puff count, average volume, total volume and inter-puff interval, with ENDS broadly showing a more intensive smoking pattern. Cigarette craving scores dropped significantly after smoking regular cigarettes, but not ENDS (p = .001), and subjective measures showed ENDS rated less favorably. CO boost, after ENDS use, decreased significantly (p < .001), and saliva cotinine significantly dropped between visits 1 and 3 (p < 0.001) after ENDS use relative to after cigarette smoking. For compliant and non-compliant participants, there was an average 82.0% [V1 - 16.1 cpd; V3 - 2.9 cpd] and average 73.9% [V1 - 20.3 cpd; V3 - 5.3 cpd] reduction in regular cigarette use per day during the ENDS trial period, respectively.

Conclusions: The ENDS were smoked more intensively than own brand cigarettes, but delivered significantly less nicotineand were less satisfying. These findings have implications for the viability of certain ENDS as alternatives to cigarettes.

No MeSH data available.


Flowchart of study participation.
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Related In: Results  -  Collection

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Figure 1: Flowchart of study participation.

Mentions: Figure 1 is a flowchart of the study from recruitment to final visit. Table 2 shows the demographic layout of the study participants. A total of 38 participants initiated the study with 21.1% (n = 8) being lost to follow-up. Even though 78.9% (n = 30) completed the study, only 42.1% (n = 16) of these 30 completers were actually compliant (CO ≤ 8 ppm) based on study guidelines.


Initial puffing behaviors and subjective responses differ between an electronic nicotine delivery system and traditional cigarettes.

Norton KJ, June KM, O'Connor RJ - Tob Induc Dis (2014)

Flowchart of study participation.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4199458&req=5

Figure 1: Flowchart of study participation.
Mentions: Figure 1 is a flowchart of the study from recruitment to final visit. Table 2 shows the demographic layout of the study participants. A total of 38 participants initiated the study with 21.1% (n = 8) being lost to follow-up. Even though 78.9% (n = 30) completed the study, only 42.1% (n = 16) of these 30 completers were actually compliant (CO ≤ 8 ppm) based on study guidelines.

Bottom Line: Lab visits included measurement of exhaled carbon monoxide (CO) and salivary cotinine concentration, questionnaire measures of regular cigarette craving after the 72 hour abstinence, and subjective product effects.Cigarette craving scores dropped significantly after smoking regular cigarettes, but not ENDS (p = .001), and subjective measures showed ENDS rated less favorably.CO boost, after ENDS use, decreased significantly (p < .001), and saliva cotinine significantly dropped between visits 1 and 3 (p < 0.001) after ENDS use relative to after cigarette smoking.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Health Behavior, Roswell Park Cancer Institute, Elm and Carlton Streets, 14263 Buffalo, NY, USA.

ABSTRACT

Background: Electronic nicotine delivery systems (ENDS) present an emerging issue for tobacco control and data on product use behaviors are limited.

Methods: Participants (N = 38 enrolled; N = 16 compliant) completed three lab visits over 5 days and were asked to abstain from regular cigarettes for 72 hours in favor of ENDS (Smoke 51 TRIO - 3 piece, First Generation with 11 mg/ml filters). Lab visits included measurement of exhaled carbon monoxide (CO) and salivary cotinine concentration, questionnaire measures of regular cigarette craving after the 72 hour abstinence, and subjective product effects. Participants used a topography device to record puff volume, duration, flow rate, and inter-puff interval.

Results: Analyses revealed significant differences across products in puff count, average volume, total volume and inter-puff interval, with ENDS broadly showing a more intensive smoking pattern. Cigarette craving scores dropped significantly after smoking regular cigarettes, but not ENDS (p = .001), and subjective measures showed ENDS rated less favorably. CO boost, after ENDS use, decreased significantly (p < .001), and saliva cotinine significantly dropped between visits 1 and 3 (p < 0.001) after ENDS use relative to after cigarette smoking. For compliant and non-compliant participants, there was an average 82.0% [V1 - 16.1 cpd; V3 - 2.9 cpd] and average 73.9% [V1 - 20.3 cpd; V3 - 5.3 cpd] reduction in regular cigarette use per day during the ENDS trial period, respectively.

Conclusions: The ENDS were smoked more intensively than own brand cigarettes, but delivered significantly less nicotineand were less satisfying. These findings have implications for the viability of certain ENDS as alternatives to cigarettes.

No MeSH data available.