Three-dimensional analysis of the early development of the dentition.
Bottom Line: The combination of in situ hybridization and 3D reconstruction have demonstrated the temporo-spatial dynamics of the signalling centres that reflect transient existence of rudimentary tooth primordia at loci where teeth were present in ancestors.The rudiments can rescue their suppressed development and revitalize, and then their subsequent autonomous development can give rise to oral pathologies.This shows that tooth-forming potential in mammals can be greater than that observed from their functional dentitions.
Affiliation: Department of Teratology, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Prague, Czech Republic.Show MeSH
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Mentions: According to embryological textbooks, the dental lamina is a U-shaped epithelial ridge in the embryonic upper or lower jaws arches; another U-shaped ridge, called vestibular lamina, runs in parallel and externally to the dental lamina (Fig. 9a). The vestibular lamina (the ‘lip-furrow band’ or ‘labio-gingival ridge’) is regarded as the origin of the oral vestibule, a free space between jaws bearing teeth on one side and the lips or cheeks on the other side.
Affiliation: Department of Teratology, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Prague, Czech Republic.